Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms.
Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics.
- Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations
- Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers
- Features chapter contributions from international researchers in the field
Recenzijas
"I believe this to be the first of many textbooks on this topic. It is a much-needed summary of important advancements in the field of epigenetics and reproductive health. It is a very detailed review intended for expects in the field and those devoted to continued research in this area." --Doody
SECTION I Spermatogenesis, oogenesis and fertility
1. Epigenome reprogramming in the male and female germ line
2. Genomic imprinting
3. Chromatin remodeling of the male genome during spermiogenesis and embryo
development
4. Epigenetic regulation in stem cells
5. Aberrant epigenetics and reproductive disorders
SECTION II Pregnancy/developmental/placental epigenetics
6. Epigenetic reprogramming in the embryo
7. Epigenetic regulation during placentation
8. Epigenetic modulation during pregnancy and pregnancy related disorders
9. Epigenetic involvement in fetal and neonatal origins of late-onset
disease
SECTION III Epigenetic lifestyle, aging and environmental influence
10. Impact of environmental chemicals and endocrine disruptors on mammalian
germ cell epigenome
11. Influence of nutrition on reproductive health through epigenetic
mechanisms
12. Influence of stress and lifestyle on epigenetic modifications
13. Aging of male and female gametes
SECTION IV Reproductive cancer and epigenetics
14. Testicular and prostate cancers
15. Emerging patterns and implications of breast cancer epigenetics: An
update of the current knowledge
16. Ovarian and endometrial cancers
17. Epigenetic aberrations in cervical cancer
SECTION V Epigenetics in diagnosis, prognosis and therapy
18. Natural molecules as epigenetic modifiers in reproduction
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the ONeal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelors degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. Dr. Nafisa Balisinor received her B.Sc. and M.Sc. at the Sophia College University of Mumbai, and her Ph.D. at the Institute for Research in Reproduction, University of Bombay (Biochemistry, 1989). She has published widely on topics in reproductive neuroendocrinology and epigenetics, in such peer reviewed journals as the International Journal of Biological Macromolecules, Epigenetics, Endocrinology, Andrologia, and the Journal of Steroid Biochemistry and Molecular Biology. Currently Dr. Nafisa Balasinor is a Scientist and Head of the Department of Neuroendocrinology, at the National Institute for Research in Reproductive Health India, Mumbai, India. Dr. Priyanka Parte received her first M.Sc. at the University of Mumbai (Applied Biology, 1992), and her second M.Sc at the University of Edinburgh , Scotland , U.K. (Reproductive Biology; 1996). She received her Ph.D. at the University of Mumbai, (Biochemistry, 2000), followed by a Post-Doctoral fellowship at the University of Massachusetts, Worcester (Biochemistry & Mol. Pharmacology.; 2003-2004). Currently, she is a Scientist and Head of the Department of Gamete Immunobiology at the National Institute for Research in Reproductive Health India, Mumbai, India. She has published articles in such peer reviewed journals as Fertility and Sterility, Cell and Tissue Research, Molecular Reproduction and Development, and the Journal of Proteomics. Dr. Dipty Singh received her Ph.D at the University of Mumbai (Life Sciences, 2010), and her M.Sc at the University of Allahabad (Biotechnology, 2004). Her research interests include reproductive biology, endocrine disruptors, and bacterial cell division proteins and their small molecule inhibitors. In her previous role she was a Research Associate at the Department of Biosciences & Bioengineering, IIT Mumbai, and is now a Scientist at the National Institute for Research in Reproductive Health India, Mumbai, India. She has published a range of peer journals, including Biochemistry, Chemosphere, the Journal of Pharmacopuncture, and the Journal of Nanobiotechnology.
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