Preface |
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vi | |
Acknowledgments |
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vii | |
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1 | (27) |
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Overview of Methods Used in Histology |
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1 | (1) |
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2 | (1) |
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Histochemistry and Cytochemistry |
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3 | (9) |
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12 | (14) |
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Folder 1.1 Clinical Correlation: Frozen Sections |
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4 | (3) |
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Folder 1.2 Functional Considerations: Feulgen Microspectrophotometry |
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7 | (2) |
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Folder 1.3 Clinical Correlation: Monoclonal Antibodies in Medicine |
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9 | (8) |
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Folder 1.4 Functional Considerations: Proper Use of the Light Microscope |
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17 | (9) |
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26 | (2) |
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28 | (54) |
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Overview of the Cell and Cytoplasm |
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28 | (3) |
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31 | (31) |
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62 | (15) |
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77 | (2) |
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79 | (1) |
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Folder 2.1 Clinical Correlation: Lysosomal Storage Diseases |
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48 | (28) |
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Folder 2.2 Clinical Correlation: Abnormalities in Microtubules and Filaments |
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76 | (3) |
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Folder 2.3 Clinical Correlation: Abnormal Duplication of Centrioles and Cancer |
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79 | (1) |
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80 | (2) |
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82 | (24) |
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82 | (1) |
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82 | (10) |
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92 | (1) |
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92 | (7) |
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99 | (5) |
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Folder 3.1 Clinical Correlation: Cytogenetic Testing |
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87 | (1) |
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Folder 3.2 Clinical Correlation: Regulation of Cell Cycle and Cancer Treatment |
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88 | (16) |
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104 | (2) |
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4 Tissues: Concept and Classification |
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106 | (10) |
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106 | (1) |
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107 | (1) |
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108 | (1) |
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108 | (1) |
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109 | (1) |
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110 | (3) |
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113 | (1) |
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Folder 4.1 Clinical Correlation: Ovarian Teratomas |
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112 | (2) |
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114 | (2) |
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116 | (54) |
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Overview of Epithelial Structure and Function |
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116 | (1) |
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Classification of Epithelium |
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117 | (1) |
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118 | (2) |
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The Apical Domain and its Modifications |
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120 | (13) |
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The Lateral Domain and its Specializations in Cell-to-Cell Adhesion |
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133 | (14) |
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The Basal Domain and its Specializations in Cell-to-Extracellular Matrix Adhesion |
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147 | (10) |
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157 | (3) |
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160 | (2) |
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Folder 5.1 Clinical Correlation: Epithelial Metaplasia |
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120 | (13) |
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Folder 5.2 Clinical Correlation: Primary Ciliary Dyskinesia (Immotile Cilia Syndrome) |
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133 | (9) |
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Folder 5.3 Clinical Correlation: Junctional Complexes as a Target of Pathogenic Agents |
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142 | (8) |
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Folder 5.4 Functional Considerations: Basement Membrane and Basal Lamina Terminology |
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150 | (11) |
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Folder 5.5 Functional Considerations: Mucous and Serous Membranes |
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161 | (1) |
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162 | (2) |
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Plate 1 Simple Squamous and Cuboidal Epithelia |
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164 | (2) |
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Plate 2 Simple and Stratified Epithelia |
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166 | (2) |
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Plate 3 Stratified Epithelia and Epithelioid Tissues |
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168 | (2) |
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170 | (40) |
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Overview of Connective Tissue |
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170 | (1) |
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Embryonic Connective Tissue |
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170 | (2) |
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172 | (2) |
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174 | (12) |
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186 | (4) |
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190 | (12) |
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Folder 6.1 Clinical Correlation: Collagenopathies |
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181 | (5) |
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Folder 6.2 Clinical Correlation: Sun Exposure and Molecular Changes in Photoaged Skin |
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186 | (10) |
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Folder 6.3 Clinical Correlation: Role of Myofibroblasts in Wound Repair |
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196 | (1) |
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Folder 6.4 Functional Considerations: The Mononuclear Phagocyte System |
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197 | (1) |
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Folder 6.5 Clinical Correlation: The Role of Mast Cells and Basophils in Allergic Reactions |
