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E-grāmata: Hemophilia and Hemostasis

Edited by (University of North Carolina, Chapel Hill, NC, USA), Edited by (University of Texas Health Science Center at Houston, Director, Gulf States Hemophilia and Thrombophilia Center, Houston, TX, U), Edited by (University of North Carolina, Chapel Hill, NC, USA)
  • Formāts: PDF+DRM
  • Izdošanas datums: 03-Oct-2012
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9781118439319
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  • Formāts: PDF+DRM
  • Izdošanas datums: 03-Oct-2012
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9781118439319
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This revision of the 2007 edition presents a case-based approach that updates the knowledge base on hemophilia and other bleeding and clotting disorders including von Willebrand disease, acquired bleeding disorder, and thrombotic disorder. Ma (medicine/ hematology and oncology, U. of North Carolina, Chapel Hill), Roberts (emeritus, medicine and pathology/hematology and oncology, UNC), and Escobar (medicine and pediatrics, U. of Texas Health Science Center at Houston/Gulf States Hemophilia and Thrombophilia Center) present 60 new, illustrated case studies with guidelines for clinical decision-making regarding the treatment of such disorders. Contributors also discuss considerations in different types of surgery for such patients, co-morbid diagnoses, and reproductive options for carriers. Annotation ©2013 Book News, Inc., Portland, OR (booknews.com)

There is a general need amongst healthcare professionals for practical advice on the management of patients with bleeding disorders. This book is an essential resource for all those working in the fields of coagulation, hemostasis and thrombosis. It covers the major cases one might encounter in diagnosing, managing and treating hemophilia and hemostasis. It provides a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders.

The book is divided into major chapter sections depending on the type of bleeding disorder it fits into. Each chapter includes a brief overview of the disorder covering: history of the disorder; molecular basis of the disorder; class presentation; genetics; current laboratory tests and monitoring. Cases associated with each disorder are presented alongside practical questions and answers from a wide range of contributors. As practice can vary from center to center, controversial areas are clearly marked and discussed throughout.

New to this edition: coverage of the newer techniques; newer treatment modalities; new oral anticoagulants; update on hemophilia management; more on ITP and greater coverage of new cases as suggested by reviewers.

Recenzijas

Overall, this is an extremely well written book suitable for consultants, trainees and, postgraduates, and is a must for all medical college libraries.  (Indian Journal Medical Research, 1 September 2013)

This is an important book, as there are not many on the management of hemophilia and hemostasis that use a structured, case-based approach.  (Doodys, 26 July 2013)

On the whole this book is a useful tool for daily practice, particularly for those planning to work outside of a haemophilia comprehensive care centre, where regular exposure to haemophilia is limited.  (Haem Trainee, 1 April 2013)

