This handbook comprehensively explores various facets of stem cells and their secretome in the field of regenerative medicine, covering topics such as the biology, characteristics, and applications of mesenchymal and non-mesenchymal stem cells in diverse medical contexts. It delves into their potential for treatment of radiation injuries, diabetes, aging-related diseases, osteoarthritis, Alzheimer's disease, and oral surgery. Furthermore, it investigates the potential of neuronal stem cells for neural repair, myoblast implants for Duchenne muscular dystrophy, and immunotherapy using non-genetically modified natural killer cells. The book also uncovers the possibilities of botanical leads for stem cell therapy, explores the role of stem cells in promoting healthy aging, and sheds light on their complex interplay with cancer, particularly in gliomas and gynecologic cancers. Additionally, it reviews the use of stem cell-derived insoluble factors, focusing on extracellular vesicles as therapeutic agents in dentistry, cardiovascular diseases, and neurodegenerative disorders. The chapters discuss the potential of engineering mesenchymal stem cells secretome for bone regeneration and treating intracerebral hemorrhage. Towards the end, the book elucidates cell-free scaffolding for tissue engineering, adult stem cells' disease tropism, and the evolving strategies in regenerative medicine. It is intended for researchers, professionals, and academicians in the fields of regenerative medicine, stem cell biology, and medical biotechnology.
Key Features:
- Addresses the biology, characteristics, and applications of both mesenchymal and non-mesenchymal stem cells in diverse medical contexts.
- Presents applications of stem cells for the treatment of various medical conditions, including radiation injuries, diabetes, aging-related diseases, osteoarthritis, Alzheimer's disease, and oral surgery.
- Covers neuronal stem cells for neural repair, myoblast implants for Duchenne muscular dystrophy, and immunotherapy using non-genetically modified natural killer cells.
- Explores the potential of botanical compounds for stem cell therapy, bridging traditional medicine with modern approaches.
- Discusses therapeutic potential of the stem cell-derived secretome in dentistry, cardiovascular diseases, and neurodegenerative disorders.
This handbook discusses applications of stem cells and their secretome in regenerative medicine, covering their biology, applications, and therapeutic potential in various medical contexts, like diabetes, cancer, and neurological disorders. It is useful for researchers and professionals in regenerative medicine and stem cell biology.
Chapter
1. Mesenchymal Stromal Cell: Basic characteristics and
Interaction with the Immune System.
Chapter
2. Significant Progress in Stem
Cell Treatment for Alzheimers Disease: A Critical Review.
Chapter
3.
Regenerative Medicine in Ophthalmology.
Chapter
4. Cell Therapy for Diabetes.
Chapter
5. Revisiting Preclinical and Clinical Trials of Mesenchymal Stem
Cells in Heart Disease to Define a Dose-Response.
Chapter
6. Stemming Pain
Sensations with Stem Cells.
Chapter
7. Osteoarthritis treatment between
bio-stimulation and cell therapy.
Chapter
8. Cellular Architects of Healing:
Mesenchymal Stem Cell-Based Strategies for Fibrosis.
Chapter
9. Stem cells
and mineralized plasmatic matrix therapy in oral surgery.
Chapter
10. Role of
stem cell-based therapy in neurodegenerative, ocular, and cardiovascular
disease.
Chapter
11. Stem Cells Regenerative Therapy in Cardiac Disease:
Lessons from Embryonic Development, Current Evidence for Clinical Application
and Potential Future Directions.
Chapter
12. Challenges And Opportunities in
the Study of Bone Marrow-Derived Mesenchymal Stromal Cells: From Where We
Stand to Where We Go.
Chapter
13. Mesenchymal stem cell-mediated therapy in
regenerative medicine.
Chapter
14. Routes of Administration of Mesenchymal
Stem Cell Therapy in Cardiac Therapy.
Chapter
15. Neuronal Stem Cells and
Regenerative Medicine: Harnessing the Potential for Neural Repair.
Chapter
16. Biomaterial Nanofiber Scaffolds for Neural Regeneration.
Chapter
17.
Cell-free and Cell-based Therapy in Treating Spinal Cord Injuries.
Chapter
18. 20-Year Life Prolongation Achieved through Muscle Regeneration by
Implanting 50-Billion Allogeneic Myoblasts into Duchenne Muscular Dystrophy
(DMD) Boys.
Chapter
19. Reversing Insulin Resistance by Novel Cell-based and
Cell-free Therapy Approaches with Skeletal Myoblasts.
Chapter
20. Current
progress and challenges of non-genetically modified natural killer (NK)
cell-based immunotherapy.
Chapter
21. Identification of Potential Botanical
Drug Leads for Stem Cell Therapy: Cues from Sri Lankan Traditional Medicine.
Chapter
22. Cell-based Therapy for Cancer in Regenerative Medicine.
Chapter
23. Lung regeneration against lung diseases: a near future reality?
Chapter
24. The pivotal role of glioma stem cells in promoting glioma
radio-chemoresistance, progression, and recurrence is a topic of significant
interest and potential breakthroughs in neurosurgery, oncology, and molecular
biology.
Chapter
25. Significance of Targeting Cancer Stem Cells in
Gynaecologic Cancer.
Chapter
26. Role of Stem Cells in diabetes, liver
disease, and cancer treatment.
Chapter
27. Pluripotent Stem Cells: A Hope to
Move Forward for Cardiovascular Applications.
Dr. Khawaja Husnain Haider is a Professor of Cellular and Molecular Pharmacology (Stem Cell and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University. Before his current assignment, he served in several prestigious institutions in various parts of the world. He has also served as Principal Investigator (PI) and Co-PI on multiple National Institute of Health (NIH) funded stem cell research projects. He has been on the editorial boards and invited reviewer panels for several respected international journals. His research focuses on using, either alone or in combination, DNA, miRNAs, and stem cells as drugs, a topic that has gained popularity in regenerative medicine. He has extensively published on cellular and sub-cellular preconditioning of stem cells and using their conditioned media for cell-free therapy. He has published nearly 350 book chapters, abstracts, and research papers in various books and leading research journals, including Circulation, Circulation Research, Cardiovascular Research, JCMM, the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling. He has also given numerous presentations and edited ten books covering various facets of stem cells and their applications from drug to drug development.
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