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DNA Liquid-Crystalline Dispersions and Nanoconstructions [Hardback]

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  • Formāts: Hardback, 304 pages, height x width: 234x156 mm, weight: 720 g, 13 Tables, black and white; 19 Illustrations, color; 128 Illustrations, black and white
  • Sērija : Liquid Crystals Book Series
  • Izdošanas datums: 02-Sep-2011
  • Izdevniecība: CRC Press Inc
  • ISBN-10: 1439871469
  • ISBN-13: 9781439871461
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DNA Liquid-Crystalline Dispersions and NanoconstructionsPalielināt
  • Formāts: Hardback, 304 pages, height x width: 234x156 mm, weight: 720 g, 13 Tables, black and white; 19 Illustrations, color; 128 Illustrations, black and white
  • Sērija : Liquid Crystals Book Series
  • Izdošanas datums: 02-Sep-2011
  • Izdevniecība: CRC Press Inc
  • ISBN-10: 1439871469
  • ISBN-13: 9781439871461
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9781439871461.html
Keywords:
The discovery of the spatial structure of the double-stranded DNA molecule is one of the greatest achievements of science. It would not be an exaggeration to say that the DNA double helix is a distinguished symbol of modern biology.

Divided into three parts, DNA Liquid-Crystalline Dispersions and Nanoconstructions covers the information presently available on the condensation of various forms of DNA and describes practical applications of the peculiar properties of the liquid-crystalline particles.





Part 1 describes the main methods used for condensation of linear high- and low-molecular mass DNA, including their complexes with polycations and circular DNA Part 2 compares the state and reactivity of double-stranded nucleic acid molecules fixed spatially in the liquid-crystalline as well as the same molecules under intracellular conditions Part 3 explains how the discovery of the fundamental principles underlying the formation of nucleic acid liquid-crystalline dispersion particles opens a gate for the operational use of these principles in the area of nanotechnology and biosensorics

