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FOXO Transcription Factors: Methods and Protocols 1st ed. 2019 [Hardback]

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  • Formāts: Hardback, 270 pages, height x width: 254x178 mm, weight: 765 g, 33 Illustrations, color; 21 Illustrations, black and white; XII, 270 p. 54 illus., 33 illus. in color., 1 Hardback
  • Sērija : Methods in Molecular Biology 1890
  • Izdošanas datums: 10-Nov-2018
  • Izdevniecība: Humana Press Inc.
  • ISBN-10: 1493988999
  • ISBN-13: 9781493988990
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FOXO Transcription Factors: Methods and Protocols 1st ed. 2019Palielināt
  • Formāts: Hardback, 270 pages, height x width: 254x178 mm, weight: 765 g, 33 Illustrations, color; 21 Illustrations, black and white; XII, 270 p. 54 illus., 33 illus. in color., 1 Hardback
  • Sērija : Methods in Molecular Biology 1890
  • Izdošanas datums: 10-Nov-2018
  • Izdevniecība: Humana Press Inc.
  • ISBN-10: 1493988999
  • ISBN-13: 9781493988990
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9781493988990.html
This volume provides an overview of experimental procedures and state-of art methods to investigate FOXOs. Chapters guide readers through biochemical and molecular methods, imaging approaches to monitor the subcellular localization of FOXO factors, omics and bioinformatics approaches, different animal models used in FOXO research, and human studies to investigate the role of FOXO factors in human disease and longevity. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 Authoritative and cutting-edge FOXO Transcription Factors: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Introduction to FOXO Biology.- Characterization of microRNAs Regulating
FOXO Expression.- Identification of Transcription Factor Binding Sites in the
Mouse FoxO1 Promoter.- Investigating Mechanisms that control
Ubiquitin-mediated DAF-16/FOXO Protein Turnover.- Phosphorylation of FOXO
Proteins as a Key Mechanism to Regulate their Activity.- Methodological
Approach for the Evaluation of FOXO as a Positive Regulator of Antioxidant
Genes.- Characterization of FOXO Acetylation.- Transcriptional Activity of
FoxO Transcription Factors Measured by Luciferase Assays.- Monitoring the
Transcriptional Activity of FOXO Transcription Factors by Analyzing their
Target Genes.- Using ChIP-based Approaches to Characterize FOXO Recruitment
to its Target Promoters.- RNAi Mediated Silencing of FoxO Factors.-
Immunofluorescence Analysis by Confocal Microscopy for Detecting Endogenous
FOXO.- High Throughput Image-based Screening to Identify Chemical Compounds
Capable of Activating FOXO.- Image-based Identification of Chemical Compounds
Capable of   Trapping FOXO in the Cell Nucleus.- Quantifying Tissue-specific
Overexpression of FOXO in Drosophila via mRNA Fluorescence in situ
Hybridization using Branched DNA Probe Technology.- Genome-wide Analysis for
Identifying FOXO Protein Binding Sites.- Mathematical Modeling of Nuclear
Trafficking of  FOXO Transcription Factors.- Following Transcriptome to
Uncover FOXO Biological Functions.- Hydra as Model to Determine the Role of
FoxO in Longevity.- Genetic Ablation of FOXO in Mice to Investigate its
Physiological Role.- Analysis of FOXO3 Gene Polymorphisms Associated with
Human Longevity.- Analysis of FOXO3a Gene Polymorphism Associated with
Asthma.