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E-grāmata: Guide for the Care and Use of Laboratory Animals: Eighth Edition

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  • Formāts: 246 pages
  • Izdošanas datums: 27-Dec-2010
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309186636
  • Formāts - EPUB+DRM
  • Cena: 40,06 €*
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  • Formāts: 246 pages
  • Izdošanas datums: 27-Dec-2010
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309186636

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A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: *Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. *Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. *Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. *Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. *Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
1 Key Concepts
1(10)
Applicability and Goals
2(1)
Intended Audiences and Uses of the Guide
3(1)
Ethics and Animal Use
4(1)
The Three Rs
4(1)
Key Terms Used in the Guide
5(2)
Humane Care
6(1)
Animal Care and Use Program
6(1)
Engineering Performance and Practice Standards
6(1)
Policies, Principles, and Procedures
7(1)
Must Should and May
8(1)
References
8(3)
2 Animal Care and use Program
11(30)
Regulations Policies and Principles
12(1)
Program Management
13(11)
Program Management Responsibility
13(1)
The Institutional Official
13(1)
The Attending Veterinarian
14(1)
The Institutional Animal Care and Use Committee
14(1)
Collaborations
15(1)
Personnel Management
15(1)
Training and Education
15(2)
Occupational Health and Safety of Personnel
17(6)
Personnel Security
23(1)
Investigating and Reporting Animal Welfare Concerns
23(1)
Program Oversight
24(11)
The Role of the IACUC
24(1)
IACUC Constitution and Function
24(1)
Protocol Review
25(2)
Special Considerations for IACUC Review
27(6)
Postapproval Monitoring
33(2)
Disaster Planning and Emergency Preparedness
35(1)
References
35(6)
3 Environment Housing and Management
41(64)
Terrestrial Animals
42(35)
Terrestrial Environment
42(1)
Microenvironment and Macroenvironment
42(1)
Temperature and Humidity
43(2)
Ventilation and Air Quality
45(2)
Illumination
47(2)
Noise and Vibration
49(1)
Terrestrial Housing
50(1)
Microenvironment (Primary Enclosure)
50(2)
Environmental Enrichment
52(2)
Sheltered or Outdoor Housing
54(1)
Naturalistic Environments
55(1)
Space
55(8)
Terrestrial Management
63(1)
Behavioral and Social Management
63(2)
Husbandry
65(10)
Population Management
75(2)
Aquatic Animals
77(11)
Aquatic Environment
77(1)
Microenvironment and Macroenvironment
77(1)
Water Quality
78(1)
Life Support System
79(1)
Temperature Humidity and Ventilation
80(1)
Illumination
81(1)
Noise and Vibration
81(1)
Aquatic Housing
82(1)
Microenvironment (Primary Enclosure)
82(1)
Environmental Enrichment and Social Housing
82(1)
Sheltered Outdoor and Naturalistic Housing
83(1)
Space
83(1)
Aquatic Management
84(1)
Behavior and Social Management
84(1)
Husbandry
84(3)
Population Management
87(1)
References
88(17)
4 Veterinary Care
105(28)
Animal Procurement and Transportation
106(3)
Animal Procurement
106(1)
Transportation of Animals
107(2)
Preventive Medicine
109(4)
Animal Biosecurity
109(1)
Quarantine and Stabilization
110(1)
Separation by Health Status and Species
111(1)
Surveillance Diagnosis Treatment and Control of Disease
112(1)
Clinical Care and Management
113(2)
Medical Management
114(1)
Emergency Care
114(1)
Recordkeeping
115(1)
Surgery
115(5)
Training
115(1)
Presurgical Planning
116(1)
Surgical Facilities
116(1)
Surgical Procedures
117(1)
Aseptic Technique
118(1)
Intraoperative Monitoring
119(1)
Postoperative Care
119(1)
Pain and Distress
120(1)
Anesthesia and Analgesia
121(2)
Euthanasia
123(1)
References
124(9)
5 Physical Plant
133(22)
General Considerations
133(2)
Location
134(1)
Centralization Versus Decentralization
134(1)
Functional Areas
135(1)
Construction Guidelines
136(8)
Corridors
136(1)
Animal Room Doors
137(1)
Exterior Windows
137(1)
Floors
137(1)
Drainage
138(1)
Walls and Ceilings
138(1)
Heating Ventilation and Air Conditioning (HVAC)
139(2)
Power and Lighting
141(1)
Storage Areas
141(1)
Noise Control
142(1)
Vibration Control
142(1)
Facilities for Sanitizing Materials
143(1)
Environmental Monitoring
143(1)
Special Facilities
144(7)
Surgery
144(1)
Barrier Facilities
145(1)
Imaging
146(1)
Whole Body Irradiation
147(1)
Hazardous Agent Containment
148(1)
Behavioral Studies
149(1)
Aquatic Species Housing
150(1)
Security and Access Control
151(1)
References
151(4)
ADDENDUM
155(6)
APPENDICES
A Additional Selected Refferences
161(38)
Subject Matter
161(1)
Use of Laboratory Animals
162(1)
Alternatives
162(1)
Ethics and Welfare
163(1)
Experimental Design and Statistics
164(1)
Research and Testing Methodology
165(2)
Program Management
167(1)
General References
167(1)
Laws Regulations and Policies
168(1)
Education
169(1)
Monitoring the Care and Use of Animals
169(1)
Occupational Health and Safety
170(2)
Environment Housing and Management
172(1)
General References
172(1)
Environmental Enrichment
173(2)
Genetics and Genetically Modified Animals
175(1)
Species-Specific References---Environment Housing, and Management
176(1)
Agricultural Animals
176(2)
Amphibians Reptiles and Fish
178(1)
Birds
179(1)
Cats and Dogs
180(1)
Exotic Wild and Zoo Animals
181(1)
Nonhuman Primates
182(2)
Rodents and Rabbits
184(3)
Other Animals
187(1)
Veterinary Care
188(1)
Transportation
188(1)
Anesthesia, Pain and Surgery
188(2)
Disease Surveillance Diagnosis and Treatment
190(1)
Pathology Clinical Pathology and Parasitology
190(1)
Species-Specific References---Veterinary Care
191(1)
Agricultural Animals
191(1)
Amphibians Reptiles and Fish
192(1)
Birds
193(1)
Cats and Dogs
193(1)
Exotic Wild and Zoo Animals
193(1)
Nonhuman Primates
194(1)
Rodents and Rabbits
194(2)
Design and Construction of Animal Facilities
196(3)
B U.S. Government Principles for the Utilization and Care of Vertebrate Animals used in Testing Research and Training
199(2)
C Statement of Task
201(2)
D About the Authors
203(6)
Index 209