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198 | (4) |
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202 | (2) |
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Plate 4 Loose and Dense Irregular Connective Tissue |
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204 | (2) |
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Plate 5 Dense Regular Connective Tissue, Tendons, and Ligaments |
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206 | (2) |
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Plate 6 Elastic Fibers and Elastic Lamellae |
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208 | (2) |
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210 | (22) |
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210 | (1) |
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210 | (7) |
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217 | (1) |
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217 | (1) |
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Chondrogenesis and Cartilage Growth |
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218 | (1) |
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Repair of Hyaline Cartilage |
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219 | (3) |
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Folder 7.1 Clinical Correlation: Osteoarthritis |
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211 | (9) |
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Folder 7.2 Clinical Correlation: Malignant Tumors of the Cartilage: Chondrosarcomas |
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220 | (2) |
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222 | (2) |
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Plate 7 Hyaline Cartilage |
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224 | (2) |
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Plate 8 Hyaline Cartilage and the Developing Skeleton |
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226 | (2) |
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Plate 9 Elastic Cartilage |
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228 | (2) |
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230 | (2) |
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232 | (42) |
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232 | (1) |
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General Structure of Bones |
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233 | (2) |
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235 | (2) |
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237 | (9) |
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246 | (7) |
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Biologic Mineralization and Matrix Vesicles |
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253 | (2) |
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Bone as Atarget of Endocrine Hormones and as an Endocrine Organ |
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255 | (3) |
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258 | (4) |
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Folder 8.1 Clinical Correlation: Joint Diseases |
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235 | (21) |
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Folder 8.2 Clinical Correlation: Osteoporosis |
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256 | (2) |
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Folder 8.3 Clinical Correlation: Nutritional Factors in Bone Formation |
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258 | (1) |
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Folder 8.4 Functional Considerations: Hormonal Regulation of Bone Growth |
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259 | (3) |
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262 | (2) |
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Plate 11 Bone, Ground Section |
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264 | (2) |
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Plate 12 Bone and Bone Tissue |
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266 | (2) |
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Plate 13 Endochondral Bone Formation I |
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268 | (2) |
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Plate 14 Endochondral Bone Formation II |
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270 | (2) |
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Plate 15 Intramembranous Bone Formation |
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272 | (2) |
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274 | (14) |
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Overview of Adipose Tissue |
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274 | (1) |
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274 | (5) |
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279 | (5) |
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Transdifferentiation of Adiposetissue |
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284 | (2) |
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Folder 9.1 Clinical Correlation: Obesity |
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281 | (2) |
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Folder 9.2 Clinical Correlation: Adipose Tissue Tumors |
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283 | (2) |
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Folder 9.3 Clinical Correlation: PET Scanning and Brown Adipose Tissue Interference |
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285 | (1) |
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286 | (2) |
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288 | (2) |
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290 | (46) |
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290 | (1) |
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291 | (2) |
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293 | (4) |
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297 | (12) |
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309 | (3) |
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312 | (1) |
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Formation of Blood Cells (Hemopoiesis) |
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313 | (10) |
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323 | (3) |
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Folder 10.1 Clinical Correlation: ABO and Rh Blood Group Systems |
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295 | (2) |
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Folder 10.2 Clinical Correlation: Hemoglobin in Patients with Diabetes |
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297 | (1) |
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Folder 10.3 Clinical Correlation: Hemoglobin Disorders |
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298 | (5) |
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Folder 10.4 Clinical Correlation: Inherited Disorders of Neutrophils; Chronic Granulomatous Disease |
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303 | (2) |
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Folder 10.5 Clinical Correlation: Hemoglobin Breakdown and Jaundice |
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305 | (19) |
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Folder 10.6 Clinical Correlation: Cellularity of the Bone Marrow |
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324 | (2) |
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326 | (2) |
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Plate 17 Erythrocytes and Granulocytes |
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328 | (2) |
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Plate 18 Agranulocytes and Red Marrow |
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330 | (2) |
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332 | (2) |
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334 | (2) |
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336 | (96) |
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Overview and Classification of Muscle |
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336 | (1) |
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337 | (17) |
