E-grāmata: Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agent

"This book highlights how, what, and where enzymes have become critical in pharmaceutical and biotechnology research. It provides in-depth reviews of recent developments in select topics on biosynthesis, biocatalysis, and chemical biology of enzymes. Broad coverage of enzymatic assays includes emerging assay technologies for key enzyme classes in pharmaceutical research. In addition to new developments in proteomics, this book includes two emerging technologies in Life Sciences: metabolomics (including glycomics and lipidomics) and preclinomics. This volume reviews important progress on the chemical biology of enzymes in the post-genomic era"--

Chemists and medical specialists explore enzymes as essential workhorses in pharmaceutical research, as indispensable tools for improving druggability, and as powerful weapons for correcting nature's errors. Their topics include discovering and developing isozyme-selected inhibitors involved in lipid metabolism, enzyme assays and rodent models of metabolic diseases, the evolution of an orally active prodrug of gencitabine, enzymatically activated phosphate and phosphonate prodrugs, and methods and principles of pancreatic function tests. Annotation ©2014 Ringgold, Inc., Portland, OR (protoview.com)

Sets the stage for advances in drug discovery using the latest enzyme technology

Reviewing new and emerging applications of enzyme technology in drug discovery, this book highlights some of the most promising areas of pharmaceutical and biotechnology research. It covers enzyme assay technology, utilization of enzymology for prodrug design, and the application of enzymes as therapeutic agents. Expert reviews highlight how our latest understanding of enzymology is used to develop new practical applications in drug discovery and design.

Filled with case studies, Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents enables readers to better understand the diverse functions of enzymes and master specific applications in drug discovery research. In addition to small molecule drug discovery, the book explores new developments in enzymes as therapeutic agents for genetic disorders.

• Section A, Enzymes ? Essential Workhorses in Pharmaceutical Research, offers support in selecting the best enzyme targets for drug discovery, designing enzyme inhibitors for therapeutic agents, and evaluating selective enzyme inhibitors.
• Section B, Enzymes ? Indispensable Tools for Improving Druggability, sets forth the principles alongside real-world examples of exploiting specific properties of enzymes to design successful prodrugs.
• Section C, Enzymes ? Powerful Weapons for Correcting Nature's Errors, provides new insights on applying enzymes as therapeutic agents or diagnostic tools to treat genetic disorders.

Chapters are contributed by leading experts from around the world. Their contributions are based on a thorough review of the current literature as well as their own research.

Reviewing our latest understanding of the nature of enzymes and their role in drug discovery, this book is recommended for researchers in pharmaceuticals and biotechnology as well as for researchers in enzymology, biochemistry, molecular biology, and medicinal chemistry.