Foreword |
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ix | |
Preface |
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xi | |
Acknowledgments |
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xii | |
About the Editors |
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xiii | |
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xv | |
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SECTION I BIOLOGY OF IMMUNE CELLS |
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1 B Cells in Aging, Age-Associated Diseases and Stem Cell Transplantation |
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1 | (9) |
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2 T Cell Biology: Changes with Disease, Aging, and Hematopoietic Stem Cell Transplantation |
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10 | (9) |
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3 Plasma Cells in Autoimmunity |
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19 | (7) |
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4 Car T Cells for Autoimmunity |
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26 | (7) |
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5 Regulatory T Cells for the Treatment of Autoimmune Diseases |
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33 | (14) |
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Margarita Dominguez-Villar |
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6 Mesenchymal Stromal Cell-Derived Extracellular Vesicles |
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47 | (11) |
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SECTION II BIOLOGY OF STEM CELLS |
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7 Induced Pluripotent Stem Cells: The Story of Genetic Reprogramming |
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58 | (11) |
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8 Mesenchymal Stromal Cell Biology and Clinical Application |
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69 | (9) |
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9 Neural Stem Cell Biology |
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78 | (8) |
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10 Hematopoietic Stem Cells: Hierarchical versus Continuum |
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86 | (6) |
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11 Biology of Umbilical Cord Blood Cells |
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92 | (10) |
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SECTION III REGULATORY REQUIREMENTS |
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12 Quality, Accreditation, and Regulation in Hematopoietic Stem Cell Transplantation |
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102 | (8) |
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13 European Perspective on Cellular Therapy: Good Tissue Practice (GTP) versus Good Manufacturing Practice (GMP) |
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110 | (7) |
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14 GMP Facility Requirements in the United States |
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117 | (5) |
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SECTION IV MESENCHYMAL STEM CELLS FOR IMMUNE DISEASES |
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15 Mesenchymal Stromal Cell Therapy for Acute Graft versus Host Disease---From Bench to Clinical Approval |
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122 | (8) |
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16 Adipose-Derived Stem Cells for Systemic Sclerosis Digital Ulcers |
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130 | (8) |
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17 Musculoskeletal Stromal/Progenitor Cell-Based Cell Therapy for Rheumatoid Arthritis (RA): MSC for Cell Therapy in R A |
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138 | (9) |
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18 Mesenchymal Stromal Cells for Systemic Sclerosis |
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147 | (7) |
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19 Mesenchymal Stem Cells (MSC) for Systemic Lupus Erythematosus (SLE) |
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154 | (9) |
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20 Mesenchymal Stem/Stromal Cells for Multiple Sclerosis and Other Neurological Diseases |
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163 | (8) |
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21 Mesenchymal Stromal Cells for Perianal Fistulizing Crohn's Disease |
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171 | (11) |
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22 Umbilical Cord Blood or Mesenchymal Stromal Cells as Potential Therapies for Autism Spectrum Disorder |
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182 | (7) |
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SECTION V GENERAL CONCEPTS-HSCT FOR AUTOIMMUNE DISEASES |
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23 Animal Models of Bone Marrow Transplantation for Autoimmune Diseases |
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189 | (15) |
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24 Autologous HSCT Conditioning Regimens for Autoimmune Diseases |
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204 | (9) |
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25 Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Autoimmune Disease |
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213 | (9) |
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26 Microbiota and Immune Response |
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222 | (7) |
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27 Infectious Complications in Patients Undergoing HSCT for Autoimmune Diseases |
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229 | (12) |
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28 Early Toxicity and Supportive Care of HSCT for Autoimmune Diseases |
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241 | (11) |
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29 Late Toxicity and Supportive Care of Patients Undergoing Hematopoietic Cell Transplantation for Autoimmune Diseases |
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252 | (12) |
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264 | (7) |
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31 International Registries Sites/Indications/Activity for HSCT in Autoimmune Diseases: The European Society for Blood and Marrow Transplantation (EBMT) and Center for International Blood and Marrow Transplant Research (CIBMTR) |
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271 | (11) |
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32 Hematopoietic Stem Cell Mobilization, Collection, Apheresis, Harvest Procedures |
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282 | (10) |
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SECTION VI ALLOGENEIC HSCT FOR AUTOIMMUNE DISEASE |
