This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks output.
In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms development.
Preface.- The endosomal network: mediators and regulators of endosome
maturation.- Integration of the endocytic system into the network of cellular
functions.- GTPases Rac1 and Ras signaling from endosomes.- ESCRT and
membrane protein ubiquitination.- Retromer and its role in regulating
signaling at endosomes.- The lysosome and intracellular signaling.- Interplay
of endocytosis and growth factor receptor signaling.- Role of the endocytosis
of caveolae in intracellular signaling and metabolism.- EGFR trafficking in
physiology and cancer.- Evolving view of membrane trafficking and signaling
systems for G protein-coupled receptors.- Endosomal trafficking during
mitosis and Notch-dependent asymmetric division.
