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Haematology 2nd Revised edition [Mīkstie vāki]

4.25/5 (19 ratings by Goodreads)
(Consultant Biomedical Scientist and Head of Diagnostic Haemostasis & Thrombosis Laboratory, Centre for Haemostasis and Thrombosis, St. Thomas' Hospital, London), , (Principal Lecturer in Haematology, School of Pharmacy and Biomedical Sci)
  • Formāts: Paperback / softback, 688 pages, height x width x depth: 246x190x26 mm, weight: 1430 g, 200 colour line illustrations, 150 colour halftones
  • Sērija : Fundamentals of Biomedical Science
  • Izdošanas datums: 18-Feb-2016
  • Izdevniecība: Oxford University Press
  • ISBN-10: 0199668868
  • ISBN-13: 9780199668861
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  • Formāts: Paperback / softback, 688 pages, height x width x depth: 246x190x26 mm, weight: 1430 g, 200 colour line illustrations, 150 colour halftones
  • Sērija : Fundamentals of Biomedical Science
  • Izdošanas datums: 18-Feb-2016
  • Izdevniecība: Oxford University Press
  • ISBN-10: 0199668868
  • ISBN-13: 9780199668861
Citas grāmatas par šo tēmu:
Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible.

The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science.

Haematology provides a broad-ranging overview of the study of blood, the dynamic fluid that interfaces with all organs and tissues to mediate essential transport and regulatory functions.

Written with the needs of the biomedical scientist centre-stage, it provides a firm grounding in the physiology of blood, and the key pathophysiological states that can arise. It demonstrates throughout how an understanding of the physiology underpins the key investigations carried out by a biomedical scientist to forge a clear link between science and practice. The second edition includes a new chapter on acquired disorders of haemostasis.

Online Resource Centre
The Online Resource Centre to accompany Haematology features:

For registered adopters of the book:
DT Figures from the book, available to download

For students:
DT Answers to case study and self-check questions.
DT An interactive Digital Microscope, encouraging the exploration of tissue samples
DT Video podcasts including interviews with practicing biomedical scientists, and 'in the lab' footage showing biomedical science in practice

Recenzijas

Review from previous edition A very good resource. Chapters are very well elaborated with latest up to date in depth information. Inclusion of learning objectives, summaries and in particular key terms and key points gives it advantage over many other texts currently available. * Indu Singh, School of Medical Sciences, RMIT University * Covers a range of haematological topics that are both up to date and very comprehensive. * Gordon Lowe, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University *

