Provides a comprehensive view of fundamental aspects of development, the agents involved, clinical syndromes induced, and risk assessment procedures for developmental neurotoxicants. Sections cover cellular and molecular morphogenesis of the nervous system; developmental biology/toxicology; synaptogenesis and neurotransmission; nutrient and chemical disposition; behavioral assessment; clinical assessment and epidemiology; specific neurotoxic syndromes; and risk assessment. Includes b&w diagrams and charts, and case studies. For students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Annotation c. by Book News, Inc., Portland, Or.
The Handbook of Developmental Neurotoxicology provides a comprehensive account of the impacts, mechanisms, and clinical relevances of chemicals on the development of the nervous system. The book is written by internationally recognized experts on developmental neurotoxicology, covering subjects from basic neuro-development to toxic syndromes induced by various chemicals. It is an important text for both students and professionals who are interested in developmental neurobiology and neurotoxicology.
Key Features
* Written by internationally recognized experts on developmental neurotoxicology
* Includes extensive references
* Well illustrated with diagrams, charts and tables
* Provides coverage of basic neurobiology as well as neurotoxicology
Papildus informācija
Key Features * Written by internationally recognized experts on developmental neurotoxicology * Includes extensive references * Well illustrated with diagrams, charts and tables * Provides coverage of basic neurobiology as well as neurotoxicology
Contributors xi(4) Foreword xv(2) Preface xvii Part I Cellular and Molecular Morphogenesis of the Nervous System 1(116) AN INTRODUCTORY OVERVIEW 1(2) Louis W. Chang 1 BRAIN MORPHOGENESIS AND DEVELOPMENTAL NEUROTOXICOLOGY 3(40) Karl F. Jensen Susan M. Catalano 2 CADHERIN CELL ADHESION MOLECULES IN NORMAL AND ABNORMAL NEURAL DEVELOPMENT 43(18) Gerald B. Grunwald 3 NEURITE DEVELOPMENT 61(26) Gerald Audesirk Teresa Audesirk 4 MYELINATION, DYSMYELINATION, AND DEMYELINATION 87(30) G. Jean Harry Arrel D. Toews Part II Developmental Biology/Toxicology 117(106) AN INTRODUCTORY OVERVIEW 117(2) Thomas Sadler 5 SIGNAL TRANSDUCTION PATHWAYS AS TARGETS FOR INDUCED EMBRYOTOXICITY 119(22) Robert M. Greene Paul Nugent M. Michele Pisano Wayde Weston Merle Potchinsky 6 TROPHIC NERVE GROWTH FACTORS 141(12) Haeyoung Kong Patrizia Casaccia-Bonnefil Moses V. Chao 7 NEUROTOXIC AND NEUROTROPHIC EFFECTS OF GABAergic AGENTS ON DEVELOPING NEUROTRANSMITTER SYSTEMS 153(6) Jean M. Lauder Jiangping Liu 8 APOPTOSIS 159(30) Margaret A. Shield Philip E. Mirkes 9 PERIODS OF SUSCEPTIBILITY TO INDUCED MALFORMATIONS OF THE DEVELOPING MAMMALIAN BRAIN 189(20) Gregory D. Bennett Richard H. Finnell 10 TRANSGENIC ANIMAL MODELS: FUNCTIONAL ANALYSIS OF DEVELOPMENTAL TOXICITY AS ILLUSTRATED WITH THE p53 SUPPRESSOR MODEL 209(14) Thomas B. Knudsen Judith A. Wubah Part III Synaptogenesis and Neurotransmission 223(82) AN INTRODUCTORY OVERVIEW 223(2) Tomas R. Guilarte 11 NEURAL CREST CELL MIGRATION 225(20) Andrew G. Hendrickx Pamela E. Peterson 12 ONTOGENY OF NEUROTRANSMITTERS: MONOAMINES 245(12) Harry W. Broening William Slikker, Jr. 13 CENTRAL CHOLINERGIC NEUROBIOLOGY 257(18) David A. Jett 14 ONTOGENY OF SECOND MESSENGER SYSTEMS 275(10) Lucio G. Costa 15 THE N-METHYL-D-ASPARTATE RECEPTOR: PHYSIOLOGY AND NEUROTOXICOLOGY IN THE DEVELOPING BRAIN 285(20) Tomas R. Guilarte Part