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E-grāmata: Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications

Edited by (University of British Columbia, Vancouver, Canada), Edited by (University of Patras, Greece), Edited by (University of Patras, Greece), Edited by (Technological Educational Institute of Athens, Egaleo, Greece)
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The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans.

Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research.

The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.

Recenzijas

"A great overview of current small animal imaging modalities describing their principles of operation, equipment components, and most recent applications with extremely helpful illustrations. An essential book for every biologist, chemist, and physicist involved in small animal research." Magdalena Bazalova-Carter, PhD, Department of Physics and Astronomy, University of Victoria

" a superb, comprehensive, and very accurate depiction of the state of the art in small animal imaging technologies and applications. This is an authoritative book and invaluable source of information for all biomedical sciences and technologies students, as well as for educators, professionals, and researchers in this multidisciplinary field." Professor George Kontaxakis, Universidad Politécnica de Madrid

Series Preface xiii
Preface xv
Editors xvii
Contributors xix
SECTION I Introduction to Small Animal Imaging, Therapy, and Applications
Chapter 1 Defining Small Animal Imaging, Therapy, and Applications
3(4)
Nancy L. Ford
George K. Loudos
Dimitrios N. Karnabatidis
George C. Kagadis
Chapter 2 Ethics and Regulations for Research with Animals
7(10)
William R. Hendee
Chapter 3 Small Animal Handling, Care, and Anesthesia
17(18)
Tamara Godbey
Chapter 4 Preclinical Models
35(16)
Irene Cuadrado
Jesus Egido
Jose Luis Zamorano
Carlos Zaragoza
SECTION II Small Animal Imaging: Ionizing Radiation
Chapter 5 Microcomputed Tomography
51(16)
Nancy L. Ford
Chapter 6 Digital Subtracted Angiography of Small Animals
67(10)
Stavros Spiliopoulos
George C. Kagadis
Dimitrios N. Karnabatidis
G. Allan Johnson
Cristian Badea
Chapter 7 Single-Photon Emission Computed Tomography
77(22)
Matthew A. Lewis
Chapter 8 Positron Emission Tomography
99(22)
Vesna Sossi
Matthew Walker
SECTION III Small Animal Imaging: Nonionizing Radiation
Chapter 9 MR Imaging
121(20)
Dmitri Artemov
Chapter 10 Optical Imaging
141(26)
Matthew A. Lewis
SECTION IV Hybrid Imaging
Chapter 11 Optical-CT Imaging
167(20)
Xueli Chen
Dongmei Chen
FengLin Liu
Wenxiang Cong
Ge Wang
Jimin Liang
Chapter 12 PET/CT
187(18)
Mohammad Reza Ay
Nafiseh Ghazanfari
Chapter 13 Introduction to Combining MRI with PET
205(28)
Volkmar Schulz
Jakob Wehner
Yannick Berker
Chapter 14 Exotic Imaging Approaches
233(16)
Maria Koutsoupidou
Irene S. Karanasiou
SECTION V Imaging Agents
Chapter 15 X-Ray, MRI, and Ultrasound Agents: Basic Principles
249(28)
Michael F. Tweedle
Krishan Kumar
Michael V. Knopp
Chapter 16 Radiochemistry for Preclinical Imaging Studies
277(38)
Sven Macholl
Matthias Glaser
Chapter 17 Molecular Targets and Optical Probes
315(14)
Eleni K. Efthimiadou
George Kordas
SECTION VI Therapeutic Research Platforms
Chapter 18 Developing Technologies for Small Animal Radiotherapy
329(24)
Frank Verhaegen
James Stewart
David Jaffray
Chapter 19 Dosimetry of Ionizing Radiation in Small Animal Imaging
353(12)
Michael G. Stabin
Chapter 20 Treatment Planning for Small Animals
365(20)
Frank Verhaegen
Chapter 21 Radiolabeled Agents for Molecular Imaging and/or Therapy
385(24)
Dimitrios Psimadas
Eirini A. Fragogeorgi
SECTION VII Image Quantification
Chapter 22 Quantification in Nuclear Preclinical Imaging
409(14)
Istvan Szanda
Chapter 23 Performance Assessment of Small Animal Imaging Systems and Common Standards
423(12)
Nancy L. Ford
Chapter 24 Monte Carlo Simulations in Imaging and Therapy
435(18)
Panagiotis Papadimitroulas
George C. Kagadis
George K. Loudos
SECTION VIII Applications
Chapter 25 Small Animal Imaging and Therapy: How They Affect Patient Care
453(10)
Lawrence W. Dobrucki
Chapter 26 Applications for Drug Development
463(24)
Jessica Kalra
Donald T. Yapp
Murray Webb
Marcel B. Bally
Chapter 27 Imaging of Intracellular Targets
487(22)
Veerle Kersemans
Chapter 28 Imaging of Cell Trafficking and Cell Tissue Homing
509(18)
Veerle Kersemans
Chapter 29 Imaging of Cardiovascular Disease
527(22)
Aleksandra Kalinowska
Lawrence W. Dobrucki
Chapter 30 Imaging Angiogenesis
549(20)
Lawrence W. Dobrucki
Chapter 31 Imaging of Hypoxia, Apoptosis, and Inflammation
569(10)
Stavros Spillopoulos
Athanasios Diamantopoulos
Chapter 32 Vessel Wall Imaging
579(10)
Stavros Spiliopoulos
Index 589
George C. Kagadis, PhD, FAAPM, is an associate professor of medical physics and medical informatics at the University of Patras. He also holds an adjunct assistant professor appointment at the University of Texas MD Anderson Cancer Center. He is a Greek State Scholarship Foundation grantee, a Fulbright research scholar, and a fellow of the American Association of Physicists in Medicine (AAPM). He has authored about 80 journal papers and presented at more than 20 conferences. He received his PhD in medical physics from the University of Patras. His current research interests focus on medical image processing and analysis, studies in molecular imaging, IHE, and CAD applications.

Nancy L. Ford, PhD, is an assistant professor in the Department of Oral, Biological and Medical Sciences and the director of the Centre for High-Throughput Phenogenomics at the University of British Columbia. She is a full member of the AAPM and an associate editor of Medical Physics. She publishes in journals on medical physics, radiology, and dental science. She received her PhD in medical biophysics from the University of Western Ontario. Her research focuses on preclinical micro-computed tomography imaging and image-based analysis, primarily studying models of respiratory diseases, along with CBCT and MSCT for medical and dental applications.

Dimitrios N. Karnabatidis, PhD, EBIR, is an associate professor of interventional radiology at the University of Patras. He is a fellow of the Cardiovascular and Interventional Radiological Society of Europe and a member of the Hellenic Radiology Society, the Hellenic Society of Interventional Radiology, and the Western Greece Radiology Society. He has been involved as a participant/principal investigator in several national/international research projects and has published 122 articles in peer-reviewed journals. He received his PhD from the School of Medicine, University of Patras. His research interests include angiogenesis in malignant and benign diseases, the augmentation of arteriogenesis in critical limb ischemia, endothelial hyperplasia inhibition after endovascular procedures, and ureteral obstructive diseases.

George K. Loudos, PhD, is an assistant professor in the Department of Biomedical Engineering at the Technological Educational Institute of Athens. He has published 89 articles in international journals and more than 200 papers in conference proceedings. He received his PhD in biomedical engineering from the National Technical University of Athens. His research interests focus on molecular imaging using nuclear medicine techniques and medical instrumentation. He strongly supports interdisciplinary cooperation and education in the field of nanomedicine and molecular imaging.