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end of medicine as we know it - and why your health has a future 2022 ed. [Hardback]

  • Formāts: Hardback, 291 pages, height x width: 235x155 mm, weight: 685 g, 34 Illustrations, black and white; XIV, 291 p. 34 illus., 1 Hardback
  • Izdošanas datums: 04-May-2022
  • Izdevniecība: Springer Nature Switzerland AG
  • ISBN-10: 3030952924
  • ISBN-13: 9783030952921
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  • Formāts: Hardback, 291 pages, height x width: 235x155 mm, weight: 685 g, 34 Illustrations, black and white; XIV, 291 p. 34 illus., 1 Hardback
  • Izdošanas datums: 04-May-2022
  • Izdevniecība: Springer Nature Switzerland AG
  • ISBN-10: 3030952924
  • ISBN-13: 9783030952921
Citas grāmatas par šo tēmu:
Medicine itself is sick. We hardly understand any disease and therefore need to chronically treat symptoms but not the causes. Consequently, drugs and other therapies help only very few patients; yet we are pumping more and more money into our healthcare system without any added value.Thus, the internationally renowned physician researcher, Harald Schmidt, predicts the end of medicine as we know it. On a positive note, digitization will radically change healthcare and lead to one of the greatest socioeconomic revolutions of mankind. He is one of the pioneers of "systems medicine", a complete redefinition of what we actually call a "disease", how we organize medicine and how we use Big Data to heal rather than treat, to prevent rather than cure. In this book the author first proves the deep crisis of medicine, but describes how medicine will become more precise, more uniform, safer and, surprisingly, also more affordable. Making a diagnosis will be taken over by artificial intelligence. Current, mainly organ-based medical specialists, disciplines and hospital departments will disappear. Physicians will become patient coaches working in interdisciplinary teams with pharmacists, physiotherapists, nutritionists, etc. and relieved of their workload. Illnesses, including cancer, will be prevented or cured in a precise manner. We will become 100 years and older. Health care spending will shift from chronic treatment of diseases to prevention and health maintenance, thereby dramatically reducing overall costs. Health will become a common good. But Harald Schmidt also warns that those who are not open to digitization will not benefit from these advances and will be left behind. Anyone who wants to benefit from the revolution of medicine must have a digital twin. Is this futurism? No, each of us can have his or her personal genome sequenced, microbiome analyzed, keep an electronic health record. The future has begun.Schmidt convincingly explains the limitations in the current practice of medicine and the need for big data and a systems approach. Prof. Ferid Murad MD, PhD, Nobel Laureate in Medicine 1998, USA 

Network Medicine, a new discipline that offers a network-based understanding of the cell and disease, is unavoidable if we wish to translate the advances in genomics into cures. Professor Harald Schmidt, a prominent expert in this space, offers the first coherent treatment of the topic, explaining the potential of a network-based perspective of human disease. Prof. Albert-Lįszló Barabįsi, Northeastern University and Harvard Medical School, Boston, USA