IV Nutrient and Chemical Disposition 305(96) AN INTRODUCTORY OVERVIEW 305(2) William Slikker, Jr. 16 PB/PK MODELS 307(14) Ellen J. OFlaherty 17 DEVELOPMENTAL ENZYMOLOGY: XENOBIOTIC BIOTRANSFORMATION 321(18) Mont R. Juchau Hao Chen 18 BLOOD-BRAIN BARRIER: PHYSIOLOGICAL AND FUNCTIONAL CONSIDERATIONS 339(14) Michael Aschner 19 ANTIOXIDANT ENZYMES: DEVELOPMENTAL PROFILES AND THEIR ROLE IN METAL-INDUCED OXIDATIVE STRESS 353(18) Saber Hussain Syed F. Ali 20 FOOD AND NUTRIENT EXPOSURE THROUGHOUT THE LIFE SPAN: HOW DOES WHAT WE EAT TRANSLATE INTO EXPOSURE, DEFICIENCIES, AND TOXICITIES? 371(12) Margaret L. Bogle 21 DRUG AND CHEMICAL CONTAMINANTS IN BREAST MILK: EFFECTS ON NEURODEVELOPMENT OF THE NURSING INFANT 383(18) Janine E. Polifka Part V Behavioral Assessment 401(36) AN INTRODUCTORY OVERVIEW 401(2) Jerrold S. Meyer 22 BEHAVIORAL ASSESSMENT IN DEVELOPMENTAL NEUROTOXICOLOGY: APPROACHES INVOLVING UNCONDITIONED BEHAVIORS AND PHARMACOLOGIC CHALLENGES IN RODENTS 403(24) Jerrold S. Meyer 23 ASSESSMENT OF BEHAVIOR IN PRIMATES 427(10) Merle G. Paule Part VI Clinical Assessment and Epidemiology 437(68) AN INTRODUCTORY OVERVIEW 437(2) J. M. Friedman 24 EVALUATION OF THE HUMAN NEWBORN INFANT 439(16) Anneloes van Baar 25 DEVELOPMENTAL EVALUATION OF THE OLDER INFANT AND CHILD 455(14) Claire D. Coles Julie A. Kable 26 BEHAVIORAL EVALUATION OF THE OLDER INFANT AND CHILD 469(18) Peter A. Fried 27 EPIDEMIOLOGIC STUDIES OF THE EFFECTS OF PRENATAL COCAINE EXPOSURE ON CHILD DEVELOPMENT AND BEHAVIOR 487(10) Gale A. Richardson Nancy L. Day 28 ASSESSMENT OF CASE REPORTS AND CLINICAL SERIES 497(8) J. M. Friedman Part VII Specific Neurotoxic Syndromes 505(168) AN INTRODUCTORY OVERVIEW 505(2) Louis W. Chang 29 FETAL MINAMATA DISEASE: CONGENITAL METHYLMERCURY POISONING 507(10) Louis W. Chang Grace Liejun Guo 30 DEVELOPMENTAL NEUROTOXICITY OF CADMIUM 517(22) Lloyd Hastings Marian L. Miller 31 DEVELOPMENTAL LEAD EXPOSURE: NEUROBEHAVIORAL CONSEQUENCES 539(20) Deborah C. Rice 32 DEVELOPMENTAL TOXICITY OF PESTICIDES 559(8) Durisala Desaiah 33 THE EFFECTS OF ALCOHOL ON THE FETAL BRAIN: THE CENTRAL NERVOUS SYSTEM TRAGEDY 567(20) Irena Nulman Bonnie OHayon Jonathan Gladstone Gideon Koren 34 DEVELOPMENTAL NEUROTOXICITY OF NICOTINE 587(30) Edward D. Levin Theodore A. Slotkin 35 MATERNAL DRUG ABUSE AND ADVERSE EFFECTS ON NEUROBEHAVIOR OF OFFSPRING 617(14) Merle G. Paule 36 THE NEUROBEHAVIORAL TERATOLOGY OF VITAMIN A ANALOGS 631(12) Jane Adams R. Robert Holson 37 DEVELOPMENTAL NEUROTOXICITY OF ANTIEPILEPTIC DRUGS 643(18) Deborah K. Hansen R. Robert Holson 38 NEUROTERATOLOGY OF AUTISM 661(12) Patricia M. Rodier Part VIII Risk Assessment 673(60) AN INTRODUCTORY OVERVIEW 673(2) William Slikker, Jr. 39 CURRENT APPROACHES TO RISK ASSESSMENT FOR DEVELOPMENTAL NEUROTOXICITY 675(12) Carole A. Kimmel 40 ANIMAL/HUMAN CONCORDANCE 687(22) James L. Schardein 41 PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS IN THE RISK ASSESSMENT OF DEVELOPMENTAL NEUROTOXICANTS 709(18) Kannan Krishnan Melvin Andersen 42 QUANTITATIVE MODELS OF RISK ASSESSMENT FOR DEVELOPMENTAL NEUROTOXICANTS 727(6) William Slikker, Jr. David W. Gaylor Index 733
