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E-grāmata: Guidance for the Description of Animal Research in Scientific Publications

  • Formāts: 42 pages
  • Izdošanas datums: 16-Sep-2011
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309219549
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  • Formāts: 42 pages
  • Izdošanas datums: 16-Sep-2011
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309219549
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The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results.





Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.





Table of Contents



Front Matter Guidance for the Description ofAnimal Research in Scientific Publications Appendix Animal Research: Reporting In Vivo Experiments: The ARRIVE Guidelines
1 Overview
1(3)
1.1 The Need for Guidance
2(1)
1.2 Related Guidelines
3(1)
1.3 Organization and Content of This Report
3(1)
2 Defining an Optimal Description of an Animal Study
4(1)
2.1 How Much Detail Is Necessary?
4(1)
2.2 A Values-Based Approach
5(1)
3 The Research Animal
5(3)
3.1 General
5(1)
3.2 Source
6(1)
3.3 Genetics
6(1)
3.4 Microbial/Pathogen Status
7(1)
3.5 Preparation and Assignment of the Research Animal to Study
8(1)
4 The Research Animal Environment (Study Conditions)
8(3)
4.1 Diet
9(1)
4.2 Water
9(1)
4.3 Housing
9(1)
4.4 Macroenvironment
10(1)
5 Basic Animal Methodology
11(1)
5.1 Description of the Research Animal during the Study
11(1)
5.2 Administration of Anesthetics, Analgesics, and Other Substances
11(1)
5.3 Use of Infectious Agents
12(1)
5.4 Tissue and Fluid Sample Acquisition
12(1)
5.5 Euthanasia
12(1)
6 Aquatic Systems
12(2)
6.1 Water Quality
12(1)
6.2 Diet
13(1)
6.3 Housing
13(1)
6.4 Animal Numbers
14(1)
7 Summary and Conclusions
14(1)
References 15(12)
Appendix 27