Contributors |
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ix | |
Preface |
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xi | |
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1 Plasmodium vivax: Modern Strategies to Study a Persistent Parasite's Life Cycle |
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1 | (26) |
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2 | (1) |
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2 The General Life Cycle of Plasmodium vivax and Other Primate Malaria Parasite Species |
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3 | (8) |
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3 In Vitro and Ex Vivo Models for Examining P. vivax Biology |
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11 | (3) |
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4 Neotropical Non-Human Primate Models (New World Monkeys) for Investigating the Varied Biology of vivax Malaria |
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14 | (1) |
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5 The Relapsing Malaria Parasites of Southern Asian Macaque Monkeys as Models for P. vivax Biology |
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15 | (2) |
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6 From Genomics to Systems Biology: The Bigger Picture Puzzles |
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17 | (3) |
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20 | (7) |
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20 | (1) |
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20 | (7) |
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2 Red Blood Cell Polymorphism and Susceptibility to Plasmodium vivax |
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27 | (50) |
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28 | (1) |
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2 The Era of Great Biological Discovery |
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29 | (6) |
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3 Resistance to P. vivax and Insights on Malaria Red Cell Invasion |
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35 | (12) |
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4 Evolving Perspectives on Resistance to P. vivax |
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47 | (13) |
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5 Conclusions and Future Directions |
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60 | (17) |
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65 | (1) |
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65 | (12) |
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3 Natural Acquisition of Immunity to Plasmodium vivax: Epidemiological Observations and Potential Targets |
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77 | (56) |
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1 Overview of Naturally Acquired Immunity to Malaria |
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78 | (3) |
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2 Differential Acquisition of Immunity to P. vivax and P. falciparum Under Natural Exposure |
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81 | (3) |
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3 Acquisition of Immunity in Experimental Infections--Lessons from Malaria Therapy Patients and Irradiated Sporozoites |
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84 | (4) |
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4 Unique Biological Characteristics of P. vivax that Contribute to NAI |
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88 | (5) |
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5 Effector Mechanisms for Blood-Stage Immunity |
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93 | (1) |
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6 Targets of Blood-Stage Immunity |
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94 | (12) |
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7 Immune Responses to Malaria Pre-Erythrocytic Stages |
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106 | (5) |
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8 Sexual Stage Parasites and Transmission-Blocking Immunity |
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111 | (3) |
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114 | (1) |
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114 | (19) |
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115 | (18) |
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4 G6PD Deficiency: Global Distribution, Genetic Variants and Primaquine Therapy |
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133 | (70) |
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135 | (1) |
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136 | (7) |
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3 Glucose-6-Phosphate Dehydrogenase Deficiency: The Enzyme and Its Gene |
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143 | (7) |
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4 Diagnosing G6PD Deficiency |
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150 | (5) |
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5 Mapping the Spatial Distribution of G6PD Deficiency |
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155 | (9) |
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6 Spatial Co-occurrence of G6PD Deficiency with P. vivax Endemicity |
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164 | (6) |
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7 Evolutionary Drivers of the Distribution of G6PD Deficiency |
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170 | (4) |
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8 Primaquine, P. vivax and G6PD Deficiency |
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174 | (11) |
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9 Towards a Risk Framework for P. vivax Relapse Treatment |
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185 | (5) |
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190 | (13) |
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191 | (1) |
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192 | (11) |
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5 Genomics, Population Genetics and Evolutionary History of Plasmodium vivax |
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203 | (20) |
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1 The Importance of Studying Plasmodium Diversity |
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204 | (1) |
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2 The Evolutionary History of P. vivax |
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204 | (3) |
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3 The P. vivax Genome and Comparative Genomics |
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207 | (6) |
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4 P. vivax Global Genetic Diversity and Population Structure |
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213 | (2) |
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5 P. vivax Population Genetics in India |
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215 | (3) |
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218 | (5) |
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218 | (1) |
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219 | (4) |
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6 Malariotherapy--Insanity at the Service of Malariology |
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223 | (34) |
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224 | (1) |
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2 The Era of Malariotherapy |
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225 | (3) |
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3 The Practice of Malariotherapy |
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228 | (1) |
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4 Malariatherapy and Malariology |
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229 | (4) |
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5 Malariotherapy's Major Contributions to Malariology |
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233 | (8) |
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6 Lessons from Malariotherapy: Caveats and Current Relevance |
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241 | (4) |
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245 | (12) |
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245 | (12) |
Index |
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257 | |