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E-grāmata: Emerging Horizons in Neuromodulation: New Frontiers in Brain and Spine Stimulation

Volume editor (Sunnybrook Research Institute, Toronto, Canada), Volume editor (University Hospital Center of Grenoble, France)
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This issue of International Review of Neurobiology brings together cutting-edge research on neuromodulation. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery.

This issue of International Review of Neurobiology brings together cutting-edge research on neuromodulation. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery.

Papildus informācija

This issue of International Review of Neurobiology brings together cutting-edge research on neuromodulation. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery
Contributors xi
1 Neuromodulation: A More Comprehensive Concept Beyond Deep Brain Stimulation
1(4)
Clement Hamani
Elena Moro
1 Introduction
1(4)
2 Computational Models of Neuromodulation
5(18)
Christopher R. Butson
1 Introduction
5(2)
2 Foundations of Neurostimulation Modeling
7(2)
3 Stimulation Safety
9(1)
4 Spinal Cord Stimulation for Pain
9(3)
5 Deep Brain Stimulation for Parkinson's Disease
12(5)
6 Limitations of Computational Models
17(1)
7 Conclusions
17(6)
Acknowledgments & Disclosures
18(1)
References
18(5)
3 Neurophysiology of Deep Brain Stimulation
23(34)
Manuela Rosa
Gaia Giannicola
Sara Marceglia
Manuela Fumagalli
Sergio Barbieri
Alberto Priori
1 Electric Field and Charge Distribution
25(2)
2 A Tool for Understanding the Functions of Human Deep Brain Structures
27(2)
3 Neurophysiology
29(12)
4 Behavioral Neurophysiology
41(1)
5 Neurochemistry
42(1)
6 Future Perspectives: Development of New Adaptive Deep Brain Stimulation (aDBS) Systems
43(14)
References
46(11)
4 Neurophysiology of Cortical Stimulation
57(30)
Jean-Pascal Lefaucheur
1 Introduction
58(1)
2 Basic Principles of TMS
58(2)
3 Repetitive Transcranial Magnetic Stimulation
60(1)
4 Theta Burst Stimulation
60(1)
5 Paired Associative Stimulation
61(1)
6 Transcranial Electrical Stimulation with Pulsed Currents
62(1)
7 Transcranial Direct Current Stimulation
62(2)
8 Implanted Cortical Stimulation
64(1)
9 Induced Currents into the Brain
65(1)
10 Comparisons Between the Methods of Stimulation
65(1)
11 Safety and Contraindications
66(1)
12 Neural Circuit Activation by Cortical Stimulation: Spatial Aspects
67(1)
13 Neural Circuit Activation by Cortical Stimulation: Temporal Aspects
68(1)
14 Plasticity and Priming
69(3)
15 Neuroprotection
72(1)
16 General Principles of the Therapeutic Efficacy of Cortical Stimulation
73(1)
17 Conclusion
74(13)
References
75(12)
5 Neural Mechanisms of Spinal Cord Stimulation
87(34)
Robert D. Foreman
Bengt Linderoth
1 Introduction
88(1)
2 Neuropathic Pain
89(6)
3 Peripheral Vascular Disease
95(5)
4 Visceral Diseases
100(3)
5 Cardiac Diseases
103(6)
6 Conclusions
109(12)
Acknowledgments
110(1)
References
110(11)
6 Magnetoencephalography and Neuromodulation
121(16)
Alfons Schnitzler
Jan Hirschmann
1 Introduction
121(1)
2 MEG and TMS
122(3)
3 MEG and Transcranial Direct or Alternate Current Stimulation
125(1)
4 MEG and DBS
125(7)
5 Conclusions and Outlook
132(5)
References
133(4)
7 Current Challenges to the Clinical Translation of Brain Machine Interface Technology
137(24)
Charles W. Lu
Parag G. Patil
Cynthia A. Chestek
1 Introduction and Motivation
137(4)
2 Device Hardware
141(6)
3 Performance
147(2)
4 Surgical Considerations
149(3)
5 Conclusion
152(9)
References
152(9)
8 Nanotechnology in Neuromodulation
161(24)
Russell J. Andrews
1 Introduction
162(1)
2 Nanotechniques: Scale and Properties
163(1)
3 Fabricating Nanoelectrodes for Neuromodulation
164(4)
4 Neurochemical/Neurotransmitter Monitoring
168(7)
5 Computational Models and Nanoelectrodes
175(3)
6 Minimally Invasive Neuromodulation
178(2)
7 Nanopower to the Neuromodulators!
180(1)
8 Nanoneuromodulation
181(4)
References
183(2)
9 Optogenetic Neuromodulation
185(22)
Paul S. A. Kalanithi
Jaimie M. Henderson
1 Introduction
185(1)
2 Basics of Optogenetics
186(8)
3 Clinical Insights from Optogenetics
194(3)
4 Translational Optogenetics
197(3)
5 Conclusions
200(7)
References
201(6)
10 Diffusion Tensor Imaging and Neuromodulation: DTI as Key Technology for Deep Brain Stimulation
207(28)
Volker Arnd Coenen
Thomas E. Schlaepfer
Niels Allert
Burkhard Madler
1 Overview
208(3)
2 Diffusion Weighted and Diffusion Tensor Magnetic Resonance Imaging
211(3)
3 Fiber Tractography
214(1)
4 Deterministic and Probabilistic Fiber Tracking
215(2)
5 Accuracy of Diffusion Tensor Imaging Fibertracking and Its Use in Neurosurgery
217(1)
6 Electric Field Simulation
218(1)
7 Applications
219(3)
8 Development of a New Target Region Utilizing the DTI Technique: A New DBS Target to Treat Major Depression
222(3)
9 DTI FT and the Concept of Network Balances
225(2)
10 Summary
227(8)
Acknowledgments
229(1)
References
229(6)
11 Multimodal Imaging and Image Analysis Techniques for Neuromodulation
235(18)
M. Mallar Chakravarty
1 Introduction
236(2)
2 Digital Atlases of Subcortical Structures
238(5)
3 Anatomical Image Acquisition Techniques for Planning DBS Procedures
243(1)
4 Functional Magnetic Resonance Imaging for Planning DBS Procedures
244(2)
5 Future Perspectives and Multimodal Integration
246(7)
References
246(7)
12 DBS and Electrical Neuro-Network Modulation to Treat Neurological Disorders
253(30)
Amanda Thompson
Takashi Morishita
Michael S. Okun
1 Introduction
254(1)
2 ENM in the Treatment of Chronic Pain
255(5)
3 Electrical ENM Approaches to Movement Disorders
260(8)
4 ENM in Epilepsy
268(3)
5 Conclusions
271(12)
References
272(11)
13 Neuromodulation in Psychiatric Disorders
283(32)
Yasin Temel
Sarah A. Hescham
Ali Jahanshahi
Marcus L. F. Janssen
Sonny K. H. Tan
Jacobus J. van Overbeeke
Linda Ackermans
Mayke Oosterloo
Annelien Duits
Albert F. G. Leentjens
LeeWei Lim
1 Introduction
284(1)
2 Neuromodulation in Addiction
285(4)
3 Neuromodulation in Alzheimer's Disease
289(3)
4 Neuromodulation in Depression
292(3)
5 Neuromodulation in OCD
295(3)
6 Neuromodulation in TS
298(2)
7 Neuromodulation in Other Psychiatric Indications
300(1)
8 Conclusion
301(14)
References
302(13)
14 Ethical Aspects of Neuromodulation
315(18)
Christiane Woopen
1 Introduction
316(1)
2 Personal Integrity
317(6)
3 Clinical Integrity
323(3)
4 Scientific Integrity
326(3)
5 Conclusion
329(4)
Acknowledgments
330(1)
References
330(3)
Subject Index 333(10)
Contents of Recent Volumes 343
Dr. Clement Hamani is the Research Director of the Hurvitz Brain Sciences Program, Senior Scientist at the Sunnybrook Research Institute, Full Professor in Surgery/Neurosurgery at the University of Toronto, preclinical lead of the Harquail Centre for Neuromodulation, and neurosurgeon at the Sunnybrook Health Sciences Centre in Toronto, Canada. Dr. Hamanis research focus is the development of new ways of modulating the function of the nervous tissue, and discovering new applications for techniques that stimulate the brain and spinal cord to treat neurological and psychiatric disorders. His work ranges from basic research in preclinical models to clinical trials.

