"In the multi-disciplinary area of drug discovery/design, a strong background in chemistry was always deemed an asset. However, some paradigm shifts have taken place in basic and essential biochemistry. The distinction between enzymes and non-catalytic proteins is blurring; disorder is equally important as structure in dictating protein function. Drug promiscuity and protein promiscuity have been identified as the basis of drug repurposing. This book aims at being a stand-alone volume to capture these paradigm shifts. Apart from discussing current applications, the book will empower readers to explore possibilities where drug repurposing may offer a way out. This is vital for affordable drugs for orphan diseases; the pharma industry is not enthusiastic in investing efforts due to the small market size"-- Provided by publisher.
This volume is aimed at explaining how drug repurposing works; to what extent the initial hopes have been realised in finding drugs for neurodegenerative diseases, psychiatric disorders and diseases caused by parasitic worms. Multi-drug resistance has emerged as a great challenge in the drug development area.
This volume is aimed at explaining how drug repurposing works; to what extent the initial hopes have been realised in finding drugs for neurodegenerative diseases, psychiatric disorders, cancer and diseases caused by parasitic worms. Drug repurposing also has had some success in treating bacterial infections. Multi-drug resistance has emerged as a great challenge in the drug development area. Drug repurposing may help there as well; this has been discussed in the context of TB. Like in many other areas, nano-materials have been helpful in formulating drugs for repurposing.
The first chapter points out that [ a] drug repurposing heralds the demise of the magic bullet concept of drug actions [ b] both partners in a drug-target pair are promiscuous and drug repurposing is a subset of polypharmacology.
The last chapter talks of vaccine repurposing. Considerable data now exist which makes a compelling case for including this exciting topic.
This book is a fair mix of success stories, a reality check on the status of this approach and challenges ahead in this area.
Preface.
1. Polypharmacology: Drug Promiscuity Enabled by Protein
Promiscuity.
2. Approaches to Identify and Repurpose Drugs for
Neurodegenerative Diseases.
3. Drug Repurposing for Psychiatric Diseases.
4.
Drug Repurposing as a Novel Approach to Cancer Treatment.
5. Anticancer Drugs
for Repurposing Against Gram-Negative and Gram-Positive Bacterial Infections.
6. Repurposing Drugs for Effective Treatment of Tuberculosis: A Promising
Approach.
7. Repurposing Drugs as Anthelmintics: Expanding the Therapeutic
Arsenal Against Parasitic Worm Infections.
8. Applications of Nanomaterials
for Drug Repurposing.
9. A Review of the Use of Existing Vaccines as a First
Line of Defense in the SARS-CoV-2 Pandemic. Index.
Munishwar Nath Gupta taught chemistry, biochemistry and biotechnology at IIT Delhi [ 1975-2018]. A PhD in biochemistry from IISc Bangalore was followed by post-docs at University of Minnesota, USA; MIT, USA; UTC, France and Lund University, Sweden. He is a fellow of NASI, Allahabad and INSA, New Delhi. He has published over 300 scientific articles and edited 7 books so far. His current h-index is 63.
