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Forensic Histopathology: Fundamentals and Perspectives Second Edition 2018 [Hardback]

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  • Formāts: Hardback, 570 pages, height x width: 254x178 mm, 452 Illustrations, color; XXIII, 570 p. 452 illus. in color., 1 Hardback
  • Izdošanas datums: 30-May-2018
  • Izdevniecība: Springer International Publishing AG
  • ISBN-10: 3319779966
  • ISBN-13: 9783319779966
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Forensic Histopathology: Fundamentals and Perspectives Second Edition 2018Palielināt
  • Formāts: Hardback, 570 pages, height x width: 254x178 mm, 452 Illustrations, color; XXIII, 570 p. 452 illus. in color., 1 Hardback
  • Izdošanas datums: 30-May-2018
  • Izdevniecība: Springer International Publishing AG
  • ISBN-10: 3319779966
  • ISBN-13: 9783319779966
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9783319779966.html
Keywords:

Forensic Histopathology presents findings in forensic histology, immunohistochemistry, and cytology based on microscopic investigations. The text provides practitioners with detailed information and guidance on how microscopy can help to clarify the cause of sudden and unexpected death.



This second edition, which combines the features of an atlas and a textbook, presents findings in forensic histology, immunohistochemistry, and cytology based on microscopic investigations using different stainings and different antibodies. Questions of quality when working in the field of forensic histology are included as well as scientific perspectives for further research. The principal aim is to provide practitioners with detailed information and guidance on how microscopy can help to clarify the cause of sudden and unexpected death. Therefore additional and particularly rare histopathological findings are presented. Many of the topics will be of interest not only to forensic pathologists but also to general pathologists, whether practitioners or researchers. Examples include the pathology of drug abuse, wound age determination, adverse drug reactions, histopathology of the sudden infant death syndrome, and age determination of myocardial infarction. Both typical and unusual findings are demonstrated with the aid of numerous high-quality color illustrations, and other key literature in forensic histology and immunohistochemistry is highlighted for each topic.


Recenzijas

The present book represents a decisive contribution to keep this fact in mind. Trainees during residency as well as experienced specialists in legal medicine, whether practitioners or researchers, will find the book very instructive and helpful for their daily business. (Daniel Wittschieber, International Journal of Legal Medicine, Vol 133, 2019)









1 Introduction 1(16)
1.1 Microscopic Examinations and Medical Malpractice Cases
7(4)
1.2 Tissue Damage Due to Iatrogenic Interventions
11(2)
1.2.1 Silicone Implant Leakage
11(1)
1.2.2 Iatrogenic Fistulas
11(1)
1.2.3 Decubitus Ulcers
12(1)
References
13(4)
2 Staining Techniques and Microscopy 17(30)
2.1 Conventional Histological Staining
17(5)
2.1.1 Background Staining and Artifacts in Conventional Staining Methods
21(1)
2.2 Immunohistochemical Techniques
22(8)
2.2.1 Methods of Antigen Demasking
25(1)
2.2.2 ABC Method
26(1)
2.2.3 APAAP Method
26(1)
2.2.4 Background Staining and Artifacts in Immunohistochemical Staining
