Gut Microbiota: Interactive Effects on Nutrition and Health focuses on the fascinating intestinal microbiome as it relates to nutrition. The book covers the core science in the microbiome field and draws links between the microbiome and nutrition in medicine. Reflecting the most current state of evidence available in the field, the early chapters introduce key concepts about the microbiome, and the latter focus on the application of the gut microbiome and nutrition science. Both human studies and animal studies (where appropriate) are discussed throughout the work.
Addressing topics such as gut microbiota throughout the lifespan, gut microbiota in health and disease, and genetic and environmental influences on gut microbiota, this book will provide scientists and clinicians who have an interest in the microbiome with an understanding of the future potential and limitations of this tool as they strive to make use of evidence-based diet information for the maintenance of good health.
Preface |
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ix | |
Acknowledgments |
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xiii | |
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1 An Overview of the Human Microbiome |
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1 | (16) |
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1 | (1) |
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1 | (4) |
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5 | (2) |
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Characterization of the "Normal" Human Microbiome |
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7 | (8) |
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15 | (2) |
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17 | (24) |
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Bacteria in the Digestive Tract |
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17 | (16) |
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Other Microorganisms in the Digestive Tract |
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33 | (2) |
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35 | (6) |
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3 Gut Microbiota Throughout the Lifespan |
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41 | (16) |
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Changes in Gut Bacterial Communities Over a Lifetime |
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41 | (11) |
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Gut Eukaryotes and Viruses |
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52 | (1) |
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53 | (4) |
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4 Gut Microbiota in Health and Disease |
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57 | (34) |
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Microbial Tolerance and Maintenance of Gut Homeostasis |
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58 | (2) |
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Significant Microbial Enteric Pathogens |
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60 | (5) |
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Complex Diseases Linked to the Gut Microbiota |
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65 | (18) |
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83 | (8) |
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5 Genetic and Environmental Influences on Gut Microbiota |
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91 | (14) |
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91 | (2) |
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93 | (5) |
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98 | (1) |
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99 | (1) |
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100 | (1) |
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101 | (1) |
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101 | (1) |
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102 | (1) |
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102 | (3) |
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6 Impact of Nutrition on the Gut Microbiota |
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105 | (28) |
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Nutrition Modulates the Microbiota |
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106 | (19) |
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Individualized Responses to Diet |
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125 | (1) |
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Dietary Changes in Populations Over Time |
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126 | (1) |
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126 | (1) |
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126 | (7) |
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7 Therapeutic Manipulation of Gut Microbiota |
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133 | (26) |
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134 | (6) |
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Next-Generation Probiotics |
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140 | (1) |
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141 | (4) |
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145 | (1) |
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145 | (1) |
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146 | (1) |
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Fecal Microbiota Transplantation |
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147 | (2) |
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Defined Microbial Consortia |
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149 | (1) |
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Further Methods of Gut Microbiota Manipulation for Therapeutic Benefit |
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150 | (3) |
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153 | (6) |
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8 Practical Diet Recommendations |
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159 | (12) |
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Therapeutic Diets and the Intestinal Microbiota |
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159 | (6) |
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Practical Diet Recommendations to Support a Health-Associated Intestinal Microbiota |
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165 | (3) |
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168 | (3) |
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9 Applications of Gut Microbiota and Nutrition Science |
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171 | (10) |
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Emphasis on Microbes in Food Processing |
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172 | (2) |
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174 | (1) |
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175 | (1) |
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176 | (1) |
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New Tools for Food Safety |
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176 | (2) |
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178 | (3) |
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10 The Future of Gut Microbiota and Nutrition |
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181 | (8) |
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The Future of Gut Microbiome Research |
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182 | (3) |
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185 | (2) |
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187 | (2) |
Index |
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189 | |
Edward Ishiguro is a microbial biochemist and a professor emeritus at the University of Victoria, Canada. His 35-year research career is notable for the discovery of how bacteria in nongrowing or slowgrowing states develop temporary tolerance to antibiotics, a condition known as persistence, which is an important consideration in chemotherapy of infections involving biofilms. A recipient of the UVic Faculty of Science Teaching Excellence Award (2005) and the UVic Alumni Association Harry Hickman Teaching Excellence Award (2006), he currently dedicates much of his time as a science communicator to local schools and various lay audiences. Natasha Haskey is a clinician scientist and a registered dietitian in Canada with more than 20 years of clinical experience. Fascinated by all things microbiome, Natasha completed her PhD at the University of British Columbia, focusing on how diet influences inflammation and the gut microbiome. She is passionate about translating emerging scientific information about nutrition and the microbiome for healthcare professionals. Kristina Campbell is a science and medical writer who specializes in creating resources for healthcare professionals on the emerging translational aspects of the gut microbiome, probiotics, and prebiotics. She covers microbiome science for online and print media throughout Europe and North America and is also the author of The Well-Fed Microbiome, a book on the microbiome and diet written for the general public.