Contributors xi
Foreword xiii
Part 1 Hemophilia A and Hemophilia B
1(118)
Section 1 General Overview
3(26)
Introduction 1 The Hemophilic Ankle: An Update
5(10)
E. Carlos Rodriguez-Merchan
Introduction 2 The Hemophilic Knee: An Update
15(14)
E. Carlos Rodriguez-Merchan
Section 2 Hemophilia with Inhibitors
29(22)
Introduction Study 1 Inhibitor Patient Requiring High Dose Therapy with rVHa as well as Sequential Therapy with FEIBA
31(4)
Alice D. Ma
Introduction Study 2 Prophylactic Therapy in a Patient with a High Titer Inhibitor
35(2)
Alice D. Ma
Introduction Study 3 Immune Tolerance Induction
37(4)
Trinh T. Nguyen
Miguel A. Escobar
Introduction Study 4 Monitoring During Immune Tolerance Induction
41(2)
Trinh T. Nguyen
Miguel A. Escobar
Introduction Study 5 Factor IX Inhibitors
43(2)
Trinh T. Nguyen
Miguel A. Escobar
Introduction Study 6 Severe Hemophilia B with High Response Inhibitor and Anaphylactic Reaction to Factor IX
45(4)
Jenny M. Splawn
Benjamin Carcamo
Miguel A. Escobar
Introduction Study 7 Inhibitor Patient and Dental Surgery
49(2)
Alice D. Ma
Section 3 Hemophilic Treatment for Procedures
51(34)
Introduction Study 8 Deep Vein Thrombosis Prophylaxis in Patients with Hemophilia A Undergoing Orthopedic Surgery
53(2)
Alice D. Ma
Introduction Study 9 Prostate Surgery and Hemophilia
55(2)
Alice D. Ma
Introduction Study 10 Mild Hemophilia and Intraocular Injections
57(2)
Alice D. Ma
Introduction Study 11 Endoscopy/Colonoscopy and Hemophilia
59(2)
Alice D. Ma
Introduction Study 12 Dialysis and Hemophilia
61(4)
Alice D. Ma
Introduction Study 13 Circumcision
65(2)
Nidra Rodriguez
Introduction Study 14 Pharmacokinetic Studies for Surgery
67(4)
Miguel A. Escobar
Introduction Study 15 Compartment Syndrome
71(4)
Miguel A. Escobar
Introduction Study 16 Successful Eradication of Factor VIII Inhibitor in Patient with Mild Hemophilia A Prior to Hemipelvectomy for Extensive Hemophilic Pseudotumor
75(4)
Matthew Foster
Alice D. Ma
Introduction Study 17 Coronary Artery Disease and Hemophilia
79(4)
Alice D. Ma
Introduction Study 18 Valve Replacement and Hemophilia
83(2)
Alice D. Ma
Section 4 Treatment for Other Conditions
85(12)
Introduction Study 19 Thyroid Biopsy and Hemophilia
87(4)
Miguel A. Escobar
Introduction Study 20 Atrial Fibrillation and Bleeding Disorders
91(2)
Alice D. Ma
Introduction Study 21 Chronic Upper Gastrointestinal Bleeding and Hemophilia
93(2)
Alice D. Ma
Introduction Study 22 Hematuria
95(2)
Nidra Rodriguez
Section 5 Other Issues in Hemophilia Care
97(8)
Introduction Study 23 Reproductive Options for Hemophilia A Carriers
99(4)
Kristy Lee
Introduction Study 24 Mild Hemophilia A with Discrepant FVIII Activity Levels
103(2)
Alice D. Ma
Section 6 Compound Diagnoses
105(14)
Introduction Study 25 Hemophilia A with Tuberous Sclerosis and CNS Bleed
107(2)
Alice D. Ma
Introduction Study 26 Familial Risk Assessment for Individuals with Hemophilia A and von Willebrand Disease
109(4)
Kristy Lee
Introduction Study 27 Hemophilia A and Hereditary Hemorrhagic Telangiectasia
113(6)
Raj Sundar Kasthuri
Part 2 von Willebrand Disease
119(26)
Section 1 Management during Procedures
121(14)
Introduction Study 28 Type 1 von Willebrand Disease and Tonsillectomy
123(2)
Trinh T. Nguyen
Miguel A. Escobar
Introduction Study 29 von Willebrand Disease and Dental Surgery
125(4)
Trinh T. Nguyen
Miguel A. Escobar
Introduction Study 30 von Willebrand Disease and Gastrointestinal Surgery
129(6)
Marshall Mazepa
Alice D. Ma
Gynecologic and Obstetric Considerations: von Willebrand Disease and Obstetric/Gynecologic Procedures
132(3)
Alice D. Ma
Section 2 Rare Forms of von Willebrand Disease
135(10)
Introduction Study 31 Type 2A von Willebrand Disease and Recurrent Gastrointestinal Bleeding
137(2)
Alice D. Ma
Introduction Study 32 Type 2B von Willebrand Disease and Thoracic Surgery
139(2)
Alice D. Ma
Introduction Study 33 von Willebrand Disease 2N
141(4)
Tzu-Fei Wang
Alice D. Ma
Part 3 Other Bleeding Disorders
145(24)
Introduction Study 34 Prothrombin Deficiency
147(2)
Alice D. Ma
Introduction Study 35 Factor V Deficiency
149(2)
Miguel A. Escobar
Introduction Study 36 Factor VII Deficiency
151(2)
Trinh T. Nguyen
Miguel A. Escobar
Introduction Study 37 Factor X Deficiency
153(2)
Alice D. Ma
Introduction Study 38 Factor XI Deficiency
155(2)
Trinh T. Nguyen
Miguel A. Escobar
Introduction Study 39 Factor XIII Deficiency
157(2)
Alice D. Ma
Introduction Study 40 Combined Factor V and Factor VIII Deficiency
159(4)
Tyler Buckner
Alice D. Ma
Introduction Study 41 Glanzmann Thrombaesthenia
163(2)
Alice D. Ma
Introduction Study 42 Gardner-Diamond Syndrome and von Willebrand Disease
165(2)
Tzu-Fei Wang
Alice D. Ma
Introduction Study 43 Qualitative Platelet Disorder
167(2)
Trinh T. Nguyen
Miguel A. Escobar
Part 4 Acquired Bleeding Disorders
169(28)
Introduction Study 44 Acquired FVIII Inhibitor and B Cell Neoplasm
171(2)
Alice D. Ma
Introduction Study 45 FVIII Inhibitor and Lupus Inhibitor
173(2)
Alice D. Ma
Introduction Study 46 Acquired von Willebrand Disease
175(6)
Alice D. Ma
Introduction Study 47 A Woman with Bleeding Gums
181(2)
Alice D. Ma
Introduction Study 48 Bleeding after Cardiac Surgery
183(4)
Alice D. Ma
Introduction Study 49 Bleeding in a Dialysis Patient
187(2)
Alice D. Ma
Introduction Study 50 A Woman with Anemia and Hematuria
189(2)
Alice D. Ma
Introduction Study 51 Scalp Bleeding in an Older Gentleman
191(2)
Alice D. Ma
Introduction Study 52 Hyperfibrinolysis
193(4)
Miguel A. Escobar
Anas Alrwas
Part 5 Thrombotic Disorders
197(22)
Introduction Study 53 Heparin-Induced Thrombocytopenia with Thrombosis
199(4)
Miguel A. Escobar
Introduction Study 54 Heparin Skin Necrosis
203(2)
Miguel A. Escobar
Introduction Study 55 Warfarin Skin Necrosis
205(2)
Miguel A. Escobar
Introduction Study 56 Thoracic Outlet Syndrome
207(2)
Tyler Buckner
Introduction Study 57 Antithrombin Deficiency
209(2)
Miguel A. Escobar
Introduction Study 58 May-Thurner Syndrome
211(4)
Trinh T. Nguyen
Miguel A. Escobar
Introduction Study 59 Thrombosis in a Liver Transplant Patient
215(2)
Alice D. Ma
Introduction Study 60 Combined Thrombophilia
217(2)
Trinh T. Nguyen
Miguel A. Escobar
Index 219
Alice D. Ma, University of North Carolina, Chapel Hill, NC, USA.

