About the Editors |
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xi | |
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xiii | |
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1 | (2) |
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2 Evolutionary Computation: A Brief Overview |
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3 | (14) |
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3 | (1) |
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2.2 Evolutionary Computation Paradigms |
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4 | (8) |
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5 | (2) |
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2.2.2 Evolution Strategies |
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7 | (1) |
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2.2.3 Evolutionary Programming |
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8 | (1) |
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2.2.4 Genetic Programming |
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8 | (2) |
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2.2.5 Other Evolutionary Techniques |
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10 | (1) |
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2.2.6 Theory of Evolutionary Algorithms |
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11 | (1) |
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12 | (5) |
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3 A Review of Medical Applications of Genetic and Evolutionary Computation |
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17 | (28) |
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3.1 Medical Imaging and Signal Processing |
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18 | (7) |
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18 | (1) |
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18 | (3) |
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3.1.3 Image Registration, Reconstruction and Correction |
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21 | (3) |
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24 | (1) |
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3.2 Data Mining Medical Data and Patient Records |
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25 | (2) |
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3.3 Clinical Expert Systems and Knowledge-based Systems |
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27 | (2) |
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3.4 Modelling and Simulation of Medical Processes |
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29 | (5) |
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3.5 Clinical Diagnosis and Therapy |
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34 | (11) |
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4 Applications of GEC in Medical Imaging |
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45 | (66) |
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4.1 Evolutionary Deformable Models for Medical Image Segmentation: A Genetic Algorithm Approach to Optimizing Learned, Intuitive, and Localized Medial-based Shape Deformation |
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47 | (22) |
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47 | (7) |
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4.1.1.1 Statistically Constrained Localized and Intuitive Deformations |
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54 | (3) |
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4.1.1.2 Genetic Algorithms |
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57 | (1) |
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58 | (1) |
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4.1.2.1 Population Representation |
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58 | (1) |
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4.1.2.2 Encoding the Weights for GAs |
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58 | (1) |
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4.1.2.3 Mutations and Crossovers |
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59 | (1) |
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4.1.2.4 Calculating the Fitness of Members of the GA Population |
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60 | (2) |
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62 | (1) |
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63 | (6) |
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4.2 Feature Selection for the Classification of Microcalcifications in Digital Mammograms using Genetic Algorithms, Sequential Search and Class Separability |
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69 | (16) |
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Santiago E. Conant-Pablos |
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Rolando R. Hernandez-Cisneros |
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69 | (2) |
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71 | (1) |
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71 | (1) |
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4.2.2.2 Detection of Potential Microcalcifications (Signals) |
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72 | (2) |
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4.2.2.3 Classification of Signals into Microcalcifications |
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74 | (2) |
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4.2.2.4 Detection of Microcalcification Clusters |
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76 | (1) |
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4.2.2.5 Classification of Microcalcification Clusters into Benign and Malignant |
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77 | (1) |
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4.2.3 Experiments and Results |
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77 | (1) |
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4.2.3.1 From Pre-processing to Signal Extraction |
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77 | (2) |
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4.2.3.2 Classification of Signals into Microcalcifications |
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79 | (2) |
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4.2.3.3 Microcalcification Clusters Detection and Classification |
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81 | (1) |
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4.2.4 Conclusions and Future Work |
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82 | (3) |
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4.3 Hybrid Detection of Features within the Retinal Fundus using a Genetic Algorithm |
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85 | (26) |
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85 | (3) |
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4.3.2 Acquisition and Processing of Retinal Fundus Images |
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88 | (1) |
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4.3.2.1 Retinal Image Acquisition |
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89 | (1) |
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90 | (1) |
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91 | (2) |
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93 | (1) |
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4.3.4.1 Vasculature Extraction |
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94 | (5) |
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4.3.4.2 A Genetic Algorithm for Edge Extraction |
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99 | (4) |
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4.3.4.3 Skeletonization Process |
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103 | (1) |
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4.3.4.4 Experimental Results |
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104 | (7) |
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5 New Analysis of Medical Data Sets using GEC |
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111 | (62) |
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5.1 Analysis and Classification of Mammography Reports using Maximum Variation Sampling |
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113 | (20) |
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113 | (1) |
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114 | (2) |
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116 | (2) |
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5.1.4 Maximum Variation Sampling |
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118 | (4) |
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122 | (2) |
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124 | (1) |
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5.1.7 Results & Discussion |
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124 | (5) |
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129 | (4) |
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5.2 An Interactive Search for Rules in Medical Data using Multiobjective Evolutionary Algorithms |