Dr. Elena Moro graduated in Medicine at the University of Trieste (Italy) in 1989 and completed her residency in Neurology at the Catholic University in Rome (Italy) in 1996. She received her PhD in Neurosciences from the Catholic University in Rome, after having spent one and a half years in Grenoble, France (Joseph Fourier University), where she worked under the supervision of Dr. P. Pollak and Dr. A.L. Benabid. For her doctoral research Dr. Moro studied the response to levodopa and the electrical parameters of stimulation in parkinsonian patients with subthalamic nucleus deep brain stimulation.

From 2000 to 2002 she moved to Milan (Italy) in order to start and develop a surgical team for Movement Disorders at the Niguarda Ca Granda Hospital. In 2002, she joined the Division of Neurology at the University of Toronto (Canada) as an Assistant Professor, and medical Director of the surgical program for Movement Disorders at the Toronto Western Hospital. She worked with Dr. A.M. Lozano and Dr. A.E. Lang. She was promoted to Associate Professor of Neurology of the Faculty of Medicine, University of Toronto, in 2009. In 2012 she moved to Grenoble, France, as Professor of Neurology at the Joseph Fourier University (CHU Grenoble).

She is currently investigating the effects of DBS on gait in parkinsonian and dystonic patients, the role of the superior colliculus as biomarker in Parkinsons disease and the effects of the pedunculopontine nucleus stimulation. She is also responsible of the neurology teaching for undergraduate students and residents in neurology at the Faculty of Medicine of the Joseph Fourier University. She has so far published 108 scientific papers cited in PubMed and she has been an invited speaker to more than 100 international scientific meetings.