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Goldfrank's Toxicologic Emergencies, Ninth Edition 9th edition [Hardback]

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  • Formāts: Hardback, 1968 pages, height x width x depth: 285x224x71 mm, weight: 4217 g, 500 Illustrations
  • Izdošanas datums: 16-Sep-2010
  • Izdevniecība: McGraw-Hill Medical
  • ISBN-10: 0071605932
  • ISBN-13: 9780071605939
Citas grāmatas par šo tēmu:
  • Formāts: Hardback, 1968 pages, height x width x depth: 285x224x71 mm, weight: 4217 g, 500 Illustrations
  • Izdošanas datums: 16-Sep-2010
  • Izdevniecība: McGraw-Hill Medical
  • ISBN-10: 0071605932
  • ISBN-13: 9780071605939
Citas grāmatas par šo tēmu:
Goldfranks Toxicological Emergencies is a multi-authored text of more than 2000 pages prepared by utilizing the education and management principles we apply at the New York City Poison Center and at our clinical sites. In this ninth edition of Goldfranks Toxicological Emergencies, we proudly offer readers an approach to medical toxicology using evidence based principles viewed through a lens of bedside clinical practice--Provided by publisher. Goldfranks Toxicologic Emergencies continues to be the source you can turn to first for any poisoning or overdose. The text provides clear information on every aspect of toxicologic emergencies, from pharmacology to clinical presentation to management.Fully referenced and featuring a consistent organization, Goldfranks begins with an in-depth examination of general principles of medical toxicology. It the progresses to the biochemical principles and molecular basis of toxicology, and provides detailed insight into how xenobiotics affect vital signs, organs, and systems throughout the body. Next, a wide spectrum of clinically important exposures -- including drugs, plants, metals, household products, and occupational and environmental xenobiotics are covered within logical categories for easy access to information. Finally, the book concludes with sections on principles for practicing clinical toxicology in todays challenging healthcare environment. The book Doody’s called “the definitive reference in the field” is now in full color!Goldfrank’s Toxicologic Emergencies is known worldwide as the most comprehensive and authoritative reference available on the management of poisoned and overdosed patients. This trusted classic covers all toxic substances –- including drugs, plants, household and industrial chemicals, and heavy metals. The eighth edition is both an outstanding educational resource and a valuable clinical companion. Much of the educational material is now available on the new online learning center, and more clinically-relevant figures and tables have been added to the book. Market: Emergency Physicians (40,000), Medical Toxicologists (2,000), Emergency Departments (5,000), Poison Centers (50)New Full-color presentationNew Online learning center with cases, Q&A, and imagesLewis S. Nelson, M.D, F.A.C.E.P., F.A.C.M.T. Neal A. Lewin, M.D., F.A.C.P., F.A.C.E.P., F.A.C.M.T. Mary Ann Howland, Pharm.D., D.A.B.A.T., F.A.A.C.T. Robert S. Hoffman, M.D., F.A.A.C.T., F.A.C.M.T. Lewis R. Goldfrank, M.D., F.A.C.E.P., F.A.A.E.M., F.A.A.C.T., F.A.C.M.T., F.A.C.P. (New York, NY) are affiliated with Bellevue Hospital Center, New York University School of Medicine, New York University Medical Center. Neal E. Flomenbaum, M.D., F.A.C.P., F.A.C.E.P. (New York, NY) New York Presbyterian Hospital, Weill Medical College, Cornell University.