27(3)
2.3 Selection of Antigens and Antibodies
30(3)
2.4 Special Examination Techniques
33(3)
2.4.1 TUNEL Assay
33(2)
2.4.2 In Situ Hybridization
35(1)
2.4.3 Confocal Laser Scanning Microscopy
35(1)
2.4.4 Electron Microscopy
35(1)
2.4.5 Laser Microdissection
36(1)
2.5 Tissue Sample Selection
36(1)
2.6 Interpreting Histological and Immunohistochemical Staining
37(1)
2.7 Selecting a Suitable Positive Control
38(1)
2.8 Immunohistochemical Qualification and Quantification of Individual Cell Types
39(1)
2.9 Histopathological Studies: Findings and Comparability
40(2)
References
42(5)
3 Histopathology of Selected Trauma 47(38)
3.1 Hemorrhage, Necrosis, and Skeletal Muscle Trauma
48(8)
3.1.1 Hemorrhage
48(6)
3.1.2 Necrosis
54(1)
3.1.3 Skeletal Muscle Trauma
54(2)
3.2 Neck Trauma
56(3)
3.3 Cardiac Concussion and Cardiac Contusion
59(1)
3.4 Drowning: Water-Submerged Victims
60(6)
3.4.1 Determining the Postmortem Interval in Water-Submerged Corpses
60(1)
3.4.2 Histology of the Drowned Lung
61(3)
3.4.3 Detection of Diatoms in Death by Drowning
64(2)
3.5 Injury by Firearms and Explosives
66(2)
3.6 Stab Wounds and Hemorrhage
68(4)
3.6.1 Stab Wounds
68(1)
3.6.2 Fatal Hemorrhage with Subendocardial Hemorrhage
69(3)
3.7 Asphyxiation
72(1)
3.8 Differentiation Between SIDS and Asphyxiation
73(1)
3.9 Some Histopathologic Changes due to Cardiopulmonary Resuscitation
74(1)
3.10 Death by Starvation/Dehydration
75(1)
3.11 Traumatic Injury to the Kidneys, Liver, and Pancreas
76(1)
References
77(8)
4 Histopathology and Drug Abuse 85(38)
4.1 Pulmonary Histopathological Findings
86(6)
4.1.1 Pulmonary Edema
86(3)
4.1.2 Pulmonary Granulomatosis (So-Called Junkie Pneumopathy)
89(2)
4.1.3 Pneumonia
91(1)
4.2 Cardiac Histopathological Findings in Intravenous Drug Abuse
92(5)
4.2.1 Myocarditis
92(1)
4.2.2 Cocaine-Induced Findings
93(3)
4.2.3 Endocarditis
96(1)
4.3 Drug-Associated Nephropathies
97(5)
4.3.1 Glomerulonephritis and Glomerulosclerosis
98(4)
4.4 Hepatic Histopathological Findings
102(8)
4.4.1 Hepatitis
102(2)
4.4.2 Peliosis Hepatis
104(1)
4.4.3 Amphetamine-Induced Liver Cell Necroses
104(1)
4.4.4 Ecstasy (MDMA)-Induced Malignant Hyperthermia and Rhabdomyolysis
104(4)
4.4.5 Heroin-Related Rhabdomyolysis
108(2)
4.4.6 Intravenous Injection of Methadone
110(1)
4.4.7 Rachacha Consumption
110(1)
4.5 Neuropathological Findings
110(1)
4.6 Organ Infarction After Drug Consumption
111(1)
4.7 Injection-Related Tissue and Vascular Wall Damage
111(2)
4.8 Necrotizing Myositis and Panniculitis Following Intravenous Drug Injection
113(1)
References
114(9)
5 Toxin- and Drug-Induced Pathologies 123(48)
5.1 Hepatotoxic Histopathological Findings
127(8)
5.1.1 Nonspecific Drug-Induced Hepatitis
128(4)
5.1.2 Hepatic Peliosis and Focal Nodular Hyperplasia
132(2)
5.1.3 Hepatic Lipofuscin
134(1)
5.1.4 Transfusion Siderosis of the Liver
134(1)
5.2 Histopathology of the Cardiotoxic Effects of Selected Medications: Drug-Induced Myocarditis
135(6)
5.3 Histopathology of Other Special Intoxications
141(22)
5.3.1 Special Histopathology in the Case of Colchicine Intoxication
142(2)
5.3.2 Special Histopathology in Cases of Ethylene Glycol Intoxication
144(1)
5.3.3 Lethal Death Cap Intoxication
145(3)
5.3.4 Histopathological Findings in Anabolic Abuse
148(2)
5.3.5 Reye's Syndrome
150(2)
5.3.6 Antibiotic-Induced Pseudomembranous Colitis
152(2)
5.3.7 Acute Drug-Induced Anaphylaxis (Anaphylactic Shock)
154(2)
