Contributors |
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xv | |
Preface |
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xxvii | |
Acknowledgments |
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xxviii | |
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1 Historical Principles and Perspectives |
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1 | (17) |
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2 Toxicologic Plagues and Disasters in History |
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18 | (13) |
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PART A THE GENERAL APPROACH TO MEDICAL TOXICOLOGY |
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31 | (124) |
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3 Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes |
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33 | (4) |
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4 Principles of Managing the Acutely Poisoned or Overdosed Patient |
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37 | (8) |
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45 | (25) |
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70 | (20) |
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7 Techniques Used to Prevent Gastrointestinal Absorption |
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90 | (29) |
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104 | (4) |
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108 | (6) |
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A3 Whole-Bowel Irrigation and Other Intestinal Evacuants |
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114 | (5) |
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8 Pharmacokinetic and Toxicokinetic Principles |
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119 | (16) |
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9 Principles and Techniques Applied to Enhance Elimination |
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135 | (13) |
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10 Use of The Intensive Care Unit |
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148 | (7) |
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PART B THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY |
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155 | (2) |
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SECTION 1 Biochemical and Molecular Basis |
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157 | (71) |
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157 | (13) |
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12 Biochemical and Metabolic Principles |
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170 | (19) |
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13 Neurotransmitters and Neuromodulators |
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189 | (32) |
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221 | (7) |
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SECTION 2 Pathophysiologic Basis: Organ Systems |
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228 | (195) |
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15 Thermoregulatory Principles |
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228 | (21) |
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16 Fluid, Electrolyte, and Acid-Base Principles |
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249 | (16) |
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17 Psychiatric Principles |
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265 | (10) |
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275 | (10) |
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285 | (7) |
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20 Otolaryngologic Principles |
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292 | (11) |
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21 Respiratory Principles |
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303 | (11) |
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22 Electrophysiologic and Electrocardiographic Principles |
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314 | (16) |
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23 Hemodynamic Principles |
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330 | (10) |
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24 Hematologic Principles |
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340 | (19) |
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25 Gastrointestinal Principles |
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359 | (8) |
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367 | (14) |
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381 | (15) |
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28 Genitourinary Principles |
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396 | (14) |
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29 Dermatologic Principles |
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410 | (13) |
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SECTION 3 Special Populations |
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423 | (58) |
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30 Reproductive and Perinatal Principles |
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423 | (24) |
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447 | (14) |
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461 | (10) |
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471 | (10) |
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SC1 Organ Procurement from Poisoned Patients |
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479 | (2) |
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PART C THE CLINICAL BASIS OF MEDICAL TOXICOLOGY |
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481 | (2) |
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A Analgesics and Antiinflammatory Medications |
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483 | (1) |
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483 | (25) |
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500 | (8) |
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508 | (20) |
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520 | (8) |
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36 Nonsteroidal Antiinflammatory Drugs |
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528 | (9) |
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37 Colchicine, Podophyllin, and the Vinca Alkaloids |
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537 | (22) |
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SC2 Intrathecal Administration of Xenobiotics |
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548 | (11) |
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559 | (27) |
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579 | (7) |
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B Foods, Dietary and Nutritional Xenobiotics |
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586 | (1) |
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39 Dieting Agents and Regimens |
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586 | (10) |
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596 | (13) |
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604 | (5) |
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609 | (15) |
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624 | (7) |
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631 | (23) |
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44 Athletic Performance Enhancers |
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654 | (14) |
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668 | (14) |
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682 | (16) |
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695 | (3) |
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698 | (1) |
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698 | (16) |
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711 | (3) |
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48 Antidiabetics and Hypoglycemics |
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714 | (24) |
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728 | (6) |
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734 | (4) |
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49 Thyroid and Antithyroid Medications |
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738 | (10) |
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50 Antihistamines and Decongestants |
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748 | (15) |
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A12 Physostigmine Salicylate |
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759 | (4) |
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51 Antimigraine Medications |
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763 | (7) |
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52 Antineoplastics Overview |
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770 | (8) |
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53 Antineoplastics: Methotrexate |
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778 | (18) |
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A13 Leucovorin (Folinic Acid) and Folic Acid |
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783 | (4) |
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A14 Glucarpidase (Carboxypeptidase G2) |
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787 | (6) |
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SC3 Extravasation of Xenobiotics |
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793 | (3) |
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54 Miscellaneous Antineoplastics |
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796 | (7) |
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55 Pharmaceutical Additives |
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803 | (14) |
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817 | (1) |
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56 Antibacterials, Antifungals, and Antivirals |
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817 | (17) |
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57 Antituberculous Medications |
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834 | (15) |
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845 | (4) |
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849 | (12) |
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E Cardiopulmonary Medications |
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861 | (1) |
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861 | (23) |
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876 | (4) |
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880 | (4) |
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60 Calcium Channel Blockers |
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884 | (12) |
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A18 Insulin-Euglycemia Therapy |
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893 | (3) |
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61 β-Adrenergic Antagonists |
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896 | (18) |
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910 | (4) |
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62 Other Antihypertensives |
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914 | (11) |
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925 | (11) |
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936 | (16) |
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A20 Digoxin-Specific Antibody Fragments |
