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E-grāmata: Fusion Genes And Cancer

Edited by (Indian Inst Of Technology Guwahati, India), Edited by (Indian Inst Of Technology Guwahati, India), Edited by (Indian Inst Of Technology Guwahati, India)
  • Formāts: 432 pages
  • Izdošanas datums: 07-Apr-2017
  • Izdevniecība: World Scientific Publishing Co Pte Ltd
  • Valoda: eng
  • ISBN-13: 9789813200951
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Fusion Genes And CancerPalielināt
  • Formāts: 432 pages
  • Izdošanas datums: 07-Apr-2017
  • Izdevniecība: World Scientific Publishing Co Pte Ltd
  • Valoda: eng
  • ISBN-13: 9789813200951
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Development of cancer, a dreadful disease of mankind, is a multi-stage process involving numerous molecular alterations at both genomic and proteomic levels. Immense research for the past several decades in the field of cancer identified many such mutations and their role in carcinogenesis. Concept of 'fusion genes' seeded way back in 20th century has now grown into a new field of cancer research. However, there is a lack of knowledge among scientists about these fusion genes and their importance in cancer, which can be mainly attributed to unavailability of a comprehensive book on this topic. Therefore, this book is first of its kind and aims at giving a detailed idea on the formation of gene fusions and their importance in the development and progression of cancer; techniques to identify novel gene fusions; and therapeutics available to target various fusion proteins and their impact in cancer therapy by compiling the information from the literature available till date.
Preface vii
About the Editors xi
List of Contributors
xiii
1 Cancer --- An Overview and Molecular Alterations in Cancer
1(16)
Nand K. Roy
Devivasha Bordoloi
Javadi Monisha
Anand Anip
Ganesan Padmavathi
Ajaikumar B. Kunnumakkara
2 Basic Concepts of Fusion Genes and Their Classification
17(42)
Ganesan Padmavathi
Nand K. Roy
Devivasha Bordoloi
Javadi Monisha
Ajaikumar B. Kunnumakkara
3 Techniques to Identify Novel Fusion Genes and to Detect Known Fusion Genes
59(22)
Nand K. Roy
Ganesan Padmavathi
Devivasha Bordoloi
Ajaikumar B. Kunnumakkara
4 The Receptor Tyrosine Kinase ALK -- Its Fusion Partners and Their Implication in Various Cancers
81(30)
Ganesan Padmavathi
Krishan Kumar Thakur
Anand Anip
Devivasha Bordoloi
Ajaikumar B. Kunnumakkara
5 Role of BCR-ABL Fusion Kinase in the Development of Leukemia
111(18)
Ganesan Padmavathi
Kishore Banik
Nand K. Roy
Javadi Monisha
Ajaikumar B. Kunnumakkara
6 BRD4-NUT Fusion Oncoprotein and Its Significance in the Initiation and Progression of NUT Midline Carcinoma
129(8)
Ganesan Padmavathi
Devivasha Bordoloi
Kishore Banik
Ajaikumar B. Kunnumakkara
7 Importance of CBFB-MYH11 --- A Chimeric Transcriptional Regulator in Leukemia
137(10)
Ganesan Padmavathi
Choudhary Harsha
Devivasha Bordoloi
Krishan Kumar Thakur
Ajaikumar B. Kunnumakkara
8 Rearrangements Involving ETS Family of Genes and Their Role in Different Cancers
147(16)
Ganesan Padmavathi
Javadi Monisha
Kishore Banik
Choudhary Harsha
Devivasha Bordoloi
Ajaikumar B. Kunnumakkara
9 Translocation of FET Family Members with Various Partner Genes and Their Role in Cancer Development
163(26)
Ganesan Padmavathi
Devivasha Bordoloi
Anand Anip
Krishan Kumar Thakur
Ajaikumar B. Kunnumakkara
10 Translocations of FGF and FGFR Proteins and Their Effect in Cancer
189(12)
Ganesan Padmavathi
Javadi Monisha
Choudhary Harsha
Ajaikumar B. Kunnumakkara
11 IG-MYC and Its Implication in Cancer
201(8)
Ganesan Padmavathi
Kishore Banik
Krishan Kumar Thakur
Ajaikumar B. Kunnumakkara
12 Chimeric RAF Kinases in the Development of Cancer
209(12)
Ganesan Padmavathi
Kishore Banik
Devivasha Bordoloi
Choudhary Harsha
Ajaikumar B. Kunnumakkara
13 Mucoepidermoid Carcinoma (MEC) and Associated MAML2 Fusion Genes
221(10)
Ganesan Padmavathi
Choudhary Harsha
Devivasha Bordoloi
Kishore Banik
Ajaikumar B. Kunnumakkara
14 Mixed Lineage Leukemia/AF9 Fusion and Associated Leukemia
231(14)
Ganesan Padmavathi
Choudhary Harsha
Ajaikumar B. Kunnumakkara
15 MYB-NFIB Fusion Gene --- Hallmark of Adenoid Cystic Carcinoma (ACC)
245(8)
Ganesan Padmavathi
Krishan Kumar Thakur
Ajaikumar B. Kunnumakkara
16 Translocations Involving PAX Family Genes and Their Effect in Cancer
253(18)
Ganesan Padmavathi
Krishan Kumar Thakur
Ajaikumar B. Kunnumakkara
17 Retinoic Acid Receptor Alpha (RARα) Fusion Genes in Leukemia
271(16)
Ganesan Padmavathi
Javadi Monisha
Anand Anip
Krishan Kumar Thakur
Ajaikumar B. Kunnumakkara
18 RET-PTC Translocations and Thyroid Malignancies
287(10)
Ganesan Padmavathi
Devivasha Bordoloi
Anand Anip
Choudhary Harsha
Ajaikumar B. Kunnumakkara
19 RUNX1 or AML1 Fusion Genes in Leukemia and Other Cancers
297(18)
Ganesan Padmavathi
Javadi Monisha
Kishore Banik
Choudhary Harsha
Devivasha Bordoloi
Ajaikumar B. Kunnumakkara
20 Recently Discovered Fusion Genes and Their Implications in Cancer
315(34)
Ganesan Padmavathi
Devivasha Bordoloi
Javadi Monisha
Nand K. Roy
Choudhary Harsha
Ajaikumar B. Kunnumakkara
21 Targeting Fusion Genes for Cancer Therapy
349(24)
Nand K. Roy
Devivasha Bordoloi
Ganesan Padmavathi
Ajaikumar B. Kunnumakkara
Index 373
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