This book contains selected contributions of papers, many presented at the Second International Workshop on Neural Modeling of Brain Disorders, as well as a few additional papers on related topics, including a wide range of presentations describing computational models of neurological, neuropsychological and psychiatric disorders. It is a unique, comprehensive review of the state-of-the-art of modeling cognitive and brain disorders, appealing to a multidisciplinary audience of clinicians, psychologists, neuroscientists, cognitive scientists, computer scientists, and other neural network researchers.
The rest of the book is organized along four main themes, involving memory, neuropsychological, neurological and psychiatric disorders. In general, the cognitive disorders and these psychiatric diseases traditionally regarded as "functional" were modeled along functional lines, while those disorders traditionally viewed as "organic" neurological diseases generally drew more from knowledge of the underlying neurobiology and pathophysiology.
List of contributors v(4) Introduction ix(8) Acknowldgements xvii I. Memory disorders 3(72)
1. Neuromodulation and the hippocampus: memory function and dysfunction in a network simulation 3(16) M.E. Hasselmo (Boston, MA, USA)
2. Cholinergic neuromodulation and Alzheimers disease: from single cells to network simulations 19(28) E.D. Menschik L.H. Finkel (Philadelphia, PA, USA)
3. Episodic memory in semantic dementia: a computational approach based on the TraceLink model 47(20) K.S. Graham J.M.J. Murre J.R. Hodges (Cambridge, UK and Amsterdam, The Netherlands)
4. Multimodular networks and semantic memory impairments 67(8) D. Horn N. Levy E. Ruppin (Tel Aviv, Israel) II. Neuropsychology 75(128)
5. Understanding failures of learning: Hebbian learning, competition for representational space, and some preliminary experimental data 75(6) J.L. McClelland A.G. Thomas B.D. McCandliss J.A. Fiez (Pittsburgh, PA, USA)
6. Frames of reference in hemineglect: a computational approach 81(18) A. Pouget S. Deneve T.J. Sejnowski (Rochester, NY and La Jolla, CA, USA)
7. Explaining object-based deficits in unilateral neglect without object-based frames of reference 99(22) M.C. Mozer (Boulder, CO, USA)
8. Inter-hemispheric competition of sub-cortical structures is a crucial mechanism in paradoxical lesion effects and spatial neglect 121(22) C.-C. Hilgetag R. Kotter M.P. Young (Newcastle upon Tyne, UK and Dusseldorf, Germany)
9. A new model of letter string encoding: simulating right neglect dyslexia 143(22) C. Whitney R.S. Berndt (Baltimore, MD, USA)
10. Prosopagnosia in modular neural network models 165(20) M.N. Dailey G.W. Cottrell (La Jolla, CA, USA)
11. Functional brain imaging and modeling of brain disorders 185(18) M.-A. Tagamets B. Horwitz (Washington, DC and Bethesda, MD, USA) III. Neurology 203(108)
12. Unmasking unmasked: neural dynamics following stroke 203(16) W.W. Lytton S.T. Williams S.J. Sober (Madison, WI, USA)
13. Effects of callosal lesions in a computational model of single-word reading 219(24) J. Chhabra M. Glezer Y. Shkuro S.D. Gittens J.A. Reggia (College Park, MD, USA)
14. Penumbral tissue damage following acute stroke: a computational investigation 243(18) E. Ruppin K. Revett E. Ofer S. Goodall J.A. Reggia (Tel Aviv, Israel and College Park, MD, USA)
15. The gating functions of the basal ganglia in movement control 261(16) J.L. Contreras-Vidal (Tempe, AZ, USA)
16. Motor fluctuations in Parkinsons disease: a postsynaptic mechanism derived from a striatal model 277(12) R. Kotter (Dusseldorf, Germany)
17. Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges 289(22) A. Destexhe D.A. McCormick T.J. Sejnowski (Quebec Canada, New Haven, CT and La Jolla, CA, USA) IV. Psychiatry 311(122)
18. Using a speech perception neural network simulation to explore normal neurodevelopment and hallucinated voices in schizophrenia 311(16) R.E. Hoffman T.H. McGlashan (New Haven, CT, USA)
19. Dopamine, cognitive control, and schizophrenia: the gating model 327(24) T.S. Braver J.D. Cohen (St. Louis, MO, Princeton, NJ and Pittsburgh, PA, USA)
20. Modeling prefrontal cortex delay cells: the role of dopamine in schizophrenia 351(24) A. Reid D. Willshaw (Edinburgh, UK)
21. Neural models of normal and abnormal behavior: what do schizophrenia, Parkinsonism, attention deficit disorder, and depression have in common? 375(32) S. Grossberg (Boston, MA, USA)
22. A neural network model of attention biases in depression 407(26) G.J. Siegle (San Diego, CA, USA) Subject index 433
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