This edited volume explores current research and future developments in transplantation medicine. Key sections include advances in organ preservation, mechanical circulatory support, and emerging fields such as organ transplantation from cardiac death donors (DCD), pediatric application of ventricular assist device (VAD), immunological tolerance and xenotransplantation. With contributions from leading U.S. experts in pediatric VAD therapy, DCD heart and lung transplantations, combined heart and kidney transplantation, the book provides a forward-looking perspective on how these innovations will transform the field. The book also details the historical journey of organ transplantation in Japan, from its early challenges to the significant revival of heart transplantation in 1999. It presents the impressive clinical results achieved at the First Department of Surgery at Osaka University Medical School.
Heart and lung transplantation: Historical Developments, Clinical Achievements, and Future Perspectives is essential reading for medical professionals, researchers, and students interested in the latest advances and future directions in organ transplantation.
Part 1 Historical Review.
Chapter 1 Heart and lung transplantation in
Japan: How prepared and what to do now.- Part 2 Organ Preservation.
Chapter
2 Heart preservation: Myocardial protection, Cardioplegic arrest, Controlled
reperfusion, and Transplantation.
Chapter 3 Lung Preservation: Cold static
preservation solutions for lung transplantation.- Part 3 Mechanical
Circulatory Support.
Chapter 4 Mechanical circulatory support in advanced
heart failure: Acute support, Ventricular assist device, Bridge to
transplantation, and Bridge to recovery.
Chapter 5 Role of implantable
ventricular assist device in end-stage heart failure: bridge to
transplantation and destination therapy.
Chapter 6 Destination therapy:
Background and future prospects.- Part 4 Clinical achievements in heart and
lung transplantation.
Chapter 7 Pioneering Heart Transplantation in Japan: A
25-Year Journey at Osaka University.
Chapter 8 Lung Transplantation at Osaka
University.
Chapter 9: Combined heart and lung transplantation: Report of
three cases.
Chapter 10 Heart Transplantation in National Cerebral and
Cardiovascular Center.
Chapter 11 Surgical Considerations in Heart
Transplantation: Technical view point.- Part V Medical management of heart
failure update.
Chapter 12 Therapeutic Strategies for Advanced Heart Failure
Related to Heart Transplantation.
Chapter 13 Medical and Surgical Management
of Adult Congenital Heart Disease.
Chapter 14 Social Reintegration in
Survivors of Pediatric Heart Transplantation.- Part 6 Future Perspectives.-
Chapter 15 Pediatric Heart Failure Management with Ventricular Assist Device
and Heart Transplantation.
Chapter 16: Ventricular Assist Device for
Children: State of the Art and Future Directions.
Chapter 17 Lung Donation
after Circulatory Death: Current Challenges and Opportunities in United
States.
Chapter 18 Advancing Donor Lung Preservation and Repair: The Role of
Machine Perfusion in Modern Lung Transplantation.
Chapter 19 Marginal donors
in heart transplantation: Development of a risk score formula for primary
graft failure.
Chapter 20 Exploring advancements in DCD heart
transplantation: Preservation techniques, ethical challenges, and clinical
Outcomes.
Chapter 21 Multi-Organ Transplantation in the United States.-
Chapter 22 Transplantation Immunology in Lung.
Chapter 23 Immunological
Transplantation Tolerance-Availability of rat transplant models for clinical
application.
Chapter 24 Aiming for the clinical application of
xenotransplantation.
H. Matsuda served as the Professor and Chairman of the First Surgery Department of Osaka University School of Medicine from 1991 to 2005 succeeding Professor Yasunaru Kawashima (giving a Foreword to this book), and was a leading figure in cardiac surgery and opinion leader in organ transplantation in Japan. He started his career from pediatric cardiac surgery for complex heart disease, with research for myocardial protection, mechanical circulatory support, his team performed the first case of heart and lung transplantations from brain death donors in 1999 and 2000, contributing to the following smooth introduction of the organ transplantation from brain-dead donor in Japan. After retirement he has kept working to popularize organ transplantation, making a significant contribution to the current establishment of organ transplantation and mechanical circulatory support in Japan. The team has been keeping the leading position in these fields, with current Professor Yasushi Shintani of General Thoracic Surgery and Professor Shigeru Miyagawa of Cardiovascular Surgery, both are contributing as co-editors.
Dr. S. Miyagawa graduated from Osaka University Medical School in 1994 and started his career as a cardiac surgeon at the First Department of Surgery (Professor H. Matsuda).After completing his residency program, he joined the research group of Dr. Y. Sawa (Professor from 2006 to 2020) in the field of regenerative medicine for heart failure and obtained his Ph.D. degree. In 2006, he moved to Germany and joined the research group at the Max Plank Institute and also worked as a visiting surgeon at the Kenhoff Hospital in Bad Nauheim until 2009. He returned to Osaka University and started the iPS research focusing on cell sheet therapy for advanced heart failure, establishing the clinical trial in 2020. In 2021, he was appointed as Professor and Chairman of the Department of Cardiovascular Surgery of Osaka University Graduate School of Medicine, and now he is the key leader in heart transplantation in Japan and also in regenerative therapy for heart failure as well known internationally. Currently, he is working on destination therapy by durable ventricular assist device and also to start heart transplantation from donor of circulatory death.
Dr. Yasushi Shintani graduated from Osaka University in 1995 and began his career in general thoracic surgery at the former First Department of Surgery. In 2004, he earned his Ph.D. for research on the mechanisms of lung cancer metastasis. He then spent over three years conducting research at the Eppley Cancer Center, University of Nebraska Medical Center (NE, USA), where he focused on the tumor microenvironment. After over 10 years period working as a main faculty member of General Thoracic Surgery at Osaka University, Dr. Shintani was appointed to the Professor and Chief in April 2019. Until now, he performs surgical procedures for a wide range of respiratory diseases, including lung cancer, emphysematous pulmonary diseases, myasthenia gravis, mediastinal tumors, pneumothorax, and empyema. His department serves as a designated center for pulmonary transplantation. In the field of lung transplantation, he has led numerous pioneering efforts in Japan, including the first brain-dead lung transplant. His team has performed 83 brain-dead lung transplants, 11 living-donor lobar lung transplants, and 3 combined heart-lung transplants. Recently, his research has expanded to include organ preservation using ex vivo lung perfusion, elucidation of chronic lung allograft dysfunction (CLAD) mechanisms, and donation after circulatory death (DCD) lung transplantation.