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354 | (4) |
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358 | (8) |
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Folder 11.1 Functional Considerations: Muscle Metabolism and Ischemia |
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342 | (3) |
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Folder 11.2 Clinical Correlation: Muscular Dystrophies---Dystrophin and Dystrophin-Associated Proteins |
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345 | (5) |
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Folder 11.3 Clinical Correlation: Myasthenia Gravis |
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350 | (14) |
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Folder 11.4 Functional Considerations: Comparison of the Three Muscle Types |
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364 | (2) |
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366 | (2) |
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Plate 21 Skeletal Muscle I |
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368 | (2) |
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Plate 22 Skeletal Muscle II and Electron Microscopy |
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370 | (2) |
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Plate 23 Myotendinous Junction |
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372 | (2) |
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374 | (2) |
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Plate 25 Cardiac Muscle, Purkinje Fibers |
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376 | (2) |
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378 | (2) |
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Overview of the Nervous System |
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380 | (1) |
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Composition of Nerve Tissue |
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381 | (1) |
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381 | (14) |
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Supporting Cells of the Nervous System: The Neuroglia |
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395 | (10) |
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Origin of Nerve Tissue Cells |
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405 | (1) |
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Organization of the Peripheral Nervous System |
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406 | (2) |
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Organization of the Autonomic Nervous System |
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408 | (4) |
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Organization of the Central Nervous System |
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412 | (4) |
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Response of Neurons to Injury |
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416 | (4) |
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Folder 12.1 Clinical Correlation: Parkinson Disease |
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390 | (7) |
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Folder 12.2 Clinical Correlation: Demyelinating Diseases |
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397 | (22) |
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Folder 12.3 Clinical Correlation: Reactive Gliosis: Scar Formation in the Central Nervous System |
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419 | (1) |
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420 | (2) |
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Plate 27 Sympathetic and Dorsal Root Ganglia |
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422 | (2) |
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Plate 28 Peripheral Nerve |
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424 | (2) |
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426 | (2) |
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428 | (2) |
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430 | (2) |
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432 | (40) |
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Overview of the Cardiovascular System |
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432 | (1) |
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433 | (7) |
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General Features of Arteries and Veins |
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440 | (7) |
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447 | (5) |
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452 | (3) |
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455 | (1) |
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455 | (3) |
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458 | (1) |
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459 | (3) |
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Folder 13.1 Clinical Correlation: Atherosclerosis |
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442 | (6) |
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Folder 13.2 Clinical Correlation: Hypertension |
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448 | (12) |
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Folder 13.3 Clinical Correlation: Coronary Heart Disease |
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460 | (2) |
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462 | (2) |
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464 | (2) |
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466 | (2) |
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Plate 34 Muscular Arteries and Medium Veins |
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468 | (2) |
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Plate 35 Arterioles, Venules, and Lymphatic Vessels |
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470 | (2) |
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14 Immune System and Lymphatic Tissues and Organs |
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472 | (52) |
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Overview of the Immune and Lymphatic Systems |
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472 | (2) |
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Cells of the Immune System |
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474 | (14) |
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Lymphatic Tissues and Organs |
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488 | (22) |
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Folder 14.1 Functional Considerations: Origin of the Names T Lymphocyte and B Lymphocyte |
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479 | (1) |
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Folder 14.2 Clinical Correlation: Hypersensitivity Reactions |
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480 | (11) |
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Folder 14.3 Clinical Correlation: Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) |
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491 | (14) |
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Folder 14.4 Clinical Correlation: Reactive (Inflammatory) Lymphadenitis |
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505 | (5) |
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510 | (2) |
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512 | (2) |
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514 | (2) |
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516 | (2) |
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518 | (2) |
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520 | (2) |
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522 | (2) |
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524 | (42) |
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Overview of the Integumentary System |
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524 | (1) |
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525 | (4) |
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529 | (7) |
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536 | (16) |