Contributors xv
Preface xxvii
Acknowledgments xxviii
1 Historical Principles and Perspectives
1(17)
Paul M. Wax
2 Toxicologic Plagues and Disasters in History
18(13)
Paul M. Wax
PART A THE GENERAL APPROACH TO MEDICAL TOXICOLOGY
31(124)
3 Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes
33(4)
Lewis S. Nelson
Neal A. Lewin
Mary Ann Howland
Robert S. Hoffman
Lewis R. Goldfrank
Neal E. Flomenbaum
4 Principles of Managing the Acutely Poisoned or Overdosed Patient
37(8)
Lewis S. Nelson
Neal A. Lewin
Mary Ann Howland
Robert S. Hoffman
Lewis R. Goldfrank
Neal E. Flomenbaum
5 Diagnostic Imaging
45(25)
David T. Schwartz
6 Laboratory Principles
70(20)
Petrie M. Rainey
7 Techniques Used to Prevent Gastrointestinal Absorption
90(29)
Anne-Bolette Gude
Lotte C. G. Hoegberg
A1 Syrup of Ipecac
104(4)
Mary Ann Howland
A2 Activated Charcoal
108(6)
Mary Ann Howland
A3 Whole-Bowel Irrigation and Other Intestinal Evacuants
114(5)
Mary Ann Howland
8 Pharmacokinetic and Toxicokinetic Principles
119(16)
Mary Ann Howland
9 Principles and Techniques Applied to Enhance Elimination
135(13)
David S. Goldfarb
10 Use of The Intensive Care Unit
148(7)
Mark A. Kirk
PART B THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY
155(2)
SECTION 1 Biochemical and Molecular Basis
157(71)
11 Chemical Principles
157(13)
Stephen J. Traub
Lewis S. Nelson
12 Biochemical and Metabolic Principles
170(19)
Kurt C. Kleinschmidt
Kathleen A. Delaney
13 Neurotransmitters and Neuromodulators
189(32)
Steven C. Curry
Kirk Charles Mills
Anne-Michelle Ruha
Ayrn D. O'Connor
14 Withdrawal Principles
221(7)
Richard J. Hamilton
SECTION 2 Pathophysiologic Basis: Organ Systems
228(195)
15 Thermoregulatory Principles
228(21)
Susi U. Vassallo
Kathleen A. Delaney
16 Fluid, Electrolyte, and Acid-Base Principles
249(16)
Alan N. Charney
Robert S. Hoffman
17 Psychiatric Principles
265(10)
Kishor Malavade
Mark R. Serper
18 Neurologic Principles
275(10)
Rama B. Rao
19 Ophthalmic Principles
285(7)
Adhi Sharma
20 Otolaryngologic Principles
292(11)
William K. Chiang
21 Respiratory Principles
303(11)
Andrew Stolbach
Robert S. Hoffman
22 Electrophysiologic and Electrocardiographic Principles
314(16)
Cathleen Clancy
23 Hemodynamic Principles
330(10)
Robert A. Hessler
24 Hematologic Principles
340(19)
Marco L. A. Sivilotti
25 Gastrointestinal Principles
359(8)
Richard G. Church
Kavita M. Babu
26 Hepatic Principles
367(14)
Kathleen A. Delaney
27 Renal Principles
381(15)
Donald A. Feinfeld
Nikolas B. Harbord
28 Genitourinary Principles
396(14)
Jason Chu
29 Dermatologic Principles
410(13)
Neal A. Lewin
Lewis S. Nelson
SECTION 3 Special Populations
423(58)
30 Reproductive and Perinatal Principles
423(24)
Jeffrey S. Fine
31 Pediatric Principles
447(14)
Jeffrey S. Fine
32 Geriatric Principles
461(10)
Judith C. Ahronheim
Mary Ann Howland
33 Postmortem Toxicology
471(10)
Rama B. Rao
Mark A. Flomenbaum
SC1 Organ Procurement from Poisoned Patients
479(2)
Rama B. Rao
PART C THE CLINICAL BASIS OF MEDICAL TOXICOLOGY
481(2)
SECTION 1
A Analgesics and Antiinflammatory Medications
483(1)
34 Acetaminophen
483(25)
Robert G. Hendrickson
A4 N-Acetylcysteine
500(8)
Mary Ann Howland
Robert G. Hendrickson
35 Salicylates
508(20)
Neal E. Flomenbaum
A5 Sodium Bicarbonate
520(8)
Paul M. Wax
36 Nonsteroidal Antiinflammatory Drugs
528(9)
William J. Holubek
37 Colchicine, Podophyllin, and the Vinca Alkaloids
537(22)
Joshua G. Schier
