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Enzyme Technologies for Pharmaceutical and Biotechnological Applications [Hardback]

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  • Formāts: Hardback, 624 pages, height x width: 279x216 mm, weight: 794 g
  • Izdošanas datums: 05-Jun-2001
  • Izdevniecība: Marcel Dekker Inc
  • ISBN-10: 0824705491
  • ISBN-13: 9780824705497
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  • Hardback
  • Cena: 174,36 €
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  • Formāts: Hardback, 624 pages, height x width: 279x216 mm, weight: 794 g
  • Izdošanas datums: 05-Jun-2001
  • Izdevniecība: Marcel Dekker Inc
  • ISBN-10: 0824705491
  • ISBN-13: 9780824705497
Citas grāmatas par šo tēmu:
This reference provides a review of enzyme functions in human and animal health. It covers basic principles and applications in antibiotic biosynthesis, biocatalysis, and screening and assay optimization, as well as new and emerging technologies in the biotechnological and pharmaceutical industries. Emphasizing modern methods of metabolic engineering and drug discovery processes, the book details enzyme targets related to human disease. It also discusses effective enzymatic assays, high-throughput screening, novel compounds for lead generation, improvements in antibiotic yield, and the generation of contemporary protein products. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Preface iii
Contributors xi
I. Biosynthesis
δ-(L-α-Aminoadipyl)-L-Cysteinyl-D-Valine Synthetase as a Model Tripeptide Synthetase
1(38)
Hans von Dohren
Wibke Kallow
Mary Anne Tavanlar
Torsten Schwecke
Ralf Dickmann
Volker Uhlmann
Metabolic Engineering for Cephalosporin C Yield Improvement and Production of Intermediates
39(22)
Joe E. Dotzlaf
Steven W. Queener
Wu-Kuang Yeh
Bioconversion of Penicillins to Cephalosporins
61(28)
Arnold L. Demain
Jose L. Adrio
Jacqueline M. Piret
Direct Fermentative Production of Acyltylosins by Genetically Engineered Strains of Streptomyces fradiae
89(24)
Akira Arisawa
Hiroshi Tsunekawa
Engineering Streptomyces avermitilis for the Production of Novel Avermectins: Mutant Design and Titer Improvement
113(24)
Claudio D. Denoya
Kim J. Stutzman-Engwall
Hamish A. I. McArthur
II. Biocatalysis
Biocatalytic Syntheses of Chiral Intermediates for Antihypertensive Drugs
137(38)
Ramesh N. Patel
Cloning, Structure, and Activity of Ketone Reductases from Baker's Yeast
175(34)
Jon D. Stewart
Sonia Rodriguez
Margaret M. Kayser
Cross-Linked Enzyme Crystals: Biocatalysts for the Organic Chemist
209(18)
Michael D. Grim
Enzymatic Deacylation of Echinocandins and Related Antifungal Agents
227(18)
Andrew R. Cockshott
Adam J. Kreuzman
Wu-Kuang Yeh
III. Screening/Optimization
Roles of Enzymes in Antibacterial Drug Discovery
245(18)
Siddhartha Roychoudhury
Penicillin-Binding Proteins as Antimicrobial Targets: Expression, Purification, and Assay Technologies
263(26)
Genshi Zhao
Timothy I. Meier
Wu-Kuang Yeh
Development of a High-Throughput Screen for Streptococcus pneumoniae UDP-N-Acetylmuramoyl-Alanine: D-Glutamate Ligase (MurD) for the Identification of MurD Inhibitors Michele C. Smith
289(18)
James A. Cook
Gary M. Birch
Stephen A. Hitchcock
Robert B. Peery
Joann Hoskins
Paul L. Skatrud
Raymond C. Yao
Karen L. Cox
Purification and Assay Development for Human Rhinovirus Proteases
307(16)
Q. May Wang
Robert B. Johnson
Screening for Parasiticides Using Recombinant Microorganisms
323(20)
Timothy G. Geary
Screening for Inhibitors of Lipid Metabolism
343(36)
Hiroshi Tomoda
Satoshi Omura
Design and Development of a Selective Assay System for the Phospholipase A2 Superfamily
379(18)
Hsiu-Chiung Yang
Marian Mosior
Edward A. Dennis
IV. Emerging Technologies
Understanding and Exploiting Bacterial Polyketide Synthases
397(30)
Robert McDaniel
Chaitan Khosla
Polyketide Synthases: Analysis and Use in Synthesis
427(44)
Kira J. Weissman
James Staunton
Enzymatic Synthesis of Fungal N-Methylated Cyclopeptides and Depsipeptides
471(28)
Mirko Glinski
Till Hornbogen
Rainer Zocher
New Strategies for Target Identification, Validation, and Use of Enzymes in High-Throughput Screening
499(16)
Joaquim Trias
Zhengyu Yuan
Use of Genomics for Enzyme-Based Drug Discovery
515(22)
Molly B. Schmid
Assigning Precise Function to Genes
537(18)
Ridong Chen
Redesigning Binding and Catalytic Specificities of Enzymes
555(20)
Ridong Chen
Proteomics: Chromatographic Fractionation Prior to Two-Dimensional Polyacrylamide Gel Electrophoresis for Enrichment of Low-Abundance Proteins to Facilitate Identification by Mass Spectrometric Methods
575(22)
Srinivasan Krishnan
John E. Hale
Gerald W. Becker
Index 597