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Folder 15.1 Clinical Correlation: Cancers of Epidermal Origin |
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527 | (10) |
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Folder 15.2 Clinical Correlation: Mohs Micrographic Surgery |
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537 | (6) |
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Folder 15.3 Functional Considerations: Skin Color |
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543 | (1) |
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Folder 15.4 Functional Considerations: Hair Growth and Hair Characteristics |
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544 | (1) |
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Folder 15.5 Clinical Correlation: Sweating and Disease |
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544 | (6) |
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Folder 15.6 Clinical Correlation: Skin Repair |
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550 | (2) |
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552 | (2) |
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554 | (2) |
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556 | (2) |
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Plate 44 Apocrine and Eccrine Sweat Glands |
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558 | (2) |
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Plate 45 Sweat and Sebaceous Glands |
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560 | (2) |
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Plate 46 Integument and Sensory Organs |
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562 | (2) |
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Plate 47 Hair Follicle and Nail |
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564 | (2) |
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16 Digestive System I: Oral Cavity and Associated Structures |
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566 | (42) |
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Overview of the Digestive System |
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566 | (1) |
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567 | (2) |
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569 | (4) |
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Teeth and Supporting Tissues |
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573 | (12) |
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585 | (9) |
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Folder 16.1 Clinical Correlation: The Genetic Basis of Taste |
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575 | (3) |
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Folder 16.2 Clinical Correlation: Classification of Permanent (Secondary) and Deciduous (Primary) Dentition |
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578 | (8) |
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Folder 16.3 Clinical Correlation: Dental Caries |
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586 | (6) |
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Folder 16.4 Clinical Correlation: Salivary Gland Tumors |
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592 | (2) |
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594 | (2) |
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Plate 48 Lip and Mucocutaneous Junction |
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596 | (2) |
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598 | (2) |
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Plate 50 Tongue II-Foliate Papillae and Taste Buds |
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600 | (2) |
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Plate 51 Submandibular Gland |
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602 | (2) |
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604 | (2) |
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Plate 53 Sublingual Gland |
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606 | (2) |
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17 Digestive System II: Esophagus and Gastrointestinal Tract |
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608 | (58) |
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Overview of the Esophagus and Gastrointestinal Tract |
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608 | (3) |
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611 | (2) |
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613 | (13) |
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626 | (9) |
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635 | (7) |
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Folder 17.1 Clinical Correlation: Pernicious Anemia and Peptic Ulcer Disease |
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617 | (1) |
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Folder 17.2 Clinical Correlation: Zollinger-Ellison Syndrome |
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618 | (1) |
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Folder 17.3 Functional Considerations: The Gastrointestinal Endocrine System |
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619 | (5) |
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Folder 17.4 Functional Considerations: Digestive and Absorptive Functions of Enterocytes |
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624 | (9) |
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Folder 17.5 Functional Considerations: Immune Functions of the Alimentary Canal |
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633 | (6) |
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Folder 17.6 Clinical Correlation: The Pattern of Lymph Vessel Distribution and Diseases of the Large Intestine |
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639 | (2) |
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Folder 17.7 Clinical Correlation: Colorectal Cancer |
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641 | (1) |
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642 | (2) |
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644 | (2) |
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Plate 55 Esophagus and Stomach, Cardiac Region |
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646 | (2) |
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648 | (2) |
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650 | (2) |
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Plate 58 Gastroduodenal Junction |
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652 | (2) |
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654 | (2) |
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656 | (2) |
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658 | (2) |
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660 | (2) |
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662 | (2) |
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664 | (2) |
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18 Digestive System III: Liver, Gallbladder, and Pancreas |
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666 | (36) |
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666 | (14) |
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680 | (3) |
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683 | (9) |
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Folder 18.1 Clinical Correlation: Lipoproteins |
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668 | (6) |
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Folder 18.2 Clinical Correlation: Congestive Heart Failure, Acetaminophen Overdose, and Liver Necrosis |
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674 | (16) |
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Folder 18.3 Clinical Correlation: Insulin Production and Alzheimer Disease |
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690 | (1) |
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Folder 18.4 Functional Considerations: Insulin Synthesis, an Example of Posttranslational Processing |
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691 | (1) |
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692 | (2) |
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694 | (2) |
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696 | (2) |
