A compilation of manuscripts from the first workshop on the Immunomodulation of Motility held in Montecito, California, March 1990. Papers are given by investigators currently working on aspects of smooth muscle and enteric nerve function, who contribute their evaluation of the potential impact of immunological or inflammatory processes. The field is in its infancy, but interaction between immunological/inflammatory processes and the motor apparatus of the gut are relevant to a wide range of disorders that range from peptic esophagitis to inflammatory bowel disease and are important to understanding of food allergy, graft vs. host diseases, certain types of pseudoobstruction, as well as many of the infectious gastroenteritidies and colitidies. Annotation copyright Book News, Inc. Portland, Or.
This book provides the first comprehensive review of research that addresses the immunomodulation of gastrointestinal motility. Results from this new field of research are important for understanding motility disturbances and symptom-generation in a variety of clinical gastroenterological problems, including ulcerative colitis, Crohn's disease, enteric infections, and food allergies. The book provides overviews on current perspectives regarding the nature of inflammatory processes, inflammatory mediators, and other immune factors. It also describes a variety of experimental approaches that have been used to study the interactions between immune cells and smooth muscle or enteric nerves. The approaches include in vivo, as well as in vitro studies. Researchers involved in the general field of immunophysiology, as well as the more specific fields of gastrointestinal motility and inflammatory bowel diseases will find this book to be invaluable in their research.
Preface (Stephen M. Collins, William J. Snape, Jr.). Acute and Chronic
Inflammation (Jack Gauldie). Healing and Repair (Robert Riddell). Cholesterol
Feeding and Gallbladder Muscle Contractility (Norman Weisbrodt, Young Fang
Li, Frank G. Moody, Diane Haley-Russell, Stuart I. Myers). Inflammation
Alters Smooth Muscle Function in the Gut: Studies on the Nematode-Infected
Rat (Stephen M. Collins, D.L. Vermillion, J.D. Huizinga, M.J. Muller).
Specific Effect of Infection and Malnutrition on Intestinal Longitudinal
Smooth Muscle Response in Yersinia Enterocolitica in the Rabbit (Brent
Scott). In-Vivo Colonic Motility and Transit in Ulcerative Colitis (S.
Narasimha Reddy, Gabriele Bazzocchi, Simon Chan, Kathy Akashi, Javier
Villanueva-Meyer, George Yanni, Ismael Mena, William J. Snape, Jr.). Effect
of Mucosal Inflammation on Colonic Smooth Muscle Contraction. (Y.N. Xie, W.
Gerthoffer, S.N. Reddy, V.E. Eysselein, F. Cominelli, W.J. Snape, Jr.). In
Vivo Motor Response to Gut Inflammation (Sushil K. Sarna, Mary F. Otterson,
Verne E. Cowles, Ashwani K. Sethi, Gordon L. Telford). An Investigation In
Vitro of the Properties of the Individual Muscle Layers of the Rabbit Colon
in an Induced Colitis (W.H. Percy, M.B. Burton, Y. Jacobowitx, R. Burakoff).
Smooth Muscle Function in Inflammatory Bowel Disease (Jan D. Huizinga, Dianne
L. Vermillion, Carla Cuthbert, Stephen M. Collins). Collagen Production by
the Intestinal Smooth Muscle Cell in Response to Inflammation: Wound Healing
in the Gut (Martin P. Graham). Smooth Muscle Growth in the Inflamed Intestine
of the Rat (M.G. Blennerhassett, S.M. Collins). Ultrastructure of Human
Gastrointestinal System. Interactions Among Mast Cells, Eosinophils, Nerves
and Muscle in Human Disease (Ann M. Dvorak). Gut Neuropeptides and the
Pathophysiology of Inflammatory Bowel Diseases (Timothy R. Koch, Ammon
Sonnenberg, J. Aidan Carney). Immunomodulation of Electrical and Synaptic
Behavior of Myenteric Neurons of Guinea Pig Small Intestine During Inf
Snape\, Jr.\, William J.; Collins\, Stephen M.
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