Fermentation Microbiology and Biotechnology, 4th Edition explores and illustrates the broad array of metabolic pathways employed for the production of primary and secondary metabolites, as well as biopharmaceuticals. This updated and expanded edition addresses the whole spectrum of fermentation biotechnology, from fermentation kinetics and dynamics to protein and co-factor engineering. It also sheds light on the new strategies employed by industrialist for increasing tolerance and endurance of microorganisms to the accumulation of toxic wastes in microbial-cell factories. The new edition builds upon the fine pedigree of its earlier predecessors and extends the spectrum of the book to reflect the multidisciplinary and buoyant nature of this subject area.
Key Features
Covers the whole spectrum of the field from fermentation kinetics to control of fermentation and protein engineering.
Includes case studies specifically designed to illustrate industrial applications and current state-of-the-art technologies.
Presents the contributions of eminent international academics and industrial experts.
Offers new chapters addressing:
The prospects and the role of bio-fuels refineries,
Control of metabolic efflux to product formation in microbial-cell factories and
Improving tolerance of microorganisms to toxic byproduct accumulation in the fermentation vessel.
| Preface |
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xi | |
| Acknowledgments |
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xiii | |
| Editors |
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xv | |
| Contributors |
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xvii | |
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SECTION I Fermentation Microbiology and Biotechnology: Central and Modern Concepts |
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Chapter 1 Fermentation Microbiology and Biotechnology: An Historical Perspective |
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3 | (6) |
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Chapter 2 Microbiology of Industrial Fermentation: Central and Modern Concepts |
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9 | (22) |
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Chapter 3 Fermentation Kinetics: Central and Modern Concepts |
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31 | (26) |
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SECTION II Fermentation Microbiology and Biotechnology: Control of Carbon Flux to Product Formation in Microbial Cell Factories |
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Chapter 4 Microbial Synthesis of Primary Metabolites: Current Trends and Future Prospects |
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57 | (18) |
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Chapter 5 Microbial Synthesis of Secondary Metabolites and Strain Improvement: Current Trends and Future Prospects |
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75 | (16) |
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Chapter 6 Flux Control Analysis and Stoichiometric Network Modeling: Current Trends and Future Prospects |
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91 | (26) |
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Chapter 7 Control of Metabolite Efflux in Microbial Cell Factories: Current Advances and Future Prospects |
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117 | (24) |
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SECTION III Fermentation Microbiology and Biotechnology: Metabolic, Enzymatic, and Genetic Engineering of Microorganisms |
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Chapter 8 Increasing Tolerance and Robustness of Industrial Microorganisms: Current Strategies and Future Prospects |
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141 | (12) |
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Chapter 9 Engineering Microorganisms for the Production of Pharmaceutical Biomolecules: Current Trends and Future Prospects |
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153 | (14) |
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Chapter 10 Enzyme and Cofactor Engineering: Current Trends and Future Prospects in the Pharmaceutical and Fermentation Industries |
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167 | (22) |
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SECTION IV Fermentation Microbiology and Biotechnology: Bioconversion of Renewable Resources to Desirable End Products |
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Chapter 11 Conversion of Renewable Resources to Biofuels and Fine Chemicals: Current Trends and Future Prospects |
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189 | (32) |
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Chapter 12 Biorefineries: Industrial Perspectives and Challenges in Primary and Secondary Metabolism |
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221 | (22) |
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Chapter 13 Solid-State Fermentation: Current Trends and Future Prospects |
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243 | (14) |
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Lalitha Devi Gottumukkala |
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SECTION V Fermentation Microbiology and Biotechnology: Tools, Monitoring, and Control of Fermentation Processes |
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Chapter 14 Functional Genomics: Current Trends, Tools, and Future Prospects in the Fermentation and Pharmaceutical Industries |
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257 | (26) |
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Chapter 15 Bioreactors: Design, Operation, and Applications |
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283 | (26) |
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Chapter 16 Biosensors in Bioprocess Monitoring and Control: Current Trends and Future Prospects |
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309 | (14) |
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Chapter 17 Cell Immobilization and Its Applications in Biotechnology: Current Trends and Future Prospects |
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323 | (36) |
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Chapter 18 Recent Advances and Impacts of Microtiter Plate-Based Fermentations in Synthetic Biology and Bioprocess Development |
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359 | (14) |
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Chapter 19 Control and Monitoring of Industrial Fermentations: An Industrial Perspective and Recent Trends |
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373 | (40) |
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| Index |
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413 | |
Mansi El-Mansi has been on the faculty of Glasgow University, in Edinburgh, at Sharda University, India, and more recently at Elizade University, Nigeria. His research was the first to postulate and unravel the role of HS-CoA in the partition of carbon flux among enzymes of central metabolism during growth of Escherichia coli on acetate. He was also the first to provide evidence supporting Dan Kosahlands theory of "ultrasensitivity". His research activities, which span the best part of 30 years, yielded an extensive list of publications of which four are single-author publications in peer-reviewed journals. He is currently the Director of Science Education and Research at Bio-Ed, a United Kingdom based company.
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