This handbook provides comprehensive coverage of the role of proteases and the associated biochemical pathways in cancer development and metastasis. Proteases make up about 2% of the human genome and play a critical role in the tumor microenvironment. Handbook of Proteases in Cancer: Cellular and Molecular Aspects introduces the major classes of proteases and the signal transduction mechanisms associated with cancer initiation and progression. It discusses the role of inflammation and immune responses in proteases-induced cancer. The book covers cancer-induced gene expression and apoptotic and necrotic pathways in cancer. This is useful for researchers and professionals in cancer research, biochemistry, and physiology.
Key Features
Provides insights on the roles of proteases and anti-proteases in the tumor microenvironment.
Covers various cancer-induced apoptotic and necrotic pathways.
Discusses the mechanisms by which proteases induce an increase in inflammation, immune
response, and gene expression.
Covers the function of protease-activated receptors in cancer.
Reviews the different gene expression pathways and the ways they become erratic during
protease-induced cancer.
..I. General Aspects .. 1.1. Calpain as a therapeutic target in B-cell
lymphoma and other malignant diseases. 1.2 Proteases in cancer: Theoretical
insights on the proteases evolutionary pathway.
1. 3 Role of extracellular
proteases in Glioblastoma .
1. 4 Metalloprotease in colon cancer
proliferation and metastasis. 1.5 Role of proteolytic enzymes in colon
cancer. 1.6. Tumor associated fibroblast and ADAMS orchestrate tumor
microenvironment in hepatocellular carcinoma. 1.7 Unmasking the Protease
Paradigm: Exploring the Molecular .Complexity of Proteases in Breast Cancer.
1. 8 Roles of MM7 in cancer. 1.9. The Role of Matrix Metalloproteinases MMP2
and MMP9 in Ovarian Cancer Progression. II. Signal Transduction
Mechanisms..2.1. Role of calpains in cancer: an overview .2.2. Dual role of
the ADAMTS family in breast cancer. 2.3. PKC isoforms and autophagy in
cancer.2.4. Mechanistic insights into the ferroptotic regulation of ubiquitin
specific proteases in gastrointestinal tumors.2.5. Serine proteases as
critical modulators of the tumor microenvironment..2.6. Protease paradigm in
cancer progression: Roles of Caspase-8 and matrix metalloproteinase family in
cancer with special reference to head and neck squamous cell carcinoma..2.7.
ENTPDs in the tumor microenvironment: A promising context for cancer
diagnosis..2.8 Matrix Metalloproteases in Breast Cancer.2.9. Targeting
EGFR-driven signaling of MMP-2 secretion for the management of metastatic
cancers..: 2.10 Protease in Signal Transduction Mechanism in Cancer:
Unraveling the Role of Proteolytic Enzymes in Tumor Progression. 2.11.
Sirtuin inhibition modifies matrix metalloproteinases in cancer..2.12. 2.13
The role of matrix metalloproteinase in molecular and cellular aspects of
oral squamous cell carcinoma...2.14 The dichotomous role of CHIP in
cancer...III. Gene expression, apoptosis and necrosis..3.1 Mechanisms of
apoptotic/necrotic cell death-related proteases: Cysteine and serine
proteases.3.2. Apoptotic and non-apoptotic roles of caspases..3.3. Role of
cysteine proteases and matrix metalloproteases in apoptosis and necrosis in
cancer . 3.4. Role of SIRT1 in the regulation of gene expressions in breast
cancer. .3.5. Future Vision of Protease Inhibitors in Context of Cocktail and
Singular Therapy..3.6. Regulation of cell death by cysteine proteases in
breast cancer. 3.7. Ubiquitin Specific Protease 7 (USP7) Role in human
pathologies and potential targeting opportunities in cancer
Dr. Sajal Chakraborti is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did postdoctoral research at the Johns Hopkins Medical Institution, New York Medical College, the University of Utah, and the University of Florida. He has over 35 years of teaching and independent research experience in Biochemistry and Cell Biology. He has published over 110 original research papers, 15 review articles, and 12 books.
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