Visionary, provocative, and full of insights. Professor Schmidt gives a unique and authoritative perspective to the past, present and future of medical science and clinical practice. And all presented in such an inimitable style. Prof. Robert F.W. Moulds, MBBS PhD FRACP, Former Dean Royal Melbourne Hospital Clinical School, Australia
Part I Crisis, What Crisis...?
1 Too Late
3(10)
Crisis, What Crisis?
5(2)
We Have a Disease System
7(3)
All Are Satisfied
10(3)
2 Don't Rely on Your Prescription
13(18)
The Number Needed to Treat
17(2)
Absolute and Relative Risk
19(3)
New Drugs Mostly Without Any Benefit
22(2)
Pseudo-Innovative "Me Too" Drugs
24(2)
Polypharmacy or Polymedication
26(5)
3 Chronic Disease?
31(8)
Chronic Sickness Costs Quality of Life
32(1)
Chronic Illness Shortens Life
33(2)
Mortality Is on the Rise
35(1)
More Money? No
36(3)
4 No Prevention
39(22)
Hardly Real Prevention
42(1)
Check-Ups with the Family Doctor Useless
43(2)
Check-Ups at the Dentist Useless
45(4)
Diabetes and the Sugar Scandal
49(6)
Red Meat
55(1)
Alcohol
56(1)
Vegetables and Fresh Fruit
57(1)
Movement Plus Strength Plus Agility
58(1)
Psyche: Sleep Plus Stress
59(1)
What to Do?
60(1)
5 Male Plus Low Income = Double Whammy
61(10)
Uneducated = Minus 10
61(2)
Male = Minus 5
63(4)
Uneducated + Male = Minus 15
67(4)
6 False Incentives
71(18)
Universal Health Coverage
72(1)
The Loser Is
73(1)
Only 1% for Prevention
74(1)
Why Germany Was So Well "Prepared" for COVID-19
75(5)
Even Dying Isn't Easy
80(2)
The Surgery Boom
82(4)
USA: The Extreme Case
86(3)
7 The End of Big Pharma
89(12)
The Costs Explode
90(1)
Hardly Any Innovations
90(2)
Limited Growth and Terminal Decline
92(5)
Big Pharma in Court
97(4)
8 Research Not for Patients
101(18)
Research Output = Paper
102(3)
Fee for Service
105(1)
Not Reproducible
106(2)
Significant!?
108(2)
The Drawer Effect
110(1)
Quality Defects
111(1)
Withdrawn!
112(2)
COVID-19 Research
114(2)
Predatory Journals, Nonsense Papers, and the Eightfold Publication
116(3)
9 Organ-Based Medicine
119(10)
Rare Diseases as a Model
121(2)
The Organ Boundaries Are Falling
123(2)
Redefining Autoimmune Diseases
125(1)
Asthma ≠ Asthma
126(3)
10 Interjection 1: How Healthy Do You Want to Be?
129(8)
Part II The Medicine of the Future
11 Re-discover the Whole Patient
137(18)
Wave #6
137(3)
IT Platforms Join in
140(4)
How Big Data Is Helping to Redefine Diseases
144(7)
From Symptom to Cause
151(4)
12 Research for Patients
155(10)
A New Way to Research
155(6)
A New Way to Publish
161(4)
13 Know your Genes
165(12)
Why Is your DNA So Unique?
165(1)
The Genetic Diagnostics Act
166(1)
DNA Genealogy
167(3)
Your Personal Genome
170(3)
Personal "Omes"
173(4)
14 Outnumbered
177(12)
Excessive Hygiene
178(1)
Your Gut Microbiome
179(2)
Prebiotics and Probiotics
181(1)
Stool Transplant
182(2)
Does the Wrong Gut Flora Make you Fat?
184(1)
The Gut-Heart and Gut-Brain Axis, Respectively
185(2)
Postbiotics, the Real Future?
187(2)
15 Your Exposome
189(12)
What Is your Exposome?
190(2)
How to Measure your Exposome?
192(1)
Exposome in Practice
193(1)
The Exposome Economy
194(2)
From Exposome to Prevention
196(1)
Your Data
197(1)
Financial Incentives
198(3)
16 Big Data Medicine
201(16)
How Does Machine Learning Work?
202(3)
Trendsetters Radiology and Oncology
205(2)
Machine Learning Pervades all of Medicine
207(2)
Apple Watch and Smartphone
209(2)
Machine Learning Overcomes Wealth Gap
211(1)
The New Doctor-Patient Relationship
212(1)
Algorithms Make Mistakes, So Do Doctors
213(1)
Where Are the Hurdles?
214(3)
17 Healed
217(20)
How to Cure Complex Diseases
218(3)
The Special Case of Monogenic, Rare Diseases
221(1)
Principles of Gene Therapy
222(2)
Substituting the Gene Product, the Protein
224(1)
Gene Therapy Stage 1, outside the Body
225(2)
Whole-Body Gene Therapy
227(4)
Germline Gene Therapy?
231(2)
Live Forever?
233(4)
18 Well-Tech
237(20)
New Health Companies
238(4)
Health beyond Medicine
242(1)
Well-being by Well-Tech
243(3)
Beware Self-Optimization
246(2)
A New Health System
248(5)
Quality Instead of Quantity
253(4)
19 Interjection 2: Superhumans
257(6)
Part III The Future Has Begun...
20 Self-Diagnosis
263(6)
21 Self-Therapy
269(10)
Nudging
271(2)
Apps on Prescription
273(6)
22 Your Digital Twin
279(6)
Drug Safety
280(3)
Patients like us
283(2)
Epilogue: Nobody is Sick Anymore 285(4)
Appendix A Special Page 1 289(2)
Appendix B Special Page 2 291
Professor Harald H.H.W. Schmidt is a German physician and pharmacist, chairing the Department of Pharmacology and Personalized Medicine, Faculty of Health, Medicine and Life Sciences, at the University of Maastricht. Netherlands.After his double degree in medicine and pharmacy, he distinguished himself as an internationally highly recognized researcher in the fields of drug therapy, elucidation of the causes of disease and prevention.He headed and heads various research programs as an Advanced Investigator of the European Research Council (ERC), coordinator of  Horizon 2020 project REPO-TRIAL and Collaboration on Science and Technology (COST) actions.He founded companies with which he brought therapeutics and diagnostics to market, is co-editor of the journal Network and Systems Medicine, and has written over 200 peer-reviewed international publications, reviews and books with a Hirsch factor of 92 and over 30,000 citations.Part of his early research training he conducted in the USA with the later Nobel Laureate, Ferid Murad, and led international institutes and research centers in Germany, Australia and the Netherlands. He is also the editor of a textbook on drug therapy and several expert handbooks in drug therapy.As a broadly experience and critical analyst, he recognized the fundamental conceptual crisis in medicine and became one of the pioneers of systems medicine, i.e. a complete redefinition of what we actually call a "disease", how we organize medicine and how we use Big Data to heal rather than treat and ideally to prevent diseases.He is a dedicated, international keynote speaker, podcaster, YouTuber and initiator of the German patientenwiewir.de patient platform. One of his hobbies is sports. For a long time, he was a soccer referee. His social engagement at Rotary International and different clubs introduced him to Homeless World Cup and sharpened is awareness and engagement for homeless people. Recently, his interested in sociocritical and political contemporary art recently started him to create his own small oeuvre under the concept of realitychanges.de, which has been selected for several solo and group exhibitions