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Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology [Hardback]

3.93/5 (1262 ratings by Goodreads)
  • Formāts: Hardback, 368 pages, height x width x depth: 243x162x35 mm, weight: 580 g
  • Izdošanas datums: 15-Feb-2022
  • Izdevniecība: PublicAffairs,U.S.
  • ISBN-10: 1541797914
  • ISBN-13: 9781541797918
  • Hardback
  • Cena: 35,21 €
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  • Formāts: Hardback, 368 pages, height x width x depth: 243x162x35 mm, weight: 580 g
  • Izdošanas datums: 15-Feb-2022
  • Izdevniecība: PublicAffairs,U.S.
  • ISBN-10: 1541797914
  • ISBN-13: 9781541797918
"Synthetic biology is the promising and controversial technology platform that combines biology and artificial intelligence, opening up the potential to program biological systems much as we program computers. Synthetic biology enables us not just to read and edit DNA - the technique of CRISPR - but also write it. Rather than life being "a beautiful game of chance", synthetic biology creates the potential to control our genetic destiny, to say "no" to bad genes and build a veritable genetic app store fordownloading and adding new capabilities into any cell, microbe, plant, or animal. Amy Webb and Andrew Hessel's riveting stories include: the work of scientists to develop plants that can be grown in sprawling indoor farms capable of feeding millions witha fraction of the usual resources required; a synthetic, self-regulating insulin that doesn't require injections or a pump; life-altering regenerative, personalized medicine; and novel, durable solutions to climate change. There is also whimsy, such as the dream of some geneticists to "unextinct" the wooly mammoth. By examining both the science and the ethical, moral, and religious issues surrounding synthetic biology, Webb and Hessel provide the background for preventing its misuse by some to re-engineer their bodies and that of their children, further increasing the disturbing division and polarization of societies into the haves (the enhanced) and the have nots. They provide the background for making wise decisions about issues such as: whether to program novel viruses to fight diseases, what genetic privacy will look like, who will "own" living organisms, how companies should earn revenue from engineered cells, and how to contain a synthetic organism in a lab. Whether we approve or disapprove of synthetic biology, it is coming. Now, we need to understand its promise and peril. Webb and Hessel help us understand the science as well as the political and societal issues involved"--

By examining both the science and the ethic, moral and religious issues surrounding synthetic biology, the authors discuss its potential for helping solve humanity’s existential challenges. 30,000 first printing.

The next frontier in technology is inside our own bodies.

Synthetic biology will revolutionize how we define family, how we identify disease and treat aging, where we make our homes, and how we nourish ourselves. This fast-growing field—which uses computers to modify or rewrite genetic code—has created revolutionary, groundbreaking solutions such as the mRNA COVID vaccines, IVF, and lab-grown hamburger that tastes like the real thing.  It gives us options to deal with existential threats: climate change, food insecurity, and access to fuel.

But there are significant risks.

Who should decide how to engineer living organisms? Whether engineered organisms should be planted, farmed, and released into the wild? Should there be limits to human enhancements? What cyber-biological risks are looming? Could a future biological war, using engineered organisms, cause a mass extinction event? 

Amy Webb and Andrew Hessel’s riveting examination of synthetic biology and the bioeconomy provide the background for thinking through the upcoming risks and moral dilemmas posed by redesigning life, as well as the vast opportunities waiting for us on the horizon.

Introduction: Should Life Be a Game of Chance? 1(12)
PART ONE Origin
1 Saying No to Bad Genes: The Birth of the Genesis Machine
13(16)
2 A Race to the Starting Line
29(18)
3 The Bricks of Life
47(20)
4 God, a Church, and a (Mostly) Woolly Mammoth
67(22)
PART TWO NOW
5 The Bioeconomy
89(20)
6 The Biological Age
109(28)
7 Nine Risks
137(34)
8 The Story of Golden Rice
171(20)
PART THREE Futures
9 Exploring the Recently Plausible
191(8)
10 Scenario One: Creating Your Child with Wellspring
199(6)
11 Scenario Two: What Happened When We Canceled Aging
205(10)
12 Scenario Three: Akira Gold's "Where to Eat" 2037
215(10)
13 Scenario Four: The Underground
225(12)
14 Scenario Five: The Memo
237(10)
PART FOUR The Way Forward
15 A New Beginning
247(30)
Epilogue 277(2)
Acknowledgments 279(6)
Notes 285(36)
Bibliography 321(18)
Index 339
Amy Webb is the founder of the Future Today Institute, a leading foresight and strategy firm that advises CEOs of the world's most-admired companies, three-star admirals and generals, and the senior leadership of central banks and intergovernmental organizations. She is a professor of strategic foresight at New York University's Stern School of Business and a Visiting Fellow at Oxford University's Said School of Business. She was elected a life member of the Council on Foreign Relations, is a member of the Bretton Woods Committee and serves as a Steward and Steering Committee member of the World Economic Forum. Amy was named by Forbes as "one of the five women changing the world" and was honored as one of the BBC's 100 Women of 2020. Amy is author of The Big Nine: How the Tech Titans and Their Thinking Machines Could Warp Humanity and The Signals are Talking: Why Today's Fringe is Tomorrow's Mainstream. She resides in Baltimore, MD.





Andrew Hessel, a pioneer and an expert in the field of synthetic biology, is the president of Humane Genomics, an early-stage company developing synthetic viruses for canine and human oncology. He is also the co-founder and chairman of the Center of Excellence for Engineering Biology and the Genome Project, the international scientific effort to engineer large genomes, including the human genome. He is a former distinguished research scientist at Autodesk Life Sciences.