5.3.8 Anorganic Toxins, Metals, Metalloids, Carbon Monoxide, and Oxygen
156(2)
5.3.9 Intoxication by Medication (Sleep Medications, Analgesics, Anesthetics, Etc.), Organic Poisons, Solvents, Pesticides (Herbicides, Fungicides, Etc.), and Other Selected Poisons
158(3)
5.3.10 Further Fatal Adverse Drug Reactions and Medical Errors
161(2)
5.3.11 Toxin-Induced Histopathological Findings of the Skin
163(1)
References
163(8)
6 Alcohol-Related Histopathology 171(16)
6.1 Alcoholic Liver Pathology
171(5)
6.2 The Pancreas
176(1)
6.3 Alcoholic Cardiomyopathy
176(4)
6.4 Other Alcohol-Associated Histopathological Findings
180(3)
References
183(4)
7 Heat, Fire, Electricity, Lightning, Radiation, and Gases 187(20)
7.1 Heat and Fire
187(7)
7.1.1 The Effects of Heat on the Skin
187(2)
7.1.2 Heat Inhalation Trauma
189(3)
7.1.3 Histological and Immunohistochemical Findings in the Case of Bum Shock
192(2)
7.2 Electricity and Lightning Stroke
194(3)
7.2.1 Electrocution
194(3)
7.2.2 Lightning
197(1)
7.3 Malignant Hyperthermia
197(3)
7.4 Radiation
200(1)
7.5 Selective Internal Radiotherapy (SIRT)
201(1)
7.5.1 Gases
202(1)
References
202(5)
8 Hypothermia 207(8)
References
212(3)
9 Thrombosis and Embolism 215(26)
9.1 Thrombosis
215(5)
9.2 Embolism
220(14)
9.2.1 Thromboembolism
222(1)
9.2.2 Fat and Bone Marrow Embolism
222(6)
9.2.3 Air Embolism
228(1)
9.2.4 Amniotic Fluid Embolism
229(3)
9.2.5 Iatrogenic Embolism
232(1)
9.2.6 Other Embolisms
233(1)
References
234(7)
10 Vitality, Injury Age, Determination of Skin Wound Age, and Fracture Age 241(24)
10.1 Vitality of an Injury or Skin Wound
244(1)
10.2 Wound Age in the Case of Tissue Injuries
245(7)
10.2.1 Invasion of Granulocytes
246(2)
10.2.2 Occurrence of Macrophages
248(1)
10.2.3 Granulation Tissue Formation
249(1)
10.2.4 Inflammation Age in the Case of Fibrinous and Purulent Peritonitis, Pleurisy, and Pericarditis
249(2)
10.2.5 Injury Age of Muscle Trauma
251(1)
10.3 Skin Wounds
252(3)
10.4 Bone Fractures and Fracture Healing
255(3)
References
258(7)
11 Aspiration and Inhalation 265(24)
11.1 Aspiration of Water
266(1)
11.2 Aspiration of Blood
267(3)
11.3 Aspiration of Gastric Content or Chyme
270(2)
11.4 Amniotic Fluid Aspiration
272(2)
11.5 Aspiration of Barium Sulfate
274(1)
11.6 Aspiration of Textile Material and Fibers
274(1)
11.7 Aspiration of Other Substances
275(1)
11.8 Inhalation of Smoke, Dust, Gases, and Allergens
276(8)
11.8.1 Histopathological Findings After Inhalation of Volatile Substances
276(4)
11.8.2 Asthma and Fatal Anaphylaxis
280(2)
11.8.3 Inhalation of Hairspray ("Hairspray Lung")
282(2)
References
284(5)
12 Forensic-Histological Diagnosis of Species, Gender, Age, and Identity 289(14)
12.1 Species Diagnosis
289(1)
12.2 Cytological Gender Determination
290(1)
12.3 Tissue and Organ Determination
291(1)
12.4 ABO Blood Type Verification
292(1)
12.5 Histological Age Estimation
293(1)
12.5.1 Tooth Cementum Annulation for Age Estimation
293(1)
12.5.2 Age Estimation from Human Bones
293(1)
12.5.3 Age Estimation Using Routine Histology
294(1)
12.6 Other Histological Age Determinations
294(3)
12.6.1 Age Determination and the Development of Internal Organs in Embryos and Fetuses
295(1)
12.6.2 Developmental Stages of the Human Placenta in the Embryonic and Fetal Periods
296(1)
12.7 Evidence of Tattoo Remnants in the Identification Process
297(2)
12.8 Xenogeneic Tissue
299(1)
References
299(4)