Papildus informācija

Winner of the Royal Society of Biology Undergraduate Textbook Prize 2016
An introduction to the Fundamentals of Biomedical Science series ix
Contributors xiii
Table 1 Reference Ranges
xv
Abbreviations xvii
1 Haematology and Haemopoiesis
1(72)
1 Introduction to haematology
3(13)
1.1 What is haematology?
3(3)
1.2 The role of the biomedical scientist in the haematology laboratory
6(4)
1.3 The role of haematology in the provision of healthcare
10(2)
1.4 The role of the professional body
12(4)
2 Major haematology parameters and basic techniques
16(36)
2.1 Obtaining a sample
17(1)
2.2 Anticoagulants
18(1)
2.3 An introduction to major techniques
19(11)
2.4 The blood film
30(2)
2.5 The full blood count
32(6)
2.6 Rheology
38(2)
2.7 The report form
40(1)
2.8 Haemostasis
40(6)
2.9 Haematinics
46(2)
2.10 The reference range
48(4)
3 Haemopoiesis and the bone marrow
52(21)
3.1 Overview of the cellular constituents of the blood
52(1)
3.2 Ontogeny of haemopoiesis
53(1)
3.3 Bone marrow architecture and cellularity
54(1)
3.4 Models of differentiation, stem cells, and growth factors
55(5)
3.5 Specific lineage haemopoiesis
60(6)
3.6 Bone marrow sampling and analysis
66(7)
2 Peripheral Blood Cells in Health and Disease
73(192)
4 The red blood cell in health and disease
75(38)
4.1 The development of the red blood cell: erythropoiesis
76(5)
4.2 The red blood cell membrane
81(8)
4.3 The cytoplasm of the red blood cell
89(13)
4.4 The death of the red cell
102(2)
4.5 Red cell morphology
104(5)
4.6 An introduction to diseases of the red cell
109(4)
5 Anaemia 1: The bone marrow, micronutrients, and disease in other organs
113(39)
5.1 Introduction to anaemia
114(3)
5.2 Anaemia arising from changes in the bone marrow
117(4)
5.3 Insufficient iron
121(5)
5.4 Iron overload
126(4)
5.5 The role of the laboratory in iron-related pathology
130(4)
5.6 Anaemia arising from lack of vitamins
134(12)
5.7 Anaemia of chronic disease (ACD)
146(6)
6 Anaemia 2: Haemolysis
152(41)
6.1 Introduction to haemolytic anaemia
152(2)
6.2 Immune-mediated and other `extrinsic' causes of haemolytic anaemia
154(9)
6.3 Haemoglobinopathy
163(21)
6.4 Membrane defects
184(4)
6.5 Principal enzyme defects
188(5)
7 Blood-borne parasites
193(36)
7.1 Introduction
193(1)
7.2 Malaria
194(22)
7.3 Babesiosis
216(2)
7.4 Trypanosomiasis
218(3)
7.5 Leishmaniasis
221(1)
7.6 Filariasis
222(7)
8 White blood cells in health and disease
229(36)
8.1 Introduction
230(1)
8.2 Granulocytes
230(18)
8.3 Monocytes
248(2)
8.4 Lymphocytes
250(13)
8.5 Plasma cells
263(2)
3 Haematological Malignancies
265(156)
9 An introduction to haematological malignancies
267(39)
9.1 A background to haematological malignancies
268(5)
9.2 Signal transduction
273(1)
9.3 An introduction to the cell cycle
274(4)
9.4 Apoptosis
278(1)
9.5 Cancer stem cells
279(2)
9.6 Chromosomes and nomenclature
281(2)
9.7 An introduction to genetic mutation
283(9)
9.8 Epigenetics
292(3)
9.9 Clonality
295(4)
9.10 Mechanisms of oncogenesis
299(1)
9.11 Inheritance and leukaemia
300(1)
9.12 Environmental causes of haematological malignancies
301(5)
10 The laboratory investigation of haematological malignancies
306(35)
10.1 Patient presentation
307(2)
10.2 The full blood count
309(3)
10.3 Blood film
312(2)
10.4 Bone marrow assessment
314(7)
10.5 Cytochemistry
321(3)
10.6 Immunophenotyping
324(8)
10.7 Cytogenetic analysis
332(4)
10.8 Molecular techniques
336(5)
11 An introduction to classification systems: myeloid neoplasms
341(36)
11.1 Why is classification important?
342(1)
11.2 The main classification systems
342(17)
11.3 Myelodysplastic syndrome
359(6)
11.4 Myelodysplastic/myeloproliferative diseases
365(2)
11.5 Myeloproliferative neoplasms
367(10)
12 An introduction to classification systems: lymphoid neoplasms
377(44)
12.1 The World Health Organization (WHO) classification of tumours of haematopoietic and lymphoid tissues
378(3)
12.2 WHO classification of precursor lymphoid neoplasms
381(5)
12.3 Mature B-cell neoplasms
386(27)
12.4 Mature T-cell and NK-cell neoplasms
413(3)
12.5 Hodgkin lymphoma
416(5)
4 Haemostasis in Health and Disease
421(192)
13 Normal haemostasis
423(38)
13.1 Introduction to haemostasis
423(1)
13.2 Primary haemostasis
424(11)
13.3 Secondary haemostasis
435(12)
13.4 Regulation of secondary haemostasis
447(6)
13.5 Fibrinolysis
453(8)
14 Bleeding disorders and their laboratory investigation
461(46)
14.1 Bleeding disorders
461(4)
14.2 Laboratory investigation of a suspected bleeding disorder
465(25)
14.3 Diagnosis of platelet disorders
490(17)
15 Thrombophilia
507(38)
15.1 Introduction
507(2)
15.2 Deficiency of the natural anticoagulants
509(6)
15.3 Gain-of-function mutations
515(3)
15.4 Other thrombophilias
518(1)
15.5 Pitfalls of thrombophilia testing
519(4)
15.6 Antiphospholipid antibodies
523(17)
15.7 Thrombosis
540(5)
16 Acquired disorders of haemostasis
545(23)
16.1 Acquired bleeding disorders
545(16)
16.2 Acquired thrombotic disorders
561(7)
17 Haemostasis and anticoagulation
568(45)
17.1 Reasons for anticoagulation therapy
568(5)
17.2 Current therapeutic anticoagulant pharmaceuticals for VTE
573(11)
17.3 Current therapeutic anticoagulant pharmaceuticals for arterial thrombosis
584(1)
17.4 Laboratory monitoring of anticoagulant therapy
585(18)
17.5 Management of VKA anticoagulant therapy
603(10)
5 Case Studies
613(14)
18 Case studies in haematology
615(12)
18.1 Case study 1
615(4)
18.2 Case study 2
619(3)
18.3 Case study 3
622(5)
Glossary 627(19)
References 646(1)
Index 647