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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine [Mīkstie vāki]

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(Professor, Center for Molecular Medicine and Genetics, Pathology Department, Wayne State University School of Medicine, Wayne State University, Detroit, MI, USA)
  • Formāts: Paperback / softback, 556 pages, height x width: 229x152 mm, weight: 880 g
  • Izdošanas datums: 29-May-2019
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0128136359
  • ISBN-13: 9780128136355
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  • Cena: 156,15 €
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Genome Chaos: Rethinking Genetics, Evolution, and Molecular MedicinePalielināt
  • Formāts: Paperback / softback, 556 pages, height x width: 229x152 mm, weight: 880 g
  • Izdošanas datums: 29-May-2019
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0128136359
  • ISBN-13: 9780128136355
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780128136355.html
Keywords:

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.

  • Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine
  • Gathers the most pressing questions in genomic and cytogenomic research
  • Offers alternative explanations to timely puzzles in the field
  • Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more
Preface ix
Acknowledgments xiii
1 From Mendelian Genetics to 4D Genomics
1.1 Summary
1(1)
1.2 The Emergence of Genomics
2(13)
1.3 Diminishing Power of Gene-Based Genomics
15(22)
1.4 New Genomic Science on the Horizon
37(16)
2 Genes and Genomes Represent Different Biological Entities
2.1 Summary
53(1)
2.2 The Definition of the Genome
53(4)
2.3 "Parts Versus the Whole": The Emergent Relationship (Which Challenges Reductionism)
57(3)
2.4 ReExamining Gene Theory Predictions
60(23)
2.5 The Conflicting Relationship Between the Gene and the Genome
83(9)
2.6 Genome Context Determines Gene Function
92(1)
2.7 Action Needed
93(2)
3 Genome Chaos and Macrocellular Evolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer
3.1 Summary
95(1)
3.2 SOS: We Need a New Conceptual Framework for Cancer Research
96(38)
3.3 Genome Chaos: Rediscovery of the Importance of the Karyotype in Cancer
134(27)
3.4 A New Genomic Model for Cancer Evolution
161(8)
4 Chromosomal Coding and Fuzzy Inheritance: The Genomic Basis of Bio-information and Heterogeneity
4.1 Summary
169(1)
4.2 Chromosomal or Karyotype Coding
170(32)
4.3 Fuzzy Inheritance
202(40)
4.4 Overlooked Genome Variations
242(19)
5 Why Sex? Genome Reinterpretation Dethrones the Queen
5.1 Summary
261(1)
5.2 What Is the Purpose of Sex? The Answer Is Not Obvious
262(5)
5.3 Surprise! Asexual Reproduction Does Not Generate Clonal Progenitors!
267(6)
5.4 The Search for the Main Function and Common Mechanism of Sex
273(4)
5.5 The Battle Is On: Changing Concepts
277(9)
5.6 Simulation: Ask the Simplest Question About the Function of Sex
286(3)
5.7 Case Studies: Reinterpretation Using New Framework
289(3)
5.8 Lessons Learned
292(7)
6 Breaking the Genome Constraint: The Mechanism of Macroevolution
6.1 Summary
299(1)
6.2 Pattern of Cellular Evolution Challenges Current Evolutionary Theory
300(16)
6.3 Artificial Selection and Natural Selection Are Fundamentally Different
316(7)
6.4 Both Isolated Cases and Isolated Natural Environments Represent Exceptions That Fail to Demonstrate the Relationship Between Micro- and Macroevolution
323(9)
6.5 Maintaining Genome Integrity: The Major Evolutionary Constraint
332(6)
6.6 Implications of Genome Theory to Evolutionary Concepts
338(20)
6.7 Evolution Is True but Its Mechanism Must Be Reexamined
358(23)
6.8 Implications: Creating Artificial Species by Shattering the Genome Followed by Artificial Mating/Genome Selection
381(2)
7 The Genome Theory: A New Framework
7.1 Summary
383(1)
7.2 The Rationale for Establishing a Genome-Based Genomic Theory
383(4)
7.3 Unique Considerations for Genome Theory
387(5)
7.4 Outline of the Genome Theory
392(21)
7.5 The Predictions, Implications, Limitations, and Falsifiability of the Genome Theory
413(8)
7.6 Challenges Ahead
421(6)
8 The Rationale and Challenges of Molecular Medicine
8.1 Summary
427(1)
8.2 A Brief History: The Promises of Molecular Medicine
427(3)
8.3 The Challenges and Opportunities for Precision Medicine
430(28)
8.4 Future Direction
458(23)
Epilogue (or Why We Did What We Did) 481(8)
Bibliography 489(46)
Index 535
Dr. Henry H. Heng has coauthored over 200 publications and serves on the editorial boards of seven international, peer-reviewed journals. Using single-cell analysis of in vitro and in vivo models, Dr. Hengs group has illustrated the evolutionary dynamics of cancer progression by directly observing evolution in action. Such experiments revealed that cancer evolution involves two phases: punctuated genome alteration-mediated macroevolution (which creates a new system), followed by stepwise gene and epigenetic-mediated microevolution (which leads to population growth). By applying this concept to organismal evolution, he discovered that the main function of sex is to reduce genetic diversity at the genome level in order to preserve genome-defined species identity information. Heng introduced the Genome Architecture Theory, a new genome-based conceptual framework of genomics and evolution.