An introduction to the Fundamentals of Biomedical Science series |
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ix | |
Contributors |
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xiii | |
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xv | |
Abbreviations |
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xvii | |
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1 Haematology and Haemopoiesis |
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1 | (72) |
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1 Introduction to haematology |
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3 | (13) |
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3 | (3) |
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1.2 The role of the biomedical scientist in the haematology laboratory |
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6 | (4) |
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1.3 The role of haematology in the provision of healthcare |
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10 | (2) |
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1.4 The role of the professional body |
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12 | (4) |
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2 Major haematology parameters and basic techniques |
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16 | (36) |
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17 | (1) |
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18 | (1) |
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2.3 An introduction to major techniques |
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19 | (11) |
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30 | (2) |
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32 | (6) |
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38 | (2) |
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40 | (1) |
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40 | (6) |
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46 | (2) |
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48 | (4) |
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3 Haemopoiesis and the bone marrow |
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52 | (21) |
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3.1 Overview of the cellular constituents of the blood |
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52 | (1) |
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3.2 Ontogeny of haemopoiesis |
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53 | (1) |
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3.3 Bone marrow architecture and cellularity |
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54 | (1) |
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3.4 Models of differentiation, stem cells, and growth factors |
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55 | (5) |
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3.5 Specific lineage haemopoiesis |
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60 | (6) |
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3.6 Bone marrow sampling and analysis |
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66 | (7) |
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2 Peripheral Blood Cells in Health and Disease |
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73 | (192) |
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4 The red blood cell in health and disease |
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75 | (38) |
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4.1 The development of the red blood cell: erythropoiesis |
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76 | (5) |
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4.2 The red blood cell membrane |
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81 | (8) |
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4.3 The cytoplasm of the red blood cell |
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89 | (13) |
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4.4 The death of the red cell |
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102 | (2) |
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104 | (5) |
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4.6 An introduction to diseases of the red cell |
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109 | (4) |
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5 Anaemia 1: The bone marrow, micronutrients, and disease in other organs |
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113 | (39) |
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5.1 Introduction to anaemia |
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114 | (3) |
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5.2 Anaemia arising from changes in the bone marrow |
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117 | (4) |
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121 | (5) |
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126 | (4) |
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5.5 The role of the laboratory in iron-related pathology |
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130 | (4) |
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5.6 Anaemia arising from lack of vitamins |
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134 | (12) |
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5.7 Anaemia of chronic disease (ACD) |
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146 | (6) |
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152 | (41) |
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6.1 Introduction to haemolytic anaemia |
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152 | (2) |
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6.2 Immune-mediated and other `extrinsic' causes of haemolytic anaemia |
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154 | (9) |
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163 | (21) |
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184 | (4) |
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6.5 Principal enzyme defects |
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188 | (5) |
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193 | (36) |
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193 | (1) |
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194 | (22) |
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216 | (2) |
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218 | (3) |
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221 | (1) |
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222 | (7) |
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8 White blood cells in health and disease |
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229 | (36) |
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230 | (1) |
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230 | (18) |
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248 | (2) |
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250 | (13) |
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263 | (2) |
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3 Haematological Malignancies |
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265 | (156) |
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9 An introduction to haematological malignancies |
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267 | (39) |
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9.1 A background to haematological malignancies |
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268 | (5) |
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273 | (1) |
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9.3 An introduction to the cell cycle |
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274 | (4) |
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278 | (1) |
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279 | (2) |
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9.6 Chromosomes and nomenclature |
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281 | (2) |
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9.7 An introduction to genetic mutation |
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283 | (9) |
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292 | (3) |
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295 | (4) |
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9.10 Mechanisms of oncogenesis |
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299 | (1) |
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9.11 Inheritance and leukaemia |
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300 | (1) |
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9.12 Environmental causes of haematological malignancies |
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301 | (5) |
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10 The laboratory investigation of haematological malignancies |
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306 | (35) |
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10.1 Patient presentation |
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307 | (2) |
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10.2 The full blood count |
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309 | (3) |
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312 | (2) |
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10.4 Bone marrow assessment |
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314 | (7) |
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321 | (3) |
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324 | (8) |
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10.7 Cytogenetic analysis |
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332 | (4) |
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10.8 Molecular techniques |
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336 | (5) |
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11 An introduction to classification systems: myeloid neoplasms |
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341 | (36) |
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11.1 Why is classification important? |
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342 | (1) |
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11.2 The main classification systems |
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342 | (17) |
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11.3 Myelodysplastic syndrome |
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359 | (6) |
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11.4 Myelodysplastic/myeloproliferative diseases |
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365 | (2) |
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11.5 Myeloproliferative neoplasms |
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367 | (10) |
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12 An introduction to classification systems: lymphoid neoplasms |
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377 | (44) |
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12.1 The World Health Organization (WHO) classification of tumours of haematopoietic and lymphoid tissues |
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378 | (3) |
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12.2 WHO classification of precursor lymphoid neoplasms |
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381 | (5) |
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12.3 Mature B-cell neoplasms |
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386 | (27) |
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12.4 Mature T-cell and NK-cell neoplasms |
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413 | (3) |
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416 | (5) |
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4 Haemostasis in Health and Disease |
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421 | (192) |
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423 | (38) |
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13.1 Introduction to haemostasis |
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423 | (1) |
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424 | (11) |
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13.3 Secondary haemostasis |
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435 | (12) |
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13.4 Regulation of secondary haemostasis |
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447 | (6) |
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453 | (8) |
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14 Bleeding disorders and their laboratory investigation |
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461 | (46) |
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461 | (4) |
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14.2 Laboratory investigation of a suspected bleeding disorder |
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465 | (25) |
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14.3 Diagnosis of platelet disorders |
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490 | (17) |
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507 | (38) |
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507 | (2) |
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15.2 Deficiency of the natural anticoagulants |
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509 | (6) |
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15.3 Gain-of-function mutations |
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515 | (3) |
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15.4 Other thrombophilias |
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518 | (1) |
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15.5 Pitfalls of thrombophilia testing |
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519 | (4) |
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15.6 Antiphospholipid antibodies |
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523 | (17) |
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540 | (5) |
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16 Acquired disorders of haemostasis |
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545 | (23) |
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16.1 Acquired bleeding disorders |
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545 | (16) |
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16.2 Acquired thrombotic disorders |
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561 | (7) |
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17 Haemostasis and anticoagulation |
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568 | (45) |
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17.1 Reasons for anticoagulation therapy |
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568 | (5) |
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17.2 Current therapeutic anticoagulant pharmaceuticals for VTE |
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573 | (11) |
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17.3 Current therapeutic anticoagulant pharmaceuticals for arterial thrombosis |
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584 | (1) |
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17.4 Laboratory monitoring of anticoagulant therapy |
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585 | (18) |
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17.5 Management of VKA anticoagulant therapy |
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603 | (10) |
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613 | (14) |
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18 Case studies in haematology |
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615 | (12) |
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615 | (4) |
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619 | (3) |
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622 | (5) |
Glossary |
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627 | (19) |
References |
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646 | (1) |
Index |
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647 | |