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E-grāmata: Genes, brain, and emotions: Interdisciplinary and Translational Perspectives

Edited by (, Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands), Edited by (, Center of Mental Health, University of W), Edited by (, Cognitive Neuroscience Laboratory, Department of Psychology Babe-Bolyai University, Romania)
  • Formāts: 464 pages
  • Sērija : Series in Affective Science
  • Izdošanas datums: 04-Apr-2019
  • Izdevniecība: Oxford University Press
  • Valoda: eng
  • ISBN-13: 9780192511430
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Genes, brain, and emotions: Interdisciplinary and Translational PerspectivesPalielināt
  • Formāts: 464 pages
  • Sērija : Series in Affective Science
  • Izdošanas datums: 04-Apr-2019
  • Izdevniecība: Oxford University Press
  • Valoda: eng
  • ISBN-13: 9780192511430
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The study of emotions has rapidly expanded in recent decades, incorporating interdisciplinary research on the genetic underpinnings and neural mechanisms of emotion. This has involved a wide range of methods from as varied fields as behavioral genetics, molecular biology, and cognitive neuroscience, and has allowed researchers to start addressing complex multi-level questions such as: what is the role of genes in individual differences in emotions and emotional vulnerability to psychopathology, and what are the neural mechanisms through which genes and experience shape these emotion?

Genes, Brain, and Emotions: Interdisciplinary and translational perspectives offers a comprehensive account of this interdisciplinary field of research, bridging psychology, genetics, and neuroscience, with rich sections dedicated to methods, cognitive and biological mechanisms, and psychopathology. Written by leading researchers who have each inspired new research directions and innovated methods and concepts, this book will be of interest to anyone working or studying in the field of affective science, whether they be behavioural geneticists, psychologists and psychiatrists, or cognitive neuroscientists.
Contributors vii
1 Genes, brain and emotions: Introduction
1(4)
Andrei C. Miu
Judith R. Homberg
Klaus-Peter Lesch
Part 1 Methods and approaches
2 Twin studies of emotion
5(13)
Megan Flom
Kimberly J. Saudino
3 Gene--environment interactions in humans across multiple units of analyses: A focus on psychopathology and imaging
18(14)
Suzanne Vrshek-Schallhorn
Bradley M. Avery
Vaibhav Sapuram
4 Epigenetics and twin studies: A review and applications in human aggressive behavior
32(19)
Jenny van Dongen
Dorret I. Boomsma
5 Genome-wide association studies
51(12)
Thomas W. Muhleisen
Sven Cichon
6 Gene--environment interactions in animal models of depression and anxiety
63(14)
Daniela Felice
Anand Gururajan
Olivia F. O'Leary
John F. Cryan
7 Methods and theoretical approaches: Genetic animal models of emotional disorders and convergence with human data
77(20)
Celine L. St Pierre
Kayvon Sharif
Emily Funsten
Abraham A. Palmer
Clarissa C. Parker
8 Optogenetic and chemogenetic technologies for advanced functional investigations of the neural correlates of emotions
97(16)
Alexandre Surget
Catherine Belzung
Part 2 Cognitive mechanisms
9 Fear learning and extinction
113(16)
Tina B. Lonsdorf
10 Emotional action control: The role of serotonin in health and disease
129(15)
Inge Volman
Hanneke Den Ouden
Karin Roelofs
11 Genetics of emotion regulation: A systematic review
144(26)
Andrei C. Miu
Mirela I. Bile
12 Emotional memory
170(18)
Mana R. Ehlers
Rebecca M. Todd
13 Genetics of decision-making
188(17)
Joshua C. Gray
Sandra Sanchez-Roige
Abraham A. Palmer
Harriet de Wit
James MacKillop
Part 3 Biological mechanisms
14 Missing heritability in studies of trait anxiety and amygdala function: Is the solution in plain sight?
205(11)
Turhan Canli
15 Electrocortical endophenotypes of anxiety
216(19)
Erik M. Mueller
16 Imaging genetics in depression
235(12)
Ulrich Rabl
Lukas Pezawas
17 Psychosocial stress and telomere regulation
247(15)
Idan Shalev
Waylon J. Hastings
18 Genetic effects on peripheral psychophysiological measures of emotion processing
262(13)
Annette Conzelmann
Paul Pauli
Alexander Prehn-Kristensen
Tobias Renner
Part 4 Disorders and therapy
19 The genetics of personality/psychopathology: A brief review of constructs, results, approaches, and implications
275(11)
Thomas J. Bouchard Jr
Wendy Johnson
Irving I. Gottesman
20 Resilience
286(18)
Rebecca Alexander
Justine Megan Gatt
21 Understanding risk and resilience in maltreated children: Emerging findings from translational, genetic, neuroimaging, and treatment studies
304(20)
Joan Kaufman
Janitza L. Montalvo-Ortiz
Richard S. Lee
22 Animal models of post-traumatic stress disorder: Towards understanding of individual differences
324(19)
Lisa Heltzel
Judith R. Homberg
23 Genetics of impulsivity, anger, and aggression as risk factors for suicidal behavior
343(23)
Dan Rujescu
Ina Giegling
24 Causes of distress-induced emotional eating
366(14)
Tatjana van Strien
25 Genetics of obsessive-compulsive disorder and Tourette's syndrome
380(16)
Nuno R. Zilhdo
Dorret I. Boomsma
Dirk J.A. Smit
Danielle C. Cath
26 Therapygenetics: Predicting psychological treatment response from genetic markers
396(25)
Jonathan R.I. Coleman
Kathryn J. Lester
Thalia C. Eley
27 The role of pharmacogenetics in the treatment of depression
421(12)
Airiss R. Chan
Ilona Gorbovskaya
Daniel J. Muller
Index 433
Andrei C. Miu is Professor of Cognitive Neuroscience and Behavioral Genetics at the Department of Psychology, Babe-Bolyai University, and the Founding Director of the Cognitive Neuroscience Laboratory, one of the leading research groups in the field of cognitive and affective science in Romania. His research investigates the psychological and biological mechanisms of emotion and emotion regulation, with the aim of uncovering individual differences that contribute to risk for psychopathology.

Dr. Judith Homberg obtained her PhD in 2004 at the Free University Medical Center in Amsterdam on preclinical research aiming to understand individual differences in vulnerability to drug addiction. Then she pursued a postdoc position at the Hubrecht Institute in Utrecht and generated and characterized knockout rats. One of the knockout rats involved the serotonin transporter knockout rat, which displays heightened emotional behaviour. After obtaining a personal subsidy from the Dutch government she started her own research group at the Donders Institute in Nijmegen in 2008. From this position she further built up her current research group focussing on the individual differences in behaviour and risk for stress-related disorders, with serotonin as main modulator.

Dr. Lesch has undergone training in Psychiatry and Psychotherapy. His work has been focussing on the interdependent relationship between molecular, cellular and systems neurobiology and mechanisms of pharmacologic and psychotherapeutic treatments related to neurodevelopmental and life-spanning psychiatric disorders using interdisciplinary and translational research strategies. In its scope, the Lesch lab's work is regarded as an interface with contributions to bridging the sizeable gap between basic molecular, neurobiologic and clinically applicable research. The work uncompromisingly integrates pertinent research strategies to elucidate mechanisms of pathologically altered synaptic plasticity (synaptopathy), intraneuronal signaling (neuronal dysregulation) and interneuronal communication (system dysfunction) as well as their impact on the pathophysiology of neuropsychiatric disease.
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