SC2 Intrathecal Administration of Xenobiotics
548(11)
Rama B. Rao
38 Opioids
559(27)
Lewis S. Nelson
Dean Olsen
A6 Opioid Antagonists
579(7)
Mary Ann Howland
Lewis S. Nelson
B Foods, Dietary and Nutritional Xenobiotics
586(1)
39 Dieting Agents and Regimens
586(10)
Jeanna M. Marraffa
40 Iron
596(13)
Jeanmarie Perrone
A7 Deferoxamine
604(5)
Mary Ann Howland
41 Vitamins
609(15)
Beth Y. Ginsburg
42 Essential Oils
624(7)
Sarah Eliza Halcomb
43 Herbal Preparations
631(23)
Oliver L. Hung
44 Athletic Performance Enhancers
654(14)
Susi U. Vassallo
45 Food Poisoning
668(14)
Michael G. Tunik
46 Botulism
682(16)
Howard L. Geyer
A8 Botulinum Antitoxin
695(3)
Lewis R. Goldfrank
Howard L. Geyer
C Pharmaceuticals
698(1)
47 Anticonvulsants
698(16)
Suzanne Doyon
A9 L-Carnitine
711(3)
Mary Ann Howland
48 Antidiabetics and Hypoglycemics
714(24)
George M. Bosse
A10 Dextrose
728(6)
Larissa I. Velez
Kathleen A. Delaney
A11 Octreotide
734(4)
Mary Ann Howland
49 Thyroid and Antithyroid Medications
738(10)
Nicole C. Bouchard
50 Antihistamines and Decongestants
748(15)
Anthony J. Tomassoni
Richard S. Weisman
A12 Physostigmine Salicylate
759(4)
Mary Ann Howland
51 Antimigraine Medications
763(7)
Jason Chu
52 Antineoplastics Overview
770(8)
Richard Y. Wang
53 Antineoplastics: Methotrexate
778(18)
Richard Y. Wang
A13 Leucovorin (Folinic Acid) and Folic Acid
783(4)
Mary Ann Howland
A14 Glucarpidase (Carboxypeptidase G2)
787(6)
Silas W. Smith
SC3 Extravasation of Xenobiotics
793(3)
Richard Y. Wang
54 Miscellaneous Antineoplastics
796(7)
Richard Y. Wang
55 Pharmaceutical Additives
803(14)
Sean P. Nordt
Lisa E. Vivero
D Antimicrobials
817(1)
56 Antibacterials, Antifungals, and Antivirals
817(17)
Christine M. Stork
57 Antituberculous Medications
834(15)
Christina H. Hernon
Edward W. Boyer
A15 Pyridoxine
845(4)
Mary Ann Howland
58 Antimalarials
849(12)
J. Dave Barry
E Cardiopulmonary Medications
861(1)
59 Anticoagulants
861(23)
Mark Su
A16 Vitamin K1
876(4)
Mary Ann Howland
A17 Protamine
880(4)
Mary Ann Howland
60 Calcium Channel Blockers
884(12)
Francis Jerome DeRoos
A18 Insulin-Euglycemia Therapy
893(3)
William Kerns
61 β-Adrenergic Antagonists
896(18)
Jeffrey R. Brubacher
A19 Glucagon
910(4)
Mary Ann Howland
62 Other Antihypertensives
914(11)
Francis Jerome DeRoos
63 Antidysrhythmics
925(11)
Lewis S. Nelson
Neal A. Lewin
64 Cardioactive Steroids
936(16)
Jason B. Hack
A20 Digoxin-Specific Antibody Fragments
946(6)
Mary Ann Howland
65 Methylxanthines and Selective β2 Adrenergic Agonists
952(13)
Robert J. Hoffman
F Anesthetics and Related Medications
965(1)
66 Local Anesthetics
965(17)
David R. Schwartz
Brian Kaufman
A21 Intravenous Fat Emulsions
976(6)
Theodore C. Bania
67 Inhalational Anesthetics
982(7)
Brian Kaufman
Martin Griffel
68 Neuromuscular Blockers
989(14)
Kenneth M. Sutin
A22 Dantrolene Sodium
1001(2)
Kenneth M. Sutin
G Psychotropic Medications
1003(1)
69 Antipsychotics
1003(13)
David N. Juurlink
70 Lithium
1016(11)
Howard A. Greller
71 Monoamine Oxidase Inhibitors
1027(10)
Alex F. Manini
72 Serotonin Reuptake Inhibitors and Atypical Antidepressants
1037(12)
Christine M. Stork
73 Cyclic Antidepressants
1049(11)
Erica L. Liebelt
74 Sedative-Hypnotics
1060(18)
David C. Lee
Kathy Lynn Ferguson
A23 Flumazenil
1072(6)
Mary Ann Howland
H Substances of Abuse
1078(1)
75 Amphetamines
1078(13)
William K. Chiang
76 Cocaine
1091(24)
Jane M. Prosser
Robert S. Hoffman
