Comprehensively reviews database establishment, computational tools, experimental strategies, and biochemistry/crystallographic studies of metalloenzymes and their drug discovery applications.
Metalloenzyme Informatics and Drug DesignMetal-Binding Pharmacophores in Metalloenzyme Drug DiscoveryModelling Metalloenzyme Catalytic Mechanisms by QM/MM CalculationsExperimental Strategies in Metalloenzyme Mechanism Study and Drug DiscoveryTargeting Metalloenzymes by Metallo-DrugsTargeting Metallo-ß-Lactamases to Combat Antibiotic ResistanceTargeting Disease-Linked Metalloenzymes Involved in RNA metabolismCyclic Nucleotide Phosphodiesterases: Important Therapeutic TargetsHDAC, A Rising Star in Cancer TherapyDrug Discovery Targeting Viral MetalloenzymesDrug Discovery Targeting Carbonic AnhydrasesTargeting Autotaxin for Therapeutic InterventionTargeting ENPP1 for Therapeutic InterventionDrug Discovery Targeting Oxygen-Sensing Hypoxia-Inducible Factor Prolyl HydroxylasesHijacking Histone Demethylase KDM5B for Novel TherapeuticsAdvances and Future Directions in Small-Molecule LpxC Inhibitors Targeting Gram-Negative Bacteria
Substrate and Inhibitor Discovery of Human Glutaminyl CyclasesDrug Discovery Targeting Tryptophan/Indoleamine 2,3-Dioxygenase
Guo-Bo Li is Professor in the Department of Medicinal Chemistry at Sichuan University, China. His research group now focuses on development of new computational tools, new data resources and new web servers to assist basic science and drug discovery research particularly targeting metalloenzymes, and development of new chemical probes, new hits/leads or drug candidates to exploit metalloenzyme biological/pathological roles and therapeutical potentials.