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946 | (6) |
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65 Methylxanthines and Selective β2 Adrenergic Agonists |
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952 | (13) |
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F Anesthetics and Related Medications |
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965 | (1) |
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965 | (17) |
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A21 Intravenous Fat Emulsions |
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976 | (6) |
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67 Inhalational Anesthetics |
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982 | (7) |
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68 Neuromuscular Blockers |
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989 | (14) |
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1001 | (2) |
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G Psychotropic Medications |
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1003 | (1) |
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1003 | (13) |
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1016 | (11) |
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71 Monoamine Oxidase Inhibitors |
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1027 | (10) |
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72 Serotonin Reuptake Inhibitors and Atypical Antidepressants |
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1037 | (12) |
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73 Cyclic Antidepressants |
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1049 | (11) |
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1060 | (18) |
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1072 | (6) |
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1078 | (1) |
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1078 | (13) |
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1091 | (24) |
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SC4 Internal Concealment of Xenobiotics |
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1103 | (6) |
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1109 | (6) |
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1115 | (19) |
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A25 Thiamine Hydrochloride |
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1129 | (5) |
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1134 | (9) |
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79 Disulfiram and Disulfiram-Like Reactions |
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1143 | (8) |
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1151 | (6) |
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1157 | (9) |
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1166 | (11) |
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1177 | (8) |
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1185 | (6) |
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85 Phencyclidine and Ketamine |
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1191 | (11) |
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1202 | (5) |
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1207 | (1) |
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1207 | (7) |
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1214 | (19) |
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A26 Dimercaprol (British Anti-Lewisite or BAL) |
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1229 | (4) |
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1233 | (4) |
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1237 | (6) |
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1243 | (5) |
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1248 | (8) |
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1256 | (10) |
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1266 | (28) |
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A27 Succimer (2, 3-Dimercaptosuccinic Acid) |
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1284 | (6) |
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A28 Edetate Calcium Disodium (CaNa2 EDTA) |
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1290 | (4) |
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1294 | (5) |
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1299 | (9) |
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1308 | (8) |
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1316 | (5) |
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1321 | (5) |
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1326 | (13) |
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1334 | (5) |
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1339 | (6) |
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1345 | (1) |
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102 Antiseptics, Disinfectants, and Sterilants |
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1345 | (13) |
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103 Camphor and Moth Repellents |
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1358 | (6) |
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1364 | (10) |
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105 Hydrofluoric Acid and Fluorides |
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1374 | (12) |
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1381 | (5) |
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1386 | (14) |
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1400 | (23) |
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1411 | (3) |
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1414 | (5) |
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1419 | (4) |
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1423 | (1) |
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108 Pesticides: An Overview of Rodenticides and a Focus on Principles |
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1423 | (11) |
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1434 | (3) |
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110 Sodium Monofluoroacetate and Fluoroacetamide |
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1437 | (3) |
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1440 | (5) |
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1445 | (5) |
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113 Insecticides: Organic Phosphorus Compounds and Carbamates |
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1450 | (27) |
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1467 | (6) |
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1473 | (4) |
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114 Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellents |
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1477 | (17) |
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1494 | (22) |
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116 Methyl Bromide and Other Fumigants |
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1516 | (6) |
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L Natural Toxins and Envenomations |
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1522 | (1) |
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1522 | (15) |
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1537 | (24) |
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1561 | (26) |
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A35 Antivenom (Scorpion and Spider) |
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1582 | (5) |
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1587 | (14) |
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121 Snakes and Other Reptiles |
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1601 | (14) |
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A36 Antivenom (Crotaline) |
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1611 | (4) |
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M Occupational and Environmental Toxins |
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1615 | (1) |
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122 Industrial Poisoning: Information and Control |
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1615 | (10) |
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1625 | (18) |
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124 Simple Asphyxiants and Pulmonary Irritants |
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1643 | (15) |
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1658 | (20) |
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1671 | (7) |
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126 Cyanide and Hydrogen Sulfide |
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1678 | (20) |
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A38 Sodium and Amyl Nitrite |
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1689 | (3) |
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1692 | (3) |
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1695 | (3) |
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127 Methemoglobin Inducers |
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1698 | (13) |
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1708 | (3) |
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1711 | (10) |
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1721 | (1) |
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129 Risk Assessment and Risk Communication |
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1721 | (6) |
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130 Hazmat Incident Response |
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1727 | (8) |
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1735 | (15) |
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1750 | (9) |
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1759 | (23) |
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1775 | (4) |
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A43 DTPA [ Pentetic Acid or Pentetate (Zinc or Calcium) Trisodium] |
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1779 | (3) |
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SECTION 2 Poison Centers and Epidemiology |
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1782 | (57) |
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134 Poison Prevention and Education |
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1782 | (7) |
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135 Poison Centers and Poison Epidemiology |
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1789 | (7) |
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136 International Perspectives on Medical Toxicology |
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1796 | (7) |
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137 Principles of Epidemiology and Research Design |
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1803 | (8) |
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138 Adverse Drug Events and Postmarketing Surveillance |
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1811 | (9) |
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139 Medication Safety and Adverse Drug Events |
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1820 | (11) |
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140 Risk Management and Legal Principles |
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1831 | (8) |
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Index |
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1839 | |