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133 | (16) |
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5.2.1 Medical Data Mining |
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133 | (1) |
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5.2.2 Measures for Evaluating the Rules Quality |
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134 | (1) |
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5.2.2.1 Accuracy Measures |
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135 | (1) |
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5.2.2.2 Comprehensibility Measures |
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135 | (1) |
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5.2.2.3 Interestingness Measures |
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136 | (1) |
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5.2.3 Evolutionary Approaches in Rules Mining |
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137 | (1) |
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5.2.4 An Interactive Multiobjective Evolutionary Algorithm for Rules Mining |
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138 | (1) |
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139 | (1) |
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5.2.4.2 Reproduction Operators |
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139 | (1) |
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5.2.4.3 Selection and Archiving |
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140 | (1) |
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5.2.4.4 User Guided Evolutionary Search |
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141 | (2) |
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5.2.5 Experiments in Medical Rules Mining |
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143 | (1) |
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5.2.5.1 Impact of User Interaction |
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144 | (2) |
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146 | (3) |
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5.3 Genetic Programming for Exploring Medical Data using Visual Spaces |
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149 | (24) |
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149 | (1) |
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150 | (1) |
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5.3.2.1 Visual Space Realization |
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150 | (1) |
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5.3.2.2 Visual Space Taxonomy |
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150 | (1) |
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5.3.2.3 Visual Space Geometries |
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151 | (1) |
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5.3.2.4 Visual Space Interpretation Taxonomy |
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151 | (2) |
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5.3.2.5 Visual Space Characteristics Examination |
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153 | (1) |
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5.3.2.6 Visual Space Mapping Taxonomy |
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154 | (1) |
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5.3.2.7 Visual Space Mapping Computation |
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155 | (2) |
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5.3.3 Experimental Settings |
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157 | (1) |
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5.3.3.1 Implicit Classical Algorithm Settings |
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158 | (1) |
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5.3.3.2 Explicit GEP Algorithm Settings |
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159 | (2) |
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161 | (1) |
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5.3.4.1 Data Space Examples |
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161 | (3) |
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5.3.4.2 Semantic Space Examples |
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164 | (6) |
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170 | (3) |
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6 Advanced Modelling, Diagnosis and Treatment using GEC |
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173 | (50) |
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6.1 Objective Assessment of Visuo-spatial Ability using Implicit Context Representation Cartesian Genetic Programming |
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175 | (16) |
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175 | (1) |
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6.1.2 Evaluation of Visuo-spatial Ability |
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176 | (2) |
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6.1.3 Implicit Context Representation CGP |
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178 | (2) |
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180 | (1) |
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181 | (1) |
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181 | (1) |
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6.1.4.3 Parameter Settings |
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182 | (2) |
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184 | (2) |
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186 | (5) |
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6.2 Towards an Alternative to Magnetic Resonance Imaging for Vocal Tract Shape Measurement using the Principles of Evolution |
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191 | (18) |
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191 | (3) |
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6.2.2 Oral Tract Shape Evolution |
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194 | (1) |
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6.2.3 Recording the Target Vowels |
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195 | (1) |
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6.2.4 Evolving Oral Tract Shapes |
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196 | (3) |
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199 | (1) |
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200 | (1) |
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6.2.5.2 Spectral Comparisons |
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201 | (3) |
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204 | (5) |
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6.3 How Genetic Algorithms can Improve Pacemaker Efficiency |
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209 | (14) |
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209 | (2) |
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6.3.2 Modeling of the Electrical Activity of the Heart |
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211 | (2) |
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6.3.3 The Optimization Principles |
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213 | (1) |
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6.3.3.1 The Cost Function |
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213 | (1) |
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6.3.3.2 The Optimization Algorithm |
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213 | (1) |
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6.3.3.3 A New Genetic Algorithm with a Surrogate Model |
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214 | (1) |
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6.3.3.4 Results of AGA on Test Functions |
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215 | (1) |
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6.3.4 A Simplified Test Case for a Pacemaker Optimization |
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216 | (1) |
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6.3.4.1 Description of the Test Case |
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216 | (2) |
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6.3.4.2 Numerical Results |
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218 | (2) |
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220 | (3) |
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7 The Future for Genetic and Evolutionary Computation in Medicine: Opportunities, Challenges and Rewards |
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223 | (6) |
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224 | (1) |
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224 | (2) |
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226 | (1) |
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7.4 The Future for Genetic and Evolutionary Computation in Medicine |
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227 | (2) |
Appendix: Introductory Books and Useful Links |
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229 | (2) |
Index |
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231 | |