With detailed coverage of DNA liquid crystals, this book provides an understanding of the information presently available on the condensation of various forms of DNA. Double-stranded nucleic acids, spatially organized in a liquid-crystalline structure, represent an important polyfunctional tool for molecular biology and nanobiotechnology. The possibility of programmed and controlled variations in the properties of these molecules and in the characteristics of their liquid-crystalline dispersions, provides wide options for the formation of biologically active three-dimensional structures with unique, widely applicable properties.
Authors' Preface xi
Editor's Preface xiii
Foreword xv
Introduction xvii
Outline xxxiii
SECTION I The Liquid-Crystalline State of the DNA
Chapter 1 The Condensed State of the High-Molecular-Mass Double-Stranded DNA
3(30)
1.1 The DNA Condensation and Aggregation
3(1)
1.2 Polyphosphates as a Simplified DNA Model
4(6)
1.3 Models of High-Molecular-Mass DNA Condensation in Water-Polymeric Solutions
10(10)
1.4 Grosberg Model of High-Molecular-Mass DNA Condensation
20(7)
1.5 Summary
27(6)
References
28(5)
Chapter 2 Liquid-Crystalline Phases of the Low-Molecular-Mass Double-Stranded DNA Molecules
33(10)
2.1 Ordering of Low-Molecular-Mass Double-Stranded DNAs
33(1)
2.2 Brief Concept of Types of Liquid-Crystalline Phases
34(2)
2.3 Liquid-Crystalline Phases of Low-Molecular-Mass Double-Stranded DNA Molecules
36(5)
2.4 Summary
41(2)
References
41(2)
Chapter 3 Dispersions of Low-Molecular-Mass Double-Stranded DNA Molecules
43(6)
3.1 Low-Molecular-Mass Double-Stranded DNA Dispersions in Water-Polymer Solutions
43(1)
3.2 Formation of DNA Dispersions in PEG-Containing Solutions
43(4)
3.3 Summary
47(2)
References
48(1)
Chapter 4 Circular Dichroism of Nucleic Acid Dispersions
49(36)
4.1 Circular Dichroism as a Method of Proof of Cholesteric Packing of Nucleic Acid Molecules in Dispersion Particles and Analysis of Their Properties
49(14)
4.2 Effect of Different Factors on Formation and Properties of CLCD Particles
63(15)
4.2.1 Factors Determining CLCD Particle's Structure at "Moment of Formation"
63(1)
4.2.1.1 DNA Molecule's Length
63(1)
4.2.1.2 Structure of Rigid, Double-Stranded, Nucleic Acid Molecules
64(1)
4.2.1.3 Osmotic Pressure of PEG-Containing Solutions
65(1)
4.2.1.4 Effect of Ionic Composition of the Solvent on DNA CLCD Formation
66(4)
4.2.1.5 Ionic Content of Solutions and Efficiency of DNA CLCD Formation
70(3)
4.2.1.6 Dielectric Constants of PEG Water-Salt Solution
73(1)
4.2.2 Factors Influencing Type of Nucleic Acid Molecules' Spatial Packing in CLCD Particles after Their Formation
74(1)
4.2.2.1 Role of Solution Temperature
74(3)
4.2.2.2 Change in Mode of Interaction between Adjacent DNA Molecules Fixed in Structure of CLCD Particles
77(1)
4.3 Order Parameter of Nucleic Acid Molecules in CLCD Particles
78(3)
4.4 Summary
81(4)
References
82(3)
Chapter 5 Polymorphism of Liquid-Crystalline Structures Formed by (DNA-Polycation) Complexes
85(30)
5.1 Some Peculiarities of Interaction of DNA Molecules with Polycations
85(5)
5.2 Specificity of Chitosan Binding to DNA
90(1)
5.3 Formation of Dispersions of (DNA-Chitosan) Complexes
91(1)
5.4 CD Spectra of Dispersions Formed by (DNA-Chitosan) Complexes
92(1)
5.5 X-Ray Parameters of Phases Formed by (DNA-Chitosan) Complexes
93(2)
5.6 Dependence of Efficiency of CLCD Formation by (DNA-Chitosan) Complexes on Various Factors
95(3)
5.7 Peculiarities of Interaction of Chitosan Molecules with Nucleic Acids
98(3)
5.8 Attempt at a Theoretical Description of Interactions Occurring in the (DNA-Chitosan) Complexes and Resulting in the Formation of Liquid-Crystalline Dispersions with Different Optical Properties
101(10)
5.9 Summary
111(4)
References
111(4)
Chapter 6 Liquid-Crystalline State of DNA Circular Molecules
115(26)
6.1 Phase Exclusion of Circular Molecules of Nucleic Acids
115(1)
6.2 Formation of Dispersions from Circular Superhelical DNA
116(2)
6.3 CD Spectra of Circular Superhelical DNA Dispersions under Conditions That Modify Parameters of Their Secondary Structure
118(6)
6.4 Packing Density and Rearrangement of the Spatial Structure of Superhelical DNA Molecules in LCD Particles