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33 Hematopoietic Stem Cell Donor Registries: Search Strategies and HLA Methodologies |
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292 | (8) |
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34 Allogeneic HSCT and Graft versus Host Disease (GvHD): General Principles with Reference to Autoimmune Diseases |
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300 | (10) |
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35 Hematopoietic Cell Transplantation in Monogenic Autoimmune Diseases |
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310 | (16) |
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36 Advances in the Pathogenesis and Treatment of Immune-Mediated Aplastic Anemia |
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326 | (9) |
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SECTION VII HSCT FOR AUTOIMMUNE DISEASE |
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37 Magnetic Resonance Imaging in Multiple Sclerosis |
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335 | (9) |
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344 | (11) |
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39 Disease-Modifying Therapies and Supportive Care of Multiple Sclerosis |
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355 | (14) |
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40 Autologous Hematopoietic Stem Cell Transplantation for Secondary Progressive Multiple Sclerosis |
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369 | (6) |
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41 Autologous Hematopoietic Stem Cell Transplantation for Relapsing-Remitting Multiple Sclerosis |
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375 | (11) |
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42 Immune Mechanisms of Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis |
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386 | (5) |
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43 Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Basics and Interpretation of Electrodiagnostic Testing |
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391 | (8) |
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44 Diagnosis and Differentiation of CIDP from Other Peripheral Polyneuropathies |
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399 | (7) |
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Cristina Castilla Llorente |
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45 Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
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406 | (11) |
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46 Neuromyelitis Optica: Autologous and Allogeneic HSCT for AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorders |
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417 | (10) |
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427 | (15) |
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48 The Systemic Sclerosis Heart |
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442 | (14) |
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49 Scleroderma Renal Crisis with Special Considerations for Autologous Hematopoietic Stem Cell Transplant |
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456 | (7) |
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50 Systemic Sclerosis and the Lung |
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463 | (16) |
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51 Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis |
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479 | (10) |
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52 Crohn's Disease: Incidence, Diagnosis, Standard Treatment, Prognosis, Outcome Measures |
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489 | (9) |
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53 Hematopoietic Stem Cell Transplantation an Alternative to Treat Crohn's Disease |
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498 | (11) |
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Roberto Luiz Kaiser Junior |
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54 Type 1 Diabetes Mellitus: Hematopoietic Stem Cell Transplantation for Type 1 Diabetes Mellitus |
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509 | (9) |
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55 Systemic Lupus Erythematosus: Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus (SLE) |
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518 | (8) |
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SECTION VIII HSCT FOR AUTOIMMUNE DISEASE---DEVELOPING INDICATIONS |
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56 Refractory Celiac Disease: Hematopoietic Stem Cell Transplantation for Refractory Celiac Disease Type II |
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526 | (9) |
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57 Hematopoietic Stem Cell Transplantation for Juvenile Idiopathic Arthritis |
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535 | (12) |
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58 Hematopoietic Stem Cell Transplantation for Rheumatoid Arthritis |
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547 | (10) |
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59 Hematopoietic Stem Cell Transplantation for Behcet's Syndrome |
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557 | (12) |
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60 Hematopoietic Stem Cell Transplantation and Myasthenia Gravis |
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569 | (11) |
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61 Autologous Hematopoietic Stem Cell Transplantation in Stiff Person Spectrum Disorder |
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580 | (9) |
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62 Hematopoietic Stem Cell Transplant-Based Treatment for Psychiatric Disorders |
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589 | (5) |
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63 Hematopoietic Stem Cell Transplantation for Psoriasis and Pemphigus Vulgaris |
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594 | (5) |
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SECTION IX ETHICS AND ECONOMICS |
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64 Health Economics of Autoimmune Diseases Using Multiple Sclerosis as a Model |
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599 | (5) |
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65 Is Health Care a Human Right? |
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604 | (4) |
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66 Ethics of Stem Cells and Stem Cell Transplantation for Autoimmune Diseases |
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608 | (4) |
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Appendices: Autoimmune Diseases Indices and Instruments |
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612 | (39) |
Index |
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651 | |