Part I Introduction; 1 Design of digital learning environments: Evidence from meta-analyses; Part II Learning with multimedia; 2 The effectiveness of learning with multimedia; 3 Design of effective digital reading comprehension environments; 4 GeoGebra, a comprehensive tool for learning mathematics; Part III Learning with digital videos; 5 Dynamic visualizations: How to overcome challenges and seize opportunities; 6 Six evidence-informed tips on how to optimize learning from instructional videos; 7 Eye movement modeling examples; Part IV Learning from simulated realities; 8 Learning with pedagogical agents in digital environments; 9 Designing effective immersive virtual reality learning environments; Part V Game-based and sensor-based learning in digital environments; 10 Effectiveness of gamification in education; 11 Sensors and wearables; Part VI Digital learning in social contexts; 12 Computer-supported collaborative learning; 13 Social media in class: Problem or panacea?; 14 Clicker for effective learning and instruction: An examination of the effects of audience response systems in the classroom; Part VII Designing digital classrooms; 15 Effectiveness of flipped classrooms; 16 Designing effective synchronous online learning; 17 Impacts of web-based inquiry learning environments aligned with knowledge integration pedagogy; Part VIII Discussion; 18 Increasing the effectiveness of digital learning; 19 Design of digital learning environments: Balancing theoretical, methodological, empirical, and technological approaches