This Open Access new edition of the EBMT handbook with its new format, addresses the latest developments and innovations in hematopoietic cell transplantation and cellular therapy. Consisting of 94 chapters, it has been written by 210 leading experts in the field.
Discussing all types of hematopoietic cell transplantation, including selection of stem cell sources, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies and new infections (COVID-19).
This book provides an unparalleled description of current practices to enhance readers knowledge and practice skills.
Part I . Introduction.-
1. HCT: Historical Perspective.-
2. The EBMT:
History, Present, and Future.-
3. Registries a bridge between donor and
recipient.-
4. The HCT Unit.-
5. JACIE Accreditation of HCT Programs.-
6.
Statistical Methods in HCT and Cellular Therapies.- Part II . Biological
Aspects.-
7. Biological Properties Of Hematopoietic Stem Cells: Scientific
Basis For Hematopoietic Cell Transplantation.-
8. Biological Properties of
Cells Other Than HSCs.-
9. Histocompatibility.-
10. Clinical and biological
concepts for mastering immune reconstitution after hematopoietic cell
transplantation: towards practical guidelines and greater harmonization.-
Part III . Methodology and Clinical Aspects.-
11. Evaluation and Counseling
of Candidates.-
12. Donor Selection for Adults and Pediatrics.-
13.
Conditioning.-
14. Selection of stem cell source.-
15. Bone Marrow Harvesting
for HCT.-
16. Mobilization and Collection of HSC.-
17. Mobilization and
Collection of HSC in Children.-
18. Procurement and Management of Cord Blood
Unit for allogeneic transplantation.-
19. Graft Manipulation.-
20.
Processing, Cryopreserving and Controlling the Quality of HSC.-
21.
Documentation of Engraftment and Chimerism After HCT.-
22. Short- and
Long-Term Controls After HCT.- Part IV . General Management of the Patient.-
23. Vascular Access.-
24. Transfusion Support.-
25. Nutritional Support.-
26.
GVHD Prophylaxis.-
27. Infection Control and Isolation Procedures.-
28.
General Management of the Patient: Specific Aspects of Infectious Disease
Supportive Care in Children.-
29. Vaccinations.-
30. Psychological Morbidity
and Care.-
31. Clinically Relevant Drug Interactions in HCT.-
32. The Roles
of the HCT Nurse.-
33. Ethical Issues in HCT.-
34. Quality of Life Assessment
After HCT for Pediatric and Adults.- Part V. HCT Complications and
Management.-
35. Neutropenic Fever.-
36. Bacterial Infections.-
37. Invasive
fungal diseases.-
38. Viral Infections.-
39. Other Life-Threatening
Infections.-
40. Bleeding and Thrombotic Complications.-
41. Graft Failure.-
42. Early complications of endothelial origin.-
43. Acute Graft-Versus-Host
Disease.-
44. Chronic Graft-Versus-Host Disease.-
45. Post-transplant
lymphoproliferative syndromes.-
46. Iron Overload.-
47. Secondary Neoplasia
(Other than PTLPS).- Part VI . Specific Organ Complications.-
48. Ocular and
Oral Complications .-
49. Hepatic complications.-
50. Gastrointestinal
Complications.-
51. Haemorrhagic Cystitis and Renal Dysfunction.-
52.
Noninfectious Pulmonary Complications.-
53. Neurological Complications.-
54.
Skin, Hair and Musculoskeletal Complications.-
55. Cardiovascular Diseases
and Metabolic Syndrome.-
56. Endocrine Disorders, Fertility and Sexual
Health.- Part VII . Prevention and Management of Relapse.-
57. Monitoring
Measurable Residual Disease in ALL and AML.-
58. Prevention and Treatment of
Relapse by Drugs.-
59. Delayed transfer of immune cells, or the art of donor
lymphocyte infusion (DLI) 2.0.-
60. Cellular Therapy with Engineered T Cells,
Efficacy and Side Effects: Gene Editing/Gene Therapy.-
61. Mechanisms of
Immune Resistance.-
62. Regulatory Aspects Of Atmp Versus Minimally
Manipulated Immune Cells.- Part VIII . Specific Modalities of HCT and
Management.-
63. At Home HCT.-
64. Role Of Umbilical Cord Blood
Transplantation.-
65. Haploidentical HCT.-
66. Photopheresis in Adults and
Pediatrics.-
67. Overweight and obese patients.-
68. HCT in Elderly
Patients.-
69. Feasibility and Experiences of HCT in Resource-constrained
Settings.- Part IX . Indications and Results.-
70. AML in adults.-
71. Acute
Myeloid Leukemia in Children.-
72. Acute Lymphoblastic Leukemia in Adults.-
73. Acute Lymphoblastic Leukemia in Children and Adolescents.-
74.
Myelodysplastic Neoplasms/Syndromes (MDS).-
75. Allogeneic hematopoietic cell
transplantation in pediatric MDS including refractory cytopenia of childhood
and in juvenile myelomonocytic leukemia .-
76.
Myelodysplastic/Myeloproliferative Neoplasms.-
77. Myeloproliferative
Neoplasms.-
78. Acquired bone marrow failure: Severe Aplastic Anemia and
Paroxysmal nocturnal hemoglobinuria.-
79. Fanconi Anemia and Other Hereditary
Bone Marrow Failure Syndromes.-
80. Hemoglobinopathies (Sickle Cell Disease
and Thalassemia).-
81. Multiple Myeloma.-
82. Systemic Light Chain
Amyloidosis.-
83. Poems Syndrome And Disease Produced By Other Monoclonal
IGS.-
84. Indolent Lymphoma.-
85. CHRONIC LYMPHOCYTIC LEUKEMIA.-
86. Large
B-Cell Lymphoma.-
87. Mantle Cell Lymphoma.-
88. Other B- and T-Aggressive
Lymphomas & Lymphomas Associated with HIV.-
89. Classical Hodgkins
Lymphoma.-
90. Inborn errors of immunity.-
91. Inborn Errors of Metabolism
and Osteopetrosis.-
92. Autoimmune Disease.-
93. CART cells & other cell
therapies (ie MSC, Tregs) in autoimmune diseases.-
94. Solid Tumours.
Anna Sureda, MD, PhD, is the EBMT President, Head of the Clinical Hematology Department and Hematopoietic Stem Cell Transplant Programme at Institut Catalą d'Oncologia - Hospital Duran i Reynals, Barcelona, Spain and Associate Professor of the University of Barcelona.
Selim Corbacioglu is the former Pediatric Diseases Working Party (PDWP) Chair and EBMT Scientific Council Chair, Professor and Chair of the Department of Hematology, Oncology and Stem Cell Transplantation at the Childrens Hospital in Regensburg, Germany.
Raffaella Greco, MD, is the current Autoimmune Diseases Working Party (ADWP) Chair and EBMT Scientific Council Representative with the Education Portfolio, and Senior Physician in the Blood and Marrow Transplant (BMT) Unit of the IRCCS San Raffaele Hospital in Milano, Italy
Nicolaus Kröger, MD, PhD, is the former EBMT President, Professor of Medicine and Medical Director of the Department of Stem Cell Transplantation at the University Medical Center Hamburg-Eppendorf, Germany.
Enric Carreras, MD, PhD, Medical Advisor of the Josep Carreras Foundation in Barcelona, Spain. EBMT Honorary member.