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698 | (2) |
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700 | (2) |
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702 | (38) |
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Overview of the Respiratory System |
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702 | (1) |
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703 | (5) |
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708 | (1) |
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708 | (2) |
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710 | (5) |
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715 | (1) |
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716 | (3) |
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719 | (5) |
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724 | (1) |
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725 | (1) |
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725 | (3) |
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Folder 19.1 Clinical Correlation: Common Conditions Affecting the Nasal Mucosa |
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715 | (2) |
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Folder 19.2 Clinical Correlation: Squamous Metaplasia in the Respiratory Tract |
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717 | (1) |
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Folder 19.3 Clinical Correlation: Asthma |
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718 | (7) |
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Folder 19.4 Clinical Correlation: Cystic Fibrosis |
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725 | (1) |
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Folder 19.5 Clinical Correlation: Chronic Obstructive Pulmonary Disease and Pneumonia |
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726 | (2) |
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728 | (2) |
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Plate 69 Olfactory Mucosa |
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730 | (2) |
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732 | (2) |
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734 | (2) |
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Plate 72 Bronchioles and End Respiratory Passages |
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736 | (2) |
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Plate 73 Terminal Bronchiole, Respiratory Bronchiole, and Alveolus |
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738 | (2) |
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740 | (44) |
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Overview of the Urinary System |
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740 | (1) |
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General Structure of the Kidney |
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741 | (15) |
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756 | (5) |
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761 | (1) |
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Histophysiology of the Kidney |
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762 | (1) |
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763 | (2) |
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765 | (1) |
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765 | (1) |
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Ureter, Urinary Bladder, and Urethra |
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766 | (4) |
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Folder 20.1 Functional Considerations: Kidney and Vitamin D |
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741 | (13) |
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Folder 20.2 Clinical Correlation: Antiglomerular Basement Membrane Antibody-Induced Glomerulonephritis; Goodpasture Syndrome |
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754 | (1) |
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Folder 20.3 Clinical Correlation: Renin-Angiotensin-Aldosterone System and Hypertension |
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755 | (1) |
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Folder 20.4 Clinical Correlation: Examination of the Urine---Urinalysis |
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756 | (6) |
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Folder 20.5 Functional Considerations: Structure and Function of Aquaporin Water Channels |
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762 | (1) |
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Folder 20.6 Functional Considerations: Antidiuretic Hormone Regulation of Collecting Duct Function |
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763 | (7) |
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770 | (2) |
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772 | (2) |
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774 | (2) |
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776 | (2) |
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778 | (2) |
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780 | (2) |
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782 | (2) |
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784 | (48) |
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Overview of the Endocrine System |
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784 | (3) |
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Pituitary Gland (Hypophysis) |
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787 | (10) |
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797 | (1) |
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798 | (1) |
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799 | (7) |
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806 | (2) |
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808 | (10) |
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Folder 21.1 Functional Considerations: Regulation of Pituitary Gland Secretion |
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788 | (8) |
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Folder 21.2 Clinical Correlation: Principles of Endocrine Diseases |
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796 | (1) |
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Folder 21.3 Clinical Correlation: Pathologies Associated with Antidiuretic Hormone Secretion |
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796 | (9) |
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Folder 21.4 Clinical Correlation: Abnormal Thyroid Function |
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805 | (9) |
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Folder 21.5 Clinical Correlation: Chromaffin Cells and Pheochromocytoma |
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814 | (2) |
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Folder 21.6 Functional Considerations: Biosynthesis of Adrenal Hormones |
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816 | (2) |
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818 | (2) |
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820 | (2) |
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822 | (2) |
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824 | (2) |
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Plate 83 Parathyroid and Thyroid Glands |
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826 | (2) |
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828 | (2) |
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Plate 85 Adrenal Gland II |
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830 | (2) |
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22 Male Reproductive System |
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832 | (44) |
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Overview of the Male Reproductive System |
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832 | (1) |
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832 | (7) |
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839 | (6) |
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845 | (5) |
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850 | (1) |