13 Coronary Sclerosis, Myocardial Infarction, Myocarditis, Cardiomyopathy, Coronary Anomalies, and the Cardiac Conduction System 303(54)
13.1 Sudden Coronary Death
304(5)
13.2 Myocardial Infarction
309(2)
13.3 Acute and Chronic Viral Myocarditis
311(14)
13.3.1 Acute Viral Myocarditis
314(10)
13.3.2 Chronic Myocarditis
324(1)
13.4 Non-virus-Based Myocarditis
325(5)
13.4.1 Bacterial Myocarditis
326(1)
13.4.2 Tuberculous Myocarditis
327(1)
13.4.3 Fungal Myocarditis
327(1)
13.4.4 Rheumatoid Myocarditis
327(1)
13.4.5 Giant-Cell Myocarditis
327(2)
13.4.6 Myocardial Involvement in Sarcoidosis
329(1)
13.4.7 Eosinophilic Myocarditis
329(1)
13.5 Cardiomyopathy
330(7)
13.5.1 Hypertrophic Cardiomyopathy
330(3)
13.5.2 Dilative Cardiomyopathy (DCM)
333(1)
13.5.3 Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVCM)
333(2)
13.5.4 Isolated Noncompaction Cardiomyopathy
335(1)
13.5.5 Alcoholic Cardiomyopathy
335(1)
13.5.6 Rare Forms of Cardiomyopathy
336(1)
13.6 Coronary Anomalies
337(1)
13.7 Cardiac Conduction System (CCS)
338(4)
13.7.1 Examining the CCS
339(1)
13.7.2 Histopathologic Findings in the CCS
339(3)
References
342(15)
14 Vascular, Cardiac Valve, and Metabolic Diseases 357(24)
14.1 Vascular Diseases
357(7)
14.1.1 General, Coronary, and Cerebral Sclerosis
358(1)
14.1.2 Aneurysms
358(1)
14.1.3 Dissecting Aortic Aneurysm in Idiopathic Cystic Medial Necrosis
359(2)
14.1.4 Marfan Syndrome
361(1)
14.1.5 Ehlers-Danlos Syndrome
362(1)
14.1.6 Aneurysms in Other Arteries
363(1)
14.2 Arteritis
364(6)
14.2.1 Syphilitic Mesaortitis
364(1)
14.2.2 Suppurative Aortitis in Atherosclerosis
365(1)
14.2.3 Giant-Cell Arteritis
365(3)
14.2.4 Isolated Coronary Arteritis
368(1)
14.2.5 Takayasu's Arteritis
368(1)
14.2.6 Kawasaki Disease
369(1)
14.2.7 Drug-Associated Vasculitis
370(1)
14.3 Heart Valve Defect: Endocarditis
370(1)
14.4 Amyloidosis
371(3)
14.5 Hemochromatosis
374(1)
14.6 Ochronosis
375(1)
References
375(6)
15 Lethal Infections, Sepsis, and Shock 381(38)
15.1 Pneumonias
382(8)
15.1.1 Purulent Bronchopneumonia
382(1)
15.1.2 Lobar Pneumonia and Carnificating Pneumonia
383(1)
15.1.3 Fungal Pneumonia
384(1)
15.1.4 Pulmonary Tuberculosis
385(2)
15.1.5 Viral Pneumonia
387(2)
15.1.6 Acute Interstitial Pneumonitis (Hamman-Rich Syndrome)
389(1)
15.2 Pancreatitis
390(2)
15.3 Malaria
392(1)
15.4 Clostridia
392(2)
15.5 Measles
394(2)
15.6 Hydatid Disease (Echinococcosis)
396(1)
15.7 Ascending Cholangitis
397(1)
15.8 Ascending Urinary Tract Infections
397(1)
15.9 Glomerulonephritis
398(1)
15.10 OPSI Syndrome
399(2)
15.11 Shock
401(4)
15.12 Iatrogenic Infections
405(2)
15.13 Allergies, Insect Bites, and Anaphylactic Shock
407(3)
15.14 H1N1 Infection
410(2)
15.15 Leptospirosis
412(1)
15.16 Schistosomiasis (Bilharzia)
413(1)
References
414(5)
16 Endocrine Organs 419(22)
16.1 Diabetes
419(4)
16.2 Loss of Adrenocortical Lipids
423(1)
16.3 Acute Primary Adrenal Insufficiency (Addison's Disease)
424(1)
16.4 Fatal Pheochromocytoma
425(1)
16.5 Thyroid and Parathyroid Dysfunction
426(9)
16.5.1 The Thyroid Gland
427(6)
16.5.2 Parathyroid Glands
433(2)
16.6 Pituitary Gland and Hypophyseal Dysfunction
435(1)
References
436(5)
17 Pregnancy-Related Death, Death in Newborns, and Sudden Infant Death Syndrome 441(52)
17.1 Pregnancy-Related Maternal Deaths
441(3)
17.1.1 Extrauterine Pregnancy or Ruptured Tubal/Ectopic Pregnancy
442(1)
17.1.2 HELLP Syndrome
443(1)
17.1.3 Amniotic Fluid Embolism
443(1)
17.1.4 Histology of the "Soap Abortion"
