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E-grāmata: Essentials of Stem Cell Biology

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Edited by , Edited by , Edited by (Astellas Institute for Regenerative Medicine, Westborough, MA, USA), Edited by (Johns Hopkins University School of Medicine, Baltimore, MD, USA), Edited by (Duke University Medical Center, Durham, NC, USA), Edited by (Howard Hughes Medical Institute, Harvard Univer), Edited by , Edited by
  • Formāts: EPUB+DRM
  • Izdošanas datums: 05-Jun-2009
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780080884974
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Essentials of Stem Cell BiologyPalielināt
  • Formāts: EPUB+DRM
  • Izdošanas datums: 05-Jun-2009
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780080884974
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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.

* Contributions by Nobel Laureates and leading international investigators
* Includes two entirely new chapters devoted exclusively to iPS written by the scientists who made the breakthroug
* Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate

First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.
  • Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries
  • Contributions by Nobel Laureates and leading international investigators
  • Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough
  • Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate
  • Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references
Contributors ix
Preface xv
Robert Lanza
Foreword xvii
Sir Martin Evans
Nobel Laureate
Why Stem Cell Research xix
Alan Trounson
A New Path: Induced Pluripotent Stem Cells xxi
Shinya Yamanaka
``Stemness'': Definitions, Criteria, and Standards xxiii
Douglas A. Melton
Chad Cowen
Part I Introduction to Stem Cells
1(36)
Pluripotential Stem Cells from Vertebrate Embryos: Present Perspective and Future Challenges
3(10)
Richard L. Gardner
Embryonic Stem Cells in Perspective
13(4)
Janet Rossant
The Development of Epithelial Stem Cell Concepts
17(12)
Christopher S. Potten
J. W. Wilson
Direct Reprogramming of Somatic Cells to a Pluripotent State
29(4)
Dirk Hockemeyer
Frank Soldner
Rudolf Jaenisch
Clinical Translation of Stem Cells
33(4)
Olle Lindvall
Part II Basic Biology/ Mechanisms
37(80)
Molecular Bases of Pluripotency
39(22)
Fatima Cavaleri
Hans Scholer
Stem Cell Niches
61(12)
D. Leanne Jones
Margaret T. Fuller
Mechanisms of Stem Cell Self-renewal
73(8)
Hitoshi Niwa
Cell Cycle Regulators in Adult Stem Cells
81(8)
Tao Cheng
David T. Scadden
Epigenetic Mechanisms of Cellular Memory During Development
89(16)
Nathan Montgomery
Terry Magnuson
Scott Bultman
Cell Fusion and the Differentiated State
105(6)
Penny Johnson
Peter W. Andrews
How Cells Change Their Phenotype
111(6)
David Tosh
Marko E. Horb
Part III Tissue and Organ Development
117(212)
Differentiation in Early Development
119(12)
Susana M. Chuva de Sousa Lopes
Christine L. Mummery
Primordial Germ Cells in Mouse and Human
131(6)
Anne McLaren
Susana M. Chuva de Sousa Lopes
Stem Cells in Extraembryonic Lineages
137(8)
Tilo Kunath
Janet Rossant
Amniotic Fluid-Derived Pluripotential Cells
145(6)
Anthony Atala
Cord Blood Hematopoietic Stem and Progenitor Cells
151(6)
Hal E. Broxmeyer
Neurogenesis in the Vertebrate Embryo
157(12)
Chris Kintner
Naoko Koyano-Nakagawa
The Nervous System
169(10)
Lorenz Studer
Neuronal Progenitors in the Adult Brain: From Development to Regulation
179(6)
Christian Mirescu
Elizabeth Gould
Sensory Epithelium of the Eye and Ear: Update of Retinal Stem Cell Research 2003 to the Present
185(4)
Connie Cepko
Donna Fekete
Epithelial Hair Follicle Stem Cells
189(10)
Tudorita Tumbar
Elaine Fuchs
The Ontogeny of the Hematopoietic System
199(12)
Malcolm A. S. Moore
Hematopoietic Stem Cells
211(6)
George Q. Daley
Red Blood Cells
217(6)
Shi-Jiang Lu
Jennifer S. Park
Qiang Feng
Robert Lanza
Cell Differentiation in the Skeleton
223(4)
Gerard Karsenty
Human Vascular Progenitor Cells
227(6)
Ayelet Dar
Sharon Gerecht-Nir
Joseph Itskovitz-Eldor
Multipotent Adult Progenitor Cells
233(10)
Catherine M. Verfaillie
Annelies Crabbe
Mesenchymal Stem Cells
243(6)
Arnold I. Caplan
Skeletal Muscle Stem Cells
249(10)
Helen M. Blau
Alessandra Sacco
Penney M. Gilbert
Stem Cells and the Regenerating Heart
259(6)
Maria Paola Santini
Bhawana Poudel
Nadia Rosenthal
Potential of Embryonic and Induced Pluripotent Stem Cell Differentiation Culture for Vascular Biology
265(8)
Jun K. Yamashita
Satomi Nishikawa
Shinichi Nishikawa
Cell Lineages and Stem Cells in the Embryonic Kidney
273(12)
Gregory R. Dressler
Adult Liver Stem Cells