124(2)
6.5 Topological Forms and Rearrangement of the Spatial Organization of Superhelical DNA Molecules in LCD Particles
126(8)
6.6 Summary
134(7)
References
134(2)
Section I Summary
136(5)
SECTION II DNA LIQUID-CRYSTALLINE FORMS AND THEIR BIOLOGICAL ACTIVITY
Chapter 7 Liquid-Crystalline State of DNA in Biological Objects
141(8)
7.1 DNA and Biological Objects
141(7)
7.2 Summary
148(1)
References
148(1)
Chapter 8 DNA Reactions under Conditions Causing Liquid-Crystalline Dispersions
149(22)
8.1 Molecular Crowding
149(1)
8.2 Condensation of DNA under the Effect of Chitosan in Conditions Causing Molecular Crowding
150(4)
8.3 Activity of Nucleolytic Enzymes under Conditions of Molecular Crowding
154(3)
8.3.1 Effect of Nucleases on Superhelical DNA-Forming LCD Particles
154(1)
8.3.2 Specificity of Nuclease Action under Conditions of Molecular Crowding
154(3)
8.4 Activity of Proteolytic Enzymes under Conditions of Molecular Crowding
157(4)
8.5 Other Biochemical Processes under Conditions of Molecular Crowding
161(4)
8.6 Summary
165(6)
References
165(2)
Section II Summary
167(4)
SECTION III DNA LIQUID-CRYSTALLINE DISPERSIONS IN NANOTECHNOLOGY AND BIOSENSORICS
Chapter 9 Nanoconstructions Based on Nucleic Acid Molecules
171(44)
9.1 The General Concept of Nanotechnology
171(12)
9.2 Biological Molecules as a Background for Nanodesign
183(2)
9.3 Two Strategies of Nanodesign Based on NA Molecules
185(25)
9.3.1 Nanoconstructions Created by Modification of Linear NA Molecule Structure
185(8)
9.3.2 Theoretical Approaches to the Problem of Guest Accumulation in Nanoconstructions Based on Nucleic Acid Molecules
193(4)
9.3.3 Nanoconstructions Based on NA Molecules Ordered by Entropy Condensation
197(8)
9.3.4 Nanoconstructions Based on NA Molecules Ordered as a Result of Enthalpy Condensation
205(5)
9.4 Summary
210(5)
References
210(5)
Chapter 10 Biosensors Based on Nucleic Acids
215(36)
10.1 General Concept of Construction and Operation of Biosensors
215(5)
10.2 Double-Stranded DNA Molecule as Polyfunctional Biosensing Unit
220(2)
10.3 Content and Principle of Operation of an Optical Biosensor Based on DNA Liquid-Crystalline Dispersions
222(2)
10.4 DNA CLCD Particles as Sensing Units
224(10)
10.4.1 Detection of BAC Causing Distortion of Double-Stranded DNA Structure (First Approach)
225(2)
10.4.2 Detection of Colored BAC ("External Chromophores") Intercalating between DNA Nitrogen Base Pairs in CLCD Particles (The Second Approach)
227(4)
10.4.3 Synthetic Polymer Matrixes Containing DNA CLCD as Film-Type Biosensing Units
231(3)
10.5 Sandwich-Type Biosensing Units Based on (DNA-Polycation) Liquid-Crystalline Dispersions
234(4)
10.6 DNA Nanoconstruction as a Sensing Unit (New Type of Biodetectors)
238(4)
10.7 Hydrogels Containing DNA NaCs as New "Film-Type" Biodetectors
242(3)
10.8 Summary
245(6)
References
245(3)
Section III Summary
248(3)
Index 251
Yevdokimov Yuri Mikhailovich - Dr. Sci. (Chemistry), Professor: Head of the Condensed State of Nucleic Acids laboratory at Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences. Interests: chemistry of natural and physiologically relevant compounds (especially, nucleic acids), lyotropic liquid crystals of biopolymers, biosensors, and nanotechnology of nucleic acids.

Salyanov Victor Ivanovich - Ph.D. (Chemistry): Senior research scientist of the Condensed State of Nucleic Acids laboratory at Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences. Interests: chemistry of natural and physiologically relevant compounds, lyotropic liquid crystals of nucleic acids, and nanotechnology of nucleic acids.

Semenov Sergey Victorovich - Ph.D. (Physics): Senior research scientist at the Russian Research Centers Kurchatov Institute Interests: physics of liquid crystals, elementary particles physics and interaction of radiation with matter

Skuridin Sergey Gennadievich - Dr. Sci. (Molecular Biology): Leading research scientist of the Condensed State of Nucleic Acids laboratory at Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences. Interests: biochemistry of natural and physiologically relevant compounds, lyotropic liquid crystals of nucleic acids, biosensors, and nanotechnology of nucleic acids.