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850 | (4) |
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854 | (1) |
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855 | (4) |
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859 | (1) |
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860 | (2) |
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Folder 22.1 Functional Considerations: Hormonal Regulation of Spermatogenesis |
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839 | (1) |
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Folder 22.2 Clinical Correlation: Factors Affecting Spermatogenesis |
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840 | (9) |
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Folder 22.3 Clinical Correlation: Sperm-Specific Antigens and the Immune Response |
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849 | (8) |
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Folder 22.4 Clinical Correlation: Benign Prostatic Hypertrophy and Cancer of the Prostate |
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857 | (3) |
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Folder 22.5 Clinical Correlation: Mechanism of Erection and Erectile Dysfunction |
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860 | (2) |
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862 | (2) |
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864 | (2) |
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866 | (2) |
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Plate 88 Efferent Ductules and Epididymis |
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868 | (2) |
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Plate 89 Spermatic Cord and Ductus Deferens |
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870 | (2) |
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872 | (2) |
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874 | (2) |
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23 Female Reproductive System |
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876 | (68) |
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Overview of the Female Reproductivesystem |
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876 | (1) |
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877 | (14) |
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891 | (2) |
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893 | (8) |
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901 | (5) |
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906 | (1) |
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907 | (2) |
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909 | (7) |
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Folder 23.1 Clinical Correlation: Polycystic Ovary Disease |
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884 | (6) |
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Folder 23.2 Clinical Correlation: In Vitro Fertilization |
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890 | (4) |
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Folder 23.3 Functional Considerations: Summary of Hormonal Regulation of the Ovarian Cycle |
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894 | (11) |
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Folder 23.4 Clinical Correlation: The Placenta |
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905 | (3) |
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Folder 23.5 Clinical Correlation: Cervical Cytology: The Pap Test |
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908 | (6) |
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Folder 23.6 Clinical Correlation: Cervical Cancer and Human Papillomavirus Infections |
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914 | (1) |
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Folder 23.7 Functional Considerations: Lactation and Infertility |
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915 | (1) |
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916 | (4) |
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920 | (2) |
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922 | (2) |
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924 | (2) |
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926 | (2) |
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928 | (2) |
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930 | (2) |
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932 | (2) |
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934 | (2) |
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936 | (2) |
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938 | (2) |
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Plate 102 Mammary Gland Inactive Stage |
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940 | (2) |
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Plate 103 Mammary Gland, Late Proliferative and Lactating Stages |
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942 | (2) |
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944 | (38) |
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944 | (1) |
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General Structure of the Eye |
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944 | (3) |
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Microscopic Structure of the Eye |
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947 | (22) |
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Accessory Structures of the Eye |
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969 | (3) |
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Folder 24.1 Clinical Correlation: Glaucoma |
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954 | (1) |
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Folder 24.2 Clinical Correlation: Retinal Detachment |
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955 | (1) |
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Folder 24.3 Clinical Correlation: Age-Related Macular Degeneration |
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956 | (5) |
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Folder 24.4 Clinical Correlation: Clinical Imaging of the Retina |
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961 | (3) |
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Folder 24.5 Clinical Correlation: Color Blindness |
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964 | (4) |
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Folder 24.6 Clinical Correlation: Conjunctivitis |
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968 | (4) |
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972 | (2) |
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974 | (2) |
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976 | (2) |
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Plate 106 Eye III: Anterior Segment |
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978 | (2) |
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Plate 107 Eye IV: Sclera, Cornea, and Lens |
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980 | (2) |
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982 | (26) |
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982 | (1) |
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982 | (1) |
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983 | (4) |
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987 | (15) |
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Folder 25.1 Clinical Correlation: Otosclerosis |
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988 | (8) |
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Folder 25.2 Clinical Correlation: Hearing Loss---Vestibular Dysfunction |
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996 | (5) |
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Folder 25.3 Clinical Correlation: Vertigo |
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1001 | (1) |
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1002 | (2) |
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1004 | (2) |
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Plate 109 Cochlear Canal and Organ of Corti |
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|
1006 | (2) |
Index |
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1008 | |