SC4 Internal Concealment of Xenobiotics
1103(6)
Jane M. Prosser
A24 Benzodiazepines
1109(6)
Robert S. Hoffman
Lewis S. Nelson
Mary Ann Howland
77 Ethanol
1115(19)
Luke Yip
A25 Thiamine Hydrochloride
1129(5)
Robert S. Hoffman
78 Ethanol Withdrawal
1134(9)
Jeffrey A. Gold
Lewis S. Nelson
79 Disulfiram and Disulfiram-Like Reactions
1143(8)
Edwin K. Kuffner
80 γ-Hydroxybutyric Acid
1151(6)
Brenna M. Farmer
81 Inhalants
1157(9)
Heather Long
82 Hallucinogens
1166(11)
Kavita M. Babu
83 Cannabinoids
1177(8)
Michael A. McGuigan
84 Nicotine
1185(6)
Sari Soghoian
85 Phencyclidine and Ketamine
1191(11)
Ruben E. Olmedo
86 Aluminum
1202(5)
Brenna M. Farmer
I Metals
1207(1)
87 Antimony
1207(7)
Asim F. Tarabar
88 Arsenic
1214(19)
Stephen W. Munday
Marsha D. Ford
A26 Dimercaprol (British Anti-Lewisite or BAL)
1229(4)
Mary Ann Howland
89 Bismuth
1233(4)
Rama B. Rao
90 Cadmium
1237(6)
Stephen J. Traub
Robert S. Hoffman
91 Chromium
1243(5)
Steven B. Bird
92 Cobalt
1248(8)
Gar Ming Chan
93 Copper
1256(10)
Lewis S. Nelson
94 Lead
1266(28)
Fred M. Henretig
A27 Succimer (2, 3-Dimercaptosuccinic Acid)
1284(6)
Mary Ann Howland
A28 Edetate Calcium Disodium (CaNa2 EDTA)
1290(4)
Mary Ann Howland
95 Manganese
1294(5)
Sari Soghoian
96 Mercury
1299(9)
Young-Jin Sue
97 Nickel
1308(8)
John A. Curtis
David A. Haggerty
98 Selenium
1316(5)
Diane P. Calello
99 Silver
1321(5)
Melisa W. Lai Becker
Michele Burns Ewald
100 Thallium
1326(13)
Maria Mercurio-Zappala
Robert S. Hoffman
A29 Prussian Blue
1334(5)
Robert S. Hoffman
101 Zinc
1339(6)
Nima Majlesi
J Household Products
1345(1)
102 Antiseptics, Disinfectants, and Sterilants
1345(13)
Paul M. Wax
103 Camphor and Moth Repellents
1358(6)
Edwin K. Kuffner
104 Caustics
1364(10)
Jessica A. Fulton
105 Hydrofluoric Acid and Fluorides
1374(12)
Mark Su
A30 Calcium
1381(5)
Mary Ann Howland
106 Hydrocarbons
1386(14)
David D. Gummin
107 Toxic Alcohols
1400(23)
Sage W. Wiener
SC5 Diethylene Glycol
1411(3)
Joshua G. Schier
A31 Fomepizole
1414(5)
Mary Ann Howland
A32 Ethanol
1419(4)
Mary Ann Howland
K Pesticides
1423(1)
108 Pesticides: An Overview of Rodenticides and a Focus on Principles
1423(11)
Neal E. Flomenbaum
109 Barium
1434(3)
Andrew Dawson
110 Sodium Monofluoroacetate and Fluoroacetamide
1437(3)
Fermin Barrueto
111 Phosphorus
1440(5)
Michael C. Beuhler
112 Strychnine
1445(5)
Yiu-Cheung Chan
113 Insecticides: Organic Phosphorus Compounds and Carbamates
1450(27)
Michael Eddleston
Richard Franklin Clark
A33 Pralidoxime
1467(6)
Mary Ann Howland
A34 Atropine
1473(4)
Mary Ann Howland
114 Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellents
1477(17)
Michael G. Holland
115 Herbicides
1494(22)
Darren M. Roberts
116 Methyl Bromide and Other Fumigants
1516(6)
Keith K. Burkhart
L Natural Toxins and Envenomations
1522(1)
117 Muschrooms
1522(15)
Lewis R. Goldfrank
118 Plants
1537(24)
Mary Emery Palmer
Joseph M. Betz
119 Arthropods
1561(26)
In-Hei Hahn
A35 Antivenom (Scorpion and Spider)
1582(5)
Richard Franklin Clark
120 Marine Envenomations
1587(14)
D. Eric Brush
121 Snakes and Other Reptiles
1601(14)
Bradley D. Riley
Anthony F. Pizon
Anne-Michelle Ruha
A36 Antivenom (Crotaline)
1611(4)
Anthony F. Pizon
Bradley D. Riley
Anne-Michelle Ruha
M Occupational and Environmental Toxins
1615(1)
122 Industrial Poisoning: Information and Control
1615(10)
Peter H. Wald
123 Nanotoxicology
1625(18)
Silas W. Smith
124 Simple Asphyxiants and Pulmonary Irritants
