The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans.
Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research.
The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.
Recenzijas
"A great overview of current small animal imaging modalities describing their principles of operation, equipment components, and most recent applications with extremely helpful illustrations. An essential book for every biologist, chemist, and physicist involved in small animal research." Magdalena Bazalova-Carter, PhD, Department of Physics and Astronomy, University of Victoria
" a superb, comprehensive, and very accurate depiction of the state of the art in small animal imaging technologies and applications. This is an authoritative book and invaluable source of information for all biomedical sciences and technologies students, as well as for educators, professionals, and researchers in this multidisciplinary field." Professor George Kontaxakis, Universidad Politécnica de Madrid
Series Preface |
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xiii | |
Preface |
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xv | |
Editors |
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xvii | |
Contributors |
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xix | |
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SECTION I Introduction to Small Animal Imaging, Therapy, and Applications |
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Chapter 1 Defining Small Animal Imaging, Therapy, and Applications |
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3 | (4) |
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Dimitrios N. Karnabatidis |
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Chapter 2 Ethics and Regulations for Research with Animals |
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7 | (10) |
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Chapter 3 Small Animal Handling, Care, and Anesthesia |
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17 | (18) |
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Chapter 4 Preclinical Models |
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35 | (16) |
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SECTION II Small Animal Imaging: Ionizing Radiation |
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Chapter 5 Microcomputed Tomography |
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51 | (16) |
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Chapter 6 Digital Subtracted Angiography of Small Animals |
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67 | (10) |
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Dimitrios N. Karnabatidis |
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Chapter 7 Single-Photon Emission Computed Tomography |
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77 | (22) |
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Chapter 8 Positron Emission Tomography |
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99 | (22) |
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SECTION III Small Animal Imaging: Nonionizing Radiation |
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121 | (20) |
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Chapter 10 Optical Imaging |
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141 | (26) |
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SECTION IV Hybrid Imaging |
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Chapter 11 Optical-CT Imaging |
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167 | (20) |
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187 | (18) |
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Chapter 13 Introduction to Combining MRI with PET |
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205 | (28) |
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Chapter 14 Exotic Imaging Approaches |
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233 | (16) |
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Chapter 15 X-Ray, MRI, and Ultrasound Agents: Basic Principles |
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249 | (28) |
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Chapter 16 Radiochemistry for Preclinical Imaging Studies |
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277 | (38) |
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Chapter 17 Molecular Targets and Optical Probes |
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315 | (14) |
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SECTION VI Therapeutic Research Platforms |
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Chapter 18 Developing Technologies for Small Animal Radiotherapy |
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329 | (24) |
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Chapter 19 Dosimetry of Ionizing Radiation in Small Animal Imaging |
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353 | (12) |
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Chapter 20 Treatment Planning for Small Animals |
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365 | (20) |
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Chapter 21 Radiolabeled Agents for Molecular Imaging and/or Therapy |
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385 | (24) |
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SECTION VII Image Quantification |
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Chapter 22 Quantification in Nuclear Preclinical Imaging |
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409 | (14) |
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Chapter 23 Performance Assessment of Small Animal Imaging Systems and Common Standards |
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423 | (12) |
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Chapter 24 Monte Carlo Simulations in Imaging and Therapy |
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435 | (18) |
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Panagiotis Papadimitroulas |
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SECTION VIII Applications |
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Chapter 25 Small Animal Imaging and Therapy: How They Affect Patient Care |
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453 | (10) |
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Chapter 26 Applications for Drug Development |
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463 | (24) |
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Chapter 27 Imaging of Intracellular Targets |
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487 | (22) |
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Chapter 28 Imaging of Cell Trafficking and Cell Tissue Homing |
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509 | (18) |
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Chapter 29 Imaging of Cardiovascular Disease |
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527 | (22) |
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Chapter 30 Imaging Angiogenesis |
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549 | (20) |
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Chapter 31 Imaging of Hypoxia, Apoptosis, and Inflammation |
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569 | (10) |
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Athanasios Diamantopoulos |
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Chapter 32 Vessel Wall Imaging |
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579 | (10) |
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Index |
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589 | |
George C. Kagadis, PhD, FAAPM, is an associate professor of medical physics and medical informatics at the University of Patras. He also holds an adjunct assistant professor appointment at the University of Texas MD Anderson Cancer Center. He is a Greek State Scholarship Foundation grantee, a Fulbright research scholar, and a fellow of the American Association of Physicists in Medicine (AAPM). He has authored about 80 journal papers and presented at more than 20 conferences. He received his PhD in medical physics from the University of Patras. His current research interests focus on medical image processing and analysis, studies in molecular imaging, IHE, and CAD applications.
Nancy L. Ford, PhD, is an assistant professor in the Department of Oral, Biological and Medical Sciences and the director of the Centre for High-Throughput Phenogenomics at the University of British Columbia. She is a full member of the AAPM and an associate editor of Medical Physics. She publishes in journals on medical physics, radiology, and dental science. She received her PhD in medical biophysics from the University of Western Ontario. Her research focuses on preclinical micro-computed tomography imaging and image-based analysis, primarily studying models of respiratory diseases, along with CBCT and MSCT for medical and dental applications.
Dimitrios N. Karnabatidis, PhD, EBIR, is an associate professor of interventional radiology at the University of Patras. He is a fellow of the Cardiovascular and Interventional Radiological Society of Europe and a member of the Hellenic Radiology Society, the Hellenic Society of Interventional Radiology, and the Western Greece Radiology Society. He has been involved as a participant/principal investigator in several national/international research projects and has published 122 articles in peer-reviewed journals. He received his PhD from the School of Medicine, University of Patras. His research interests include angiogenesis in malignant and benign diseases, the augmentation of arteriogenesis in critical limb ischemia, endothelial hyperplasia inhibition after endovascular procedures, and ureteral obstructive diseases.
George K. Loudos, PhD, is an assistant professor in the Department of Biomedical Engineering at the Technological Educational Institute of Athens. He has published 89 articles in international journals and more than 200 papers in conference proceedings. He received his PhD in biomedical engineering from the National Technical University of Athens. His research interests focus on molecular imaging using nuclear medicine techniques and medical instrumentation. He strongly supports interdisciplinary cooperation and education in the field of nanomedicine and molecular imaging.