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E-grāmata: Geometric Induction of Bone Formation [Taylor & Francis e-book]

(University of the Witwatersrand, Bone Research Lab, Johannesburg, South Africa)
  • Formāts: 228 pages, 93 Illustrations, color
  • Izdošanas datums: 24-Dec-2020
  • Izdevniecība: CRC Press
  • ISBN-13: 9780429203299
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  • Taylor & Francis e-book
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Geometric Induction of Bone FormationPalielināt
  • Formāts: 228 pages, 93 Illustrations, color
  • Izdošanas datums: 24-Dec-2020
  • Izdevniecība: CRC Press
  • ISBN-13: 9780429203299
Citas grāmatas par šo tēmu:
Taylor & Francis e-booksMore info about Taylor & Francis e-books
Rokasgrāmatas mājas lapa: https://www.taylorfrancis.com/books/9780429203299
The Geometric Induction of Bone Formation describes new biomimetic biomaterials that offer mechanistic osteogenic surfaces for the autonomous and spontaneous induction of bone formation without the addition of osteogenic soluble molecular signals of the transforming growth factor- supergene family. The chapters frame our understanding of regenerative medicine in primate species, including humans. The goal is to unravel the fundamental biological mechanisms of bone formation unique to non-human and human primates. The broad target audience dovetails with several disciplines both in the academic and private biotech sectors primarily involved in molecular biology, tissue biology, tissue engineering, biomaterial science, and reconstructive, orthopedic, plastic, and dental surgery.

Key Features











Includes outstanding images of undecalcified whole mounted sections





Summarizes non-human primate research ideal for clinical translation





Reviews methods for creating devices capable of making bone autonomously, i.e. an intrinsically osteo-inductive bioreactor and/or biomaterial





Describes the spontaneous induction of bone formation including a whole spectrum of tissue biology, from basic molecular biology to clear-cut morphology and pre-clinical application in non-human primate species





Intended for audiences in both academic research and the biotech industry
Acknowledgements xi
Author xiii
List of Contributors
xv
Introduction xvii
Chapter 1 The New Frontiers in Bone Tissue Engineering: Functionalized Biomimetic Surfaces beyond Morphogens and Stem Cells
1(24)
Ugo Ripamonti
Laura C. Roden
1.1 Tissue Induction and Morphogenesis
1(11)
1.2 The Concavity: The Shape of Life
12(13)
Acknowledgements
19(1)
References
20(5)
Chapter 2 The Induction of Bone Formation: When and Why Bone Forms and Sometimes Repairs and Regenerates: The Enigmatic Myth of Bone Tissue Engineering and the Dream of Regenerative Medicine
25(26)
Ugo Ripamonti
2.1 The Induction of Bone Formation
25(7)
2.2 Molecular Redundancy and the Induction of Bone Formation by the Human Transforming Growth Factor-β3
32(4)
2.3 Translational Research on the Recombinant Transforming Growth Factor-β3 in Human Patients
36(2)
2.4 Molecular Microenvironments Super Activated by Morphogenetic Signals
38(2)
2.5 Diffusible Signals, Microenvironments and the Establishment of Morphogenetic Gradients
40(11)
References
45(6)
Chapter 3 The Induction of Bone Formation and the Osteogenic Proteins of the Transforming Growth Factor-β Supergene Family: Pleiotropism and Redundancy
51(18)
Ugo Ripamonti
3.1 Why Bone?
51(10)
3.2 Morphogens and the Induction of Bone Formation
61(1)
3.3 The Osteogenic Proteins of the Transforming Growth Factor-β Supergene Family
62(7)
References
65(4)
Chapter 4 Coral-Derived Hydroxyapatite-Based Macroporous Bioreactors Initiate the Spontaneous Induction of Bone Formation in Heterotopic Extraskeletal Sites: Morphological Time Studies
69(40)
Ugo Ripamonti
4.1 Self-Inducing Osteoinductive Biomimetic Matrices
69(8)
4.2 Tissue Induction and Morphogenesis by Coral-Derived Hydroxyapatite Constructs on Day 15 after Heterotopic Rectus Abdominis Implantation
77(15)
4.3 Tissue Induction and Morphogenesis by Coral-Derived Hydroxyapatite Constructs on Days 60 and 90 after Heterotopic Rectus Abdominis Implantation
92(5)
4.4 Angiogenesis, Capillary Sprouting and the Induction of Bone Formation
97(12)
Acknowledgements
103(1)
References
104(5)
Chapter 5 Concavities of Crystalline Sintered Hydroxyapatite-Based Macroporous Bioreactors Initiate the Spontaneous Induction of Bone Formation
109(50)
Ugo Ripamonti
5.1 Introduction
109(1)
5.2 Self-Inductive Biomaterials
110(3)
5.3 Surface Geometry Regulates Bone Differentiation in Heterotopic Sites
113(17)
5.4 The Geometric Design of the Concavity Regulates the Induction of Bone Formation
130(3)
5.5 The Concavity: The Shape of Life - Perspective and Limitations
133(8)
5.6 Chondrogenesis in Biomimetic Calcium Phosphate-Based Bioreactors
141(18)
Acknowledgements
146(1)
Bibliography
147(12)
Chapter 6 Molecular Pathways Regulating the Geometric Induction of Bone Formation: Synthetizing and Embedding Osteogenic Proteins into Nanotopographic Geometries
159(22)
Raquel Duarte
Ugo Ripamonti
6.1 Introduction
159(2)
6.2 Tissue Patterning of Geometric Constructs: Morphological and Molecular Observations
161(10)
6.3 Mechanistic Insights into the Induction of Bone Formation by 7% HA/CC Macroporous Bioreactors
171(6)
6.4 Conclusion
177(4)
References
178(3)
Chapter 7 The Spontaneous Induction of Bone Formation by Intrinsically Osteoinductive Bioreactors for Human Patients: Osteoinductive Hydroxyapatite-Coated Titanium Implants
181(42)
Ugo Ripamonti
7.1 Geometry and the Rationale for Fabricating Self-Inducing Osteoinductive Hydroxyapatite-Coated Titanium Implants
181(4)
7.2 Solid Titanium Bioreactors with the Concavity Motif
185(9)
7.3 Does Pure Titanium Metal per se Initiate the Spontaneous Induction of Bone Formation?
194(10)
7.4 The Geometric Induction of Bone Formation
204(6)
7.5 Inducive Morphogenetic Gradients of the Concavity
210(13)
References
215(8)
Index 223
Ugo Ripamonti is a leader in the field of tissue induction and differentiation in postnatal osteogenesis. His principal achievement is the demonstration of the induction of bone formation in non-human primate models. In 1994 he was appointed professor at the Medical School University of the Witwatersrand, Johannesburg, in South Africa, leading its newly founded Bone Research Laboratory. He has written more than 200 publications, given more than 120 invited lectures at international symposia, and organized a series of workshops and symposia at the World Biomaterials Congresses and the International Conferences on Bone Morphogenetic Proteins.
Permanent link: https://www.kriso.lv/db/9780429203299_pe.html
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