1643(15)
Lewis S. Nelson
Oladapo A. Odujebe
125 Carbon Monoxide
1658(20)
Christian Tomaszewski
A37 Hyperbaric Oxygen
1671(7)
Stephen R. Thom
126 Cyanide and Hydrogen Sulfide
1678(20)
Christopher P. Holstege
Gary E. Isom
Mark A. Kirk
A38 Sodium and Amyl Nitrite
1689(3)
Mary Ann Howland
A39 Sodium Thiosulfate
1692(3)
Mary Ann Howland
A40 Hydroxocobalamin
1695(3)
Mary Ann Howland
127 Methemoglobin Inducers
1698(13)
Dennis P. Price
A41 Methylene Blue
1708(3)
Mary Ann Howland
128 Smoke Inhalation
1711(10)
Nathan Phillip Charlton
Mark A. Kirk
N Disaster Preparedness
1721(1)
129 Risk Assessment and Risk Communication
1721(6)
Charles A. McKay
130 Hazmat Incident Response
1727(8)
Bradley J. Kaufman
131 Chemical Weapons
1735(15)
Jeffrey R. Suchard
132 Biological Weapons
1750(9)
Jeffrey R. Suchard
133 Radiation
1759(23)
Joseph G. Rella
A42 Potassium Iodide
1775(4)
Joseph G. Rella
A43 DTPA [ Pentetic Acid or Pentetate (Zinc or Calcium) Trisodium]
1779(3)
Joseph G. Rella
SECTION 2 Poison Centers and Epidemiology
1782(57)
134 Poison Prevention and Education
1782(7)
Lauren Schwartz
135 Poison Centers and Poison Epidemiology
1789(7)
Robert S. Hoffman
136 International Perspectives on Medical Toxicology
1796(7)
Michael Eddleston
137 Principles of Epidemiology and Research Design
1803(8)
Kevin C. Osterhoudt
138 Adverse Drug Events and Postmarketing Surveillance
1811(9)
Louis R. Cantilena Jr
139 Medication Safety and Adverse Drug Events
1820(11)
Brenna M. Farmer
140 Risk Management and Legal Principles
1831(8)
Barbara M. Kirrane
Dainius A. Drukteinis
Index 1839
Lewis S. Nelson, MD, FACEP, FACMT Director, Medical Toxicology Fellowship Program; Associate Director, New York City Poison Center; Attending Physician, Department of Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Assistant Professor of Emergency Medicine, New York University School of Medicine, New York, New York.





Neal A. Lewin, MD, FACP, FACEP, FACMT Director, Didactic Education, Attending Physician, Department of Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Clinical Associate Professor of Emergency Medicine and Medicine (Clinical Pharmacology), New York University School of Medicine; Consultant, New York City Poison Center, New York, New York.





Mary Ann Howland, PharmD, DABAT, FAACT Clinical Professor of Pharmacy, St. Johns University College of Pharmacy; Consultant, Department of Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Senior Consultant in Residence, New York City Poison Center, New York, New York.





Robert S. Hoffman, MD, FAACT, FACMT Director, New York City Poison Center; Attending Physician, Department of Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Associate Professor, Emergency Medicine and Medicine (Clinical Pharmacology), New York University School of Medicine, New York, New York.





Lewis R. Goldfrank, MD, FACEP, FAAEM, FAACT, FACMT, FACP Professor and Chair, Department of Emergency Medicine, New York University School of Medicine; Director, Emergency Medicine, Bellevue Hospital Center and New York University Medical Center; Medical Director, New York City Poison Center, New York, New York.





Neal E. Flomenbaum, MD, FACP, FACEP Emergency Physician-in-Chief, New York Presbyterian Hospital; Professor of Clinical Medicine, Weill Medical College, Cornell University; Consultant, New York City Poison Center, New York, New York.