Miguel A. Escobar, University of Texas Health Science Center at Houston, Director, Gulf States Hemophilia and Thrombophilia Center, Houston, TX, USA.



Harold Roberts, MD, ex-Senior Associate Editor of the Journal of Thrombosis and Hemostasis and Chairman, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill North Carolina, USA. Dr Roberts, a Sarah Graham Kenan Professor of Medicine and Pathology at the UNC-Chapel Hill School of Medicine, earned his undergraduate and medical degrees from UNC-Chapel Hill, joined the faculty in 1962 and has served as Chief of the Division of Hematology and Director of the UNC-Chapel Hill Comprehensive Hemophilia Diagnostic and Treatment Center. He was also the Founding Director of the school's Center for Thrombosis and Hemostasis, which conducts research on blood clotting disorders related to cardiovascular disease and on bleeding disorders such as hemophilia. He has served on the editorial boards of Current Opinion in Hematology and Hematologic Pathology, as well as being Senior Associate Editor of Thrombosis and Hemostasis. Excellence in laboratory research and patient care has earned Dr. Roberts numerous awards: the French International Prize for Research on Hemophilia, the National Hemophilia Foundation's Kenneth M. Brinkhous Award for Excellence in Clinical Research, and the Robert P. Grant Medal, the highest honor given by the International Society on Thrombosis and Hemostasis. The citation accompanying this award lauded him as "one of the pioneers in the field of coagulation as well as being a leader in the Chapel Hill group which has brought so much to our present understanding of the subtleties in the mechanisms of coagulation. His contributions to our field have had a major impact, especially his outstanding work on the genetic basis of hemophilia." In spring of 2000, Dr. Roberts received the UNC Medical Alumni Association's Distinguished Faculty Award and an honorary Doctor of Medicine degree from Lund University in Sweden.