444(1)
17.2 Perinatal Fatalities
444(6)
17.2.1 Death Shortly Before or During Birth
444(4)
17.2.2 Amniotic Infection Syndrome (AIS) and Sepsis Puerperalis
448(2)
17.3 Newborns Found Lifeless
450(2)
17.3.1 Histological Pulmonary Findings
450(1)
17.3.2 Pregnancy Decidua and the Arias-Stella Phenomenon
450(2)
17.4 Sudden Infant Death Syndrome (SIDS)
452(28)
17.4.1 The Respiratory Tract and Lungs
452(9)
17.4.2 Myocarditis and SIDS
461(10)
17.4.3 Cardiomyopathies and SIDS
471(1)
17.4.4 Hypoxia-Related Changes
472(2)
17.4.5 Histopathological Findings in the Cardiac Conduction System
474(1)
17.4.6 Salivary Glands
474(2)
17.4.7 The Liver
476(1)
17.4.8 The Thymus
477(1)
17.4.9 Endocrine Organs (Pancreas, Thyroid, Pituitary)
478(1)
17.4.10 Lymph Nodes and Spleen
479(1)
17.4.11 Additional Histopathological Findings
479(1)
References
480(13)
18 Forensic Cytology 493(10)
18.1 Detection, Isolation, and Species Identification of Cells
493(1)
18.2 Cytological Diagnosis in Sexual Offenses
494(5)
18.2.1 Sperm Detection
495(1)
18.2.2 Detection of Condom Residues
496(2)
18.2.3 Detection of Vaginal Epithelial Cells
498(1)
18.3 Identification of Cells and Tissues in the Case of Suspected Material Contamination or Mix-Up
499(1)
18.4 Transfusion Reactions
499(1)
18.5 Additional Methods of Forensic Cytological Diagnosis
500(1)
References
501(2)
19 Histothanatology: Autolysis, Putrefaction, and Mummification 503(16)
19.1 Time Frame for the Reliable Detection of Microscopic Findings
504(9)
19.2 Microscopic Examination of Stomach Contents
513(2)
References
515(4)
20 Forensic Neuropathology 519(34)
20.1 Forensic Neurotraumatology
519(8)
20.1.1 Intracranial Hematomas or Hemorrhages
520(2)
20.1.2 Wound Age Estimation of Cortical Contusions
522(4)
20.1.3 Apoptosis in Human Traumatic Brain Injury
526(1)
20.1.4 Boxing
526(1)
20.1.5 Agonal Stress and Survival Time
527(1)
20.2 Ischemic and Hypoxic Changes
527(2)
20.3 Meningitis
529(3)
20.3.1 Waterhouse-Friderichsen Syndrome
530(2)
20.3.2 Posttraumatic Meningitis
532(1)
20.4 Unknown Brain Tumors and Malignant Diseases of the Central Nervous System as Cause of Death
532(1)
20.5 Nontraumatic Subarachnoid and Intracerebral Hemorrhages
533(3)
20.5.1 Ruptured Congenital Cerebral Aneurysms Within the Circle of Willis
533(1)
20.5.2 Intracerebral Arteriovenous Malformations
534(2)
20.5.3 Amyloid Angiopathy
536(1)
20.6 Shaken Baby Syndrome (SBS)
536(5)
20.7 Neuropathology of Drug Abuse
541(1)
20.8 Central Pontine Myelinolysis
541(1)
20.9 Fahr Disease
542(1)
20.10 Epilepsy
543(1)
References
544(9)
Index 553
 Professor Reinhard Dettmeyer is Head of the Institute of Forensic Medicine at Justus-Liebig University, Giessen, Germany. Professor Dettmeyer is qualified in both general pathology and forensic pathology, and studied medicine at the University of Düsseldorf and jurisprudence at the Ruhr University, Bochum. Prior to taking up his post in Giessen, he was Senior Physician in the Department of Forensic Medicine at the University of Bonn.

He has written many journal articles on forensic pathology and is co-author of several German language books on child abuse, forensic medicine, and medicolegal issues; in addition, he acted as scientific editor for Volume 2 of the comprehensive Handbuch Gerichtliche Medizin (Handbook of Forensic Medicine). He has also co-authored the book Forensic Medicine Fundamentals and Perspectives, published by Springer in 2014.