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E-grāmata: DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression

Edited by (Department of Neurobiology and Behavior, University of California, Irvine, USA)
  • Formāts: PDF+DRM
  • Izdošanas datums: 23-Dec-2016
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780128017814
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DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene ExpressionPalielināt
  • Formāts: PDF+DRM
  • Izdošanas datums: 23-Dec-2016
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780128017814
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DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states.

Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.

  • Provides a comprehensive overview of the many facets of DNA modifications
  • Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels
  • Contains contributions by influential leaders in the field
  • Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance

Papildus informācija

A comprehensive reference on the role of the epigenome in gene expression and brain function in both normal and diseased states
List of Contributors to Preface
xi
1 History and Modern View on DNA Modifications in the Brain
1(26)
B.F. Vanyushin
V.V. Ashapkin
Introduction
1(3)
DNA Methylation and Its Influence on DNA Structure and Interaction With Proteins
4(1)
Replicative DNA Methylation and the Inheritance of the DNA Methylation Pattern
5(1)
DNA Methyltransferases
5(2)
DNA Demethylation
7(2)
Specificity of DNA Methylation
9(2)
Functional Roles of DNA Methylation
11(9)
Conclusion
20(1)
Acknowledgment
20(1)
References
20(7)
2 Approaches to Detecting DNA Base Modification in the Brain
27(16)
X. Li
W. Wei
Methods for Detection of DNA Modifications in the Genome
27(1)
Bisulfite Sequencing for the Detection of 5mC
28(1)
Analysis of Bisulfite-Treated DNA Without Sequencing
29(1)
Extending Bisulfite Sequencing: Beyond 5mC
30(1)
Restriction Enzymes for DNA Modifications
31(1)
DNA Immunoprecipitation
32(1)
Other Chemical Approaches
33(1)
Summary
34(1)
Detection of DNA Modifications in the Brain
34(1)
Candidate Gene Approach
34(1)
Microarray Screening
35(1)
Genome-Wide Sequencing Approaches
36(1)
Conclusions and Future Directions
37(1)
References
37(6)
3 Active DNA Demethylation in Neurodevelopment
43(18)
Y. Kang
Z. Wang
P. Jin
Introduction
43(1)
Fundamental Brain Development
43(2)
Interplay of DNA Methylation and Demethylation
45(5)
Mapping and Quantification of the Derivatives of 5mC
50(2)
Discussion
52(2)
References
54(7)
4 TET and 5hmC in Neurodevelopment and the Adult Brain
61(20)
M. Fasolino
S.A. Welsh
Z. Zhou
Introduction
61(1)
Global 5hmC and Tet Expression Throughout the Adult Brain
62(2)
Genomic Distribution of 5hmC
64(3)
Role of 5hmC in Brain Development
67(1)
5hmC Changes Associated With Neuronal Differentiation
68(1)
Role of 5hmC in Aging and Neurodegeneration
69(1)
Role of Tet Enzymes in Brain Function
69(2)
Tet1
71(3)
Tet2
74(1)
Tet3
74(2)
Conclusion
76(1)
References
77(4)
5 Beyond mCG: DNA Methylation in Noncanonical Sequence Context
81(14)
E.A. Mukamel
R. Lister
Introduction: Beyond CG Methylation
81(2)
Variable Non--CG Methylation Across Cell Types
83(2)
Non--CG Methylation and Brain Cell Diversity
85(2)
Non--CG Methylation in X Chromosome Inactivation
87(1)
Possible Functions of Non--CG Methylation
87(2)
Outlook and Future Directions
89(2)
Acknowledgments
91(1)
References
91(4)
6 DNA Modifications and Memory
95(18)
J.J. Day
Introduction
95(1)
DNA Modifications and Neuronal Memory
96(1)
DNA Modification and Behavioral Memory
97(5)
Future Directions
102(2)
Conclusions
104(2)
Acknowledgments
106(1)
References
106(7)
7 Measuring CpG Methylation by SMRT Sequencing
113(14)
Y. Suzuki
J. Korlach
S. Morishita
DNA Methylome of Disease-Associated Repeats
113(1)
Traditional Methods for Observing DNA Methylome
113(1)
SMRT Sequencing to Detect DNA Modifications
114(2)
Prediction of the Regional Methylation State From Kinetic Data
116(2)
Genome-Wide Methylation Pattern of Repetitive Elements in the Human Genome
118(2)
Analysis of an Active Transposable Element
120(1)
Discussion
121(2)
References
123(4)
8 Epigenetic Modifications of DNA and Drug Addiction
127(22)
J. Feng
E. J. Nestler
Introduction
127(1)
Addiction and Reward Pathway
128(1)
DNA Methylation and Its Catalyzing DNMT Enzymes in Addiction
129(7)
Methyl-Cytosine Oxidation and Its TET Catalyzing Enzymes in Addiction
136(1)
Genome-Wide Mapping of DNA Modifications in Addiction
137(2)
Challenges and Future Directions
139(2)
Acknowledgments
141(1)
References
141(8)
9 What Does the Future Hold for the Study of Nucleic Acid Modifications in the Brain?
149(12)
P.R. Marshall
T.W. Bredy
Expanding the Realm of Possibility: DNA Modifications on All Four Bases
150(1)
DNA Modifications Drive DNA Structure and Function
151(1)
DNA Modifications Influence DNA Editing
152(1)
Taking Neuroepigenetics to the Next Level: Epitranscriptomics Comes of Age
153(1)
Outstanding Questions and Emerging Technologies
154(2)
Summary and Conclusions
156(1)
References
156(5)
Index 161
Dr. Timothy Bredy is Associate Professor of Neuroscience in the Ayala School of Biological Sciences at the University of California Irvine and Senior Research Fellow within the Queensland Brain Institute at the University of Queensland.
Biežāk uzdotie jautājumi par e-grāmatām Biežāk uzdotie jautājumi par e-grāmatām
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