Dr. William Slikker, Jr. was the director of FDAs National Center for Toxicological Research (NCTR) before his retirement. He received his Ph.D. in pharmacology and toxicology from the University of California at Davis. Dr. Slikker holds adjunct professorships in the Department of Pediatrics, as well as the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences. He has held committee chairmanships or elected offices in several scientific societies including the Teratology Society (serving as president) and the American Society for Pharmacology and Experimental Therapeutics (chair, Developmental Pharmacology Section and member, Program Committee). Dr. Slikker is also the co-founder and past president of the MidSouth Computational Biology and Bioinformatics Society. He is currently associate editor for NeuroToxicology and associate editor for the Environmental Health section of Experimental Biology and Medicine. He is the past president of The Academy of Toxicological Sciences and the Society of Toxicology. He is a recipient of the 2014 George H. Scott Memorial Award from The Toxicology Forum and was invited to present the Warkany Lecture at the 2015 annual meeting of the Teratology Society. In early 2019, the Academy of Toxicological Sciences selected Dr. Slikker to receive the prestigious Mildred S. Christian Career Achievement Award. The Society for Birth Defects Research and Prevention selected Dr. Slikker to be the recipient of the 2022 Edward W. Carney Distinguished Service Award.
Dr. Slikker has authored or co-authored over 380 publications in the areas of transplancentalpharmacokinetics, developmental neurotoxicology, neuroprotection, systems biology, and risk assessment. Dr. Slikkers recent research has highlighted the concern for thousands of infants and toddlers who undergo longer-duration general anesthesia. He has performed research with his team and published over 25 peer-reviewed papers outlining the issue of brain-cell death and cognitive-function deficits in animal models that may result from several hours of anesthesia at a critical time of development. He has also, with the use of in vitro and in vivo techniques in rodents and nonhuman primates, defined possible mechanisms of toxicity and protective pathways to prevent the detrimental effects of general anesthesia. Through these and related scientific contributions, he has identified and characterized a host of minimally invasive biomarkers of neurotoxicity including the use of preclinical imaging (MRI, MicroPET/CT), genomic and lipidomic analysis, and modeling approaches to characterize and quantify adult and developmental neurotoxicity. He has also served on several national/international advisory panels for ILSI, HESI, CIIT, EPA, NIEHS, NAS, NIH and WHO. Louis W. Chang is a Professor in the Departments of Pathology, Pharmacology, and Toxicology at the University of Arkansas for Medical Sciences. He also served as the Director of the Toxicology Program and is the current Graduate Director of the Pathology Program in Arkansas. Aside from being the author of over 200 scientific articles, Dr. Chang also served on the editorial boards for a number of publications and scientific journals in his field. He is a well recognized scientist internationally. Dr. Chang has been recently elected as a Fellow of the Academy of Toxicological Sciences and has become a board certified Diplomate of the American Board of Forensic Examiners and a Diplomate of the American Board of Forensic Medicine. He received his B.A. from the University of Massachusetts, Amherst, his M.S. in Anatomy and Histochemistry from the Tufts University School of Medicine, and his Ph.D. in Pathology from the University of Wisconsin, Madison Medical School. Dr. Chang also received education and training from Harvard Medical School and the University of California, Los Angeles School of Medicine.
