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E-grāmata: DNA Replication - Damage from Environmental Carcinogens

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DNA Replication - Damage from Environmental CarcinogensPalielināt
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This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.

Recenzijas

It is focused on how environmental carcinogens affect DNA replication because it is well-known that correct DNA replication is the first crucial factor for the integrity of genetic informa­tion. The book is an interesting and enriching contribution which can help to understand the impact of environmental carcinogens on living organism. (Darina Slamenova, Neoplasma, Vol. 63 (2), 2016)

1 DNA Replication
1(4)
1.1 The Mechanism of DNA Replication
1(2)
1.2 Classification and Structure of DNA Polymerases
3(2)
Further Reading
3(2)
2 Disturbances of the DNA Replication System
5(10)
2.1 DNA Damage Blocks DNA Replication
5(2)
2.2 DNA Damage Increases Misincorporation Ratio
7(1)
2.3 DNA Damage Forms Frameshift During DNA Replication
8(2)
2.4 DNA--DNA Cross-Linking Destroys DNA Replication
10(5)
Further Reading
11(4)
3 Fate of DNA Replisome upon Encountering DNA Damage
15(6)
3.1 The DNA Replisome of E. coli, T7 and T4
15(1)
3.2 The E. coli DNA Replisome Bypassing DNA Damage
16(1)
3.3 The T4 DNA Replisome Bypassing DNA Damage
17(1)
3.4 The T7 DNA Replisome Bypassing DNA Damage
18(3)
Further Reading
18(3)
4 External Causes for DNA Damage
21(6)
4.1 Environmental Carcinogens
21(1)
4.2 Formation of DNA Damage After Exposure to Environmental Carcinogens
21(3)
4.3 Disease, Cancer, and Tumor Resulted from Environmental Carcinogens
24(3)
Further Reading
24(3)
5 Effect of Environmental Carcinogens on Cellular Physiology
27(8)
5.1 Overview of Biological Activities of Cells
27(1)
5.2 Cell Cycle
28(1)
5.3 Cell Proliferation and Apoptosis
29(6)
5.3.1 Cell Apoptosis
29(1)
5.3.2 Cell Proliferation
29(2)
5.3.3 Gene Expression
31(1)
5.3.4 Cell and Tissue
32(1)
Further Reading
32(3)
6 Protocols for Studies of Bypass of DNA Damage by DNA Polymerase
35
6.1 Introduction
35(1)
6.2 Kinetic Analysis of Bypass of DNA Damage
36(4)
6.2.1 Materials
36(1)
6.2.2 Preparation of Reaction Buffer
36(1)
6.2.3 Preparation of Reaction Quench Buffer
36(1)
6.2.4 Preparation of Primer/Template that Contains DNA Damage at Incorporation Position
36(1)
6.2.5 Analysis of DNA Incorporation Product
36(1)
6.2.6 Primer Extension Assay with All Four dNTPs
37(1)
6.2.7 Steady-State Kinetic Analyses
37(1)
6.2.8 Pre-steady-state Reactions
37(1)
6.2.9 Pre-steady-state Trap Experiments
38(1)
6.2.10 Phosphorothioate Analysis
38(1)
6.2.11 Stopped-Flow Fluorescence Measurements of Conformational Change
38(1)
6.2.12 Kinetic Simulations
39(1)
6.3 LC-MS/MS Sequence Analysis of Extension Products Beyond DNA Damage
40(1)
6.3.1 Materials
40(1)
6.3.2 Preparation Sample of DNA Extension Products Beyond DNA Damage
40(1)
6.3.3 LC-MS/MS Sequence Analysis of Extension Products
40(1)
6.4 X-Ray Crystal Structure Analysis of DNA Polymerase with DNA Containing DNA Damage
41
6.4.1 Materials
41(1)
6.4.2 Crystallization of Polymerase with DNA Containing DNA Damage
41(1)
6.4.3 X-ray Diffraction Data Collection and Processing
42(1)
6.4.4 Structure Determination and Refinement
42(1)
Further Reading
42
Dr. Huidong Zhang is a professor and assistant director of the Institute of Toxicology, Preventive Medical College, Third Military Medical University in China, and the winner of Chinas Thousand Youth Talents Plan. His research focuses on DNA damage and replication, and he has published more than 20 original research articles in international peer-reviewed journals such as the PNAS, JBC and Cell Cycle.
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