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E-grāmata: Development of Science-based Guidelines for Laboratory Animal Care: Proceedings of the November 2003 International Workshop

  • Formāts: 262 pages
  • Izdošanas datums: 21-Oct-2004
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309545327
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  • Formāts: 262 pages
  • Izdošanas datums: 21-Oct-2004
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309545327
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The Development of Science-based Guidelines for Laboratory Animal Care is the summary of an international workshop held in Washington, DC, in November 2003 to bring together experts from around the world to discuss the available knowledge that can positively influence current and pending guidelines for laboratory animal care, identify gaps in that knowledge in order to encourage future research endeavors, and discuss the scientific evidence that can be used to assess the benefits and costs of various regulatory approaches affecting facilities, research, and animal welfare.

Table of Contents



Front Matter Introduction Plenary Lecture Session 1: Current Status: Identifying the Issues Session 2: Assessment of Animal Housing Needs in the Research Setting--Peer Reviewed Literature Approach Session 3: Approaches to Current Guidelines--US and Europe Session 4: Environmental Control for Animal Housing Dinner Speaker: Kay E. Holekamp Session 5: Environmental Enrichment Issues Point/Counterpoint: The Cases For and Against Harmonization Appendix A: International Workshop on Development of Science-based Guidelines for Laboratory Animal Care Appendix B: Workshop Faculty Appendix C: Committee Bios Appendix D: International Guiding Principles for Biomedical Research Involving Animals (1985)
Introduction 1(2)
Building the Case for Science-based Guidelines---Introductory Remarks
3(4)
Hilton J. Klein
PLENARY LECTURE
7(8)
Genes, Environments, and Mouse Behavior
9(6)
John C. Crabbe
SESSION 1: CURRENT STATUS: IDENTIFYING THE ISSUES
15(48)
AAALAC International Perspective
17(6)
John G. Miller
The Council of Europe: What Is It?
23(7)
Wim deLeeuw
ICLAS and the International Community
30(6)
Gilles Demers
Role of the National Institutes of Health Office of Laboratory Animal Welfare and the Public Health Service Policy on Humane Care and Use of Laboratory Animals
36(5)
Nelson L. Garnett
Regulatory Authority of the US Department of Agriculture Animal and Plant Health Inspection Service
41(5)
Chester A. Gipson
A Review and Comparison of Processes to Change Regulatory Guidelines: A European Perspective
46(4)
Jonathan Richmond
Japanese Regulations on Animal Experiments: Current Status and Perspectives
50(7)
Naoko Kagiyama
Tatsuji Nomura
Process for Change---Development and Implementation of Standards for Animal Care and Use in Canada
57(3)
Clement Gauthier
Building Credible Science from Quality, Animal-Based Information
60(3)
Paul Gilman
SESSION 2: ASSESSMENT OF ANIMAL HOUSING NEEDS IN THE RESEARCH SETTING---PEER-REVIEWED LITERATURE APPROACH
63(28)
Disruption of Laboratory Experiments Due to Leaching of Bisphenol A from Polycarbonate Cages and Bottles and Uncontrolled Variability in Components of Animal Feed
65(5)
Frederick S. vom Saal
Catherine A. Richter
Rachel R. Ruhlen
Susan C. Nagel
Wade V. Welshons
Assessment of Animal Housing Needs in the Research Setting Using a Peer-Reviewed Literature Approach: Dogs and Cats
70(9)
Graham Moore
Housing for Captive Nonhuman Primates: The Balancing Act
79(7)
Melinda Novak
Assessment of Animal Housing Standards for Rabbits in a Research Setting
86(5)
Markus Stauffacher
Vera Baumans
SESSION 3: APPROACHES TO CURRENT GUIDELINES---US AND EUROPE
91(40)
Housing Standards: Development of Guidelines and the Process for Change
93(7)
William J. White
Revision of Appendix A to the European Convention ETS 123: The Participants, the Process, and the Outcome
100(3)
Derek Forbes
Breakout Session: Rats and Mice
103(17)
Effects of Housing Density and Cage Type on Young Adult C57BL/6J Mice
107(7)
New Housing Standards for Rats and Mice Developed with Focus on the Needs of the Animals
114(6)
Breakout Session: Approaches for Implementing Current US and European Guidelines for Housing Standards for Dogs and Cats
120(1)
Breakout Session: Nonhuman Primates
121(7)
Breakout Session: Rabbit Housing
128(3)
SESSION 4: ENVIRONMENTAL CONTROL FOR ANIMAL HOUSING
131(36)
Environmental Controls (US Guidance)
133(7)
Bernard Blazewicz
Dan Frasier
European Guidelines for Environmental Control in Laboratory Animal Facilities
140(7)
Harry J. M. Blom
Breakout Session: Lighting
147(6)
Breakout Session: Effects of Sound on Research Animals
153(3)
Breakout Session: Environmental Control for Animal Housing---Impact on Metabolism and Immunology
156(8)
Breakout Session: Environmental Controls/Engineering Issues
164(3)
DINNER SPEAKER: KAY E. HOLEKAMP
167(8)
A View from the Field: What the Lives of Wild Animals Can Teach Us About Care of Laboratory Animals
169(6)
Kay E. Holekamp
SESSION 5: ENVIRONMENTAL ENRICHMENT ISSUES
175(24)
Enriching the Housing of the Laboratory Rodent: How Might It Affect Research Outcomes?
177(7)
William T. Greenough
Ann Benefiel
Search for Optimal Enrichment
184(5)
Timo Nevalainen
Breakout Session: Environmental Enrichment Issues: Mice/Rats/Rabbits
189(2)
Breakout Session: Environmental Enrichment for Dogs and Cats
191(2)
Breakout Session: Assessment of Nonhuman Primate Enrichment---Science Versus Welfare Concerns
193(6)
POINT/COUNTERPOINT: THE CASES FOR AND AGAINST HARMONIZATION
199(28)
Point/Counterpoint: The Cases For and Against Harmonization
201(26)
William S. Stokes
Appendix A: International Workshop on Development of Science-based Guidelines for Laboratory Animal Care 227(5)
Appendix B: Workshop Faculty 232(6)
Appendix C: Committee Bios 238(2)
Appendix D: International Guiding Principles for Biomedical Research Involving Animals (1985) 240
International Workshop on the Development of Science-based Guidelines for Laboratory Animal Care Program Committee, National Research Council