285(14)
Markus Grompe
Pancreatic Stem Cells
299(8)
Yuval Dor
Douglas A. Melton
Stem Cells in the Gastrointestinal Tract
307(22)
Stuart A. C. McDonald
Trevor A. Graham
Adam Humphries
Nicholas A. Wright
Sean L. Preston
Mairi Brittan
Natalie C. Direkze
Part IV Methods
329(138)
Induced Pluripotent Stem Cell Derivation
331(8)
Junying Yu
James A. Thomson
Characteristics and Characterization of Human Pluripotent Stem Cells
339(6)
Anne G. Bang
Melissa K. Carpenter
Isolation and Maintenance of Murine Embryonic Stem Cells
345(6)
Martin Evans
Isolation, Characterization and Maintenance of Primate Embryonic Stem Cells
351(14)
Michal Amit
Joseph Itskovitz-Eldor
Approaches for Derivation and Maintenance of Human Embryonic Stem Cells: Detailed Procedures and Alternatives
365(16)
Irina Klimanskaya
Jill McMahon
Derivation and Differentiation of Human Embryonic Germ Cells
381(10)
Michael J. Shamblott
Candace L. Kerr
Joyce Axelman
John W. Littlefield
Gregory O. Clark
Ethan S. Patterson
Russell C. Addis
Jennifer N. Kraszewski
Kathleen C. Kent
John D. Gearhart
Growth Factors and the Serum-free Culture of Human Pluripotent Stem Cells
391(6)
Alice Pebay
Martin F. Pera
Feeder-free Culture
397(12)
Holly Young
Tom Schulz
Melissa K. Carpenter
Genetic Manipulation of Human Embryonic Stem Cells
409(8)
Yoav Mayshar
Nissim Benvenisty
Homologous Recombination in Human Embryonic Stem Cells
417(6)
Thomas P. Zwaka
James A. Thomson
Surface Antigen Markers
423(6)
Jonathan S. Draper
Peter W. Andrews
Lineage Marking
429(8)
Andras Nagy
Genomic Reprogramming
437(6)
M. Azim Surani
Isolation and Characterization of Hematopoietic Stem Cells
443(6)
Gerald J. Spangrude
William B. Slayton
Microarray Analysis of Stem Cells and Differentiation
449(10)
Howard Y. Chang
Xin Chen
Zebrafish and Stem Cell Research
459(8)
Emily K. Pugach
K. Rose Finley
Leonard I. Zon
Part V Applications
467(132)
Cancer Stem Cells
469(16)
Michael Rothenberg
Michael F. Clarke
Neural Stem Cells for Central Nervous System Repair
485(12)
Rodolfo Gonzalez
Jean Pyo Lee
Evan Y. Snyder
Spinal Cord Injury
497(10)
John W. McDonald
Daniel Becker
Use of Embryonic Stem Cells to Treat Heart Disease
507(6)
Michael Rubart
Loren J. Field
Insulin-producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes
513(10)
Susan Bonner-Weir
Gordon C. Weir
Burns and Skin Ulcers
523(6)
Edward Upjohn
George Varigos
Pritinder Kaur
Stem Cells and Heart Disease
529(14)
Annarosa Leri
Piero Anversa
Jan Kajstura
Stem Cells for the Treatment of Muscular Dystropy: Therapeutic Perspectives
543(8)
Maurilio Sampaolesi
Giulio Cossu
Regeneration of Epidermis from Adult Keratinocyte Stem Cells
551(10)
Ariane Rochat
Yann Barrandon
Orthopedic Applications of Stem Cells
561(10)
Jerry I. Huang
Victor M. Goldberg
Embryonic Stem Cells in Tissue Engineering
571(12)
Shulamit Levenberg
Ali Khademhosseini
Robert Langer
Postnatal Stem Cells in Tissue Engineering
583(8)
Pamela Gehron Robey
Paolo Bianco
Stem Cell Gene Therapy
591(8)
Brian R. Davis
Nicole L. Prokopishyn
Part VI Regulation and Ethics
599(38)
Ethical Considerations
601(8)
Ronald M. Green
Stem Cell Research:Religious Considerations
609(10)
Margaret A. Farley
Stem Cell-based Therapies: Food and Drug Administration Product and Pre-Clinical Regulatory Considerations
619(12)
Donald W. Fink
Steven R. Bauer
It's Not About Curiosity, It's About Cures: People Help Drive Progress
631(6)
Mary Tyler Moore
S. Robert Levine
Index 637
Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the 100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. Hes a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the worlds first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans. Sir Ian Wilmut is an embryologist who famously led the team that successfully cloned Dolly the sheep in the mid-1990s. To achieve this technical feat, the team established a technique for transferring nuclei from adult sheep cells to unfertilized sheep eggs that had had their own nuclei removed. He now conducts research on adult cells, using techniques that avoid the need to obtain embryonic cells. Ians current work aims to convert skin cells into stem cells that have the ability to form all tissues. By deriving these cells from donors who have inherited degenerative diseases, it is possible to gain new understanding of how diseases arise and search for medicines that are able to prevent the degeneration. In the long run, stem cells will be used in new treatments. Ian is a strong advocate of a proposal to develop a global network of cell banks, making it possible for anyone in the world to have access to such cell therapy.
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