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How to Optimize Fluid Bed Processing Technology: Part of the Expertise in Pharmaceutical Process Technology Series [Mīkstie vāki]

(DPharma Group Inc, Maryland, USA)
  • Formāts: Paperback / softback, 210 pages, height x width: 229x152 mm, weight: 360 g
  • Sērija : Expertise in Pharmaceutical Process Technology
  • Izdošanas datums: 06-Apr-2017
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0128047275
  • ISBN-13: 9780128047279
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  • Cena: 69,01 €
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How to Optimize Fluid Bed Processing Technology: Part of the Expertise in Pharmaceutical Process Technology SeriesPalielināt
  • Formāts: Paperback / softback, 210 pages, height x width: 229x152 mm, weight: 360 g
  • Sērija : Expertise in Pharmaceutical Process Technology
  • Izdošanas datums: 06-Apr-2017
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0128047275
  • ISBN-13: 9780128047279
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780128047279.html
Keywords:

How to Optimize Fluid Bed Processing Technology: Part of the Expertise in Pharmaceutical Process Technology Series addresses the important components of fluid bed granulation, providing answers to problems that commonly arise and using numerous practical examples and case studies as reference.

This book covers the theoretical concepts involved in fluidization, also providing a description of the choice and functionality of equipment. Additional chapters feature key aspects of the technology, including formulation requirements, process variables, process scale-up, troubleshooting, new development, safety, and process evaluation.

Given its discussion of theoretical principles and practical solutions, this is a go-to resource for all those scientists and new researchers working with fluid bed granulation as a unit operation.

  • Written by an expert in the field with several years of experience in product development, manufacturing, plant operations, and process engineering
  • Illustrates when fluid bed granulation is needed, when to use less common fluid bed granulation methods, and the advantages of fluid bed granulation when compared to other granulation techniques
  • Offers troubleshooting tips and practical advice for scientists working with this technique

Papildus informācija

A concise overview of the fluid bed granulation process, its necessary equipment, real-world tips, and solutions to common issues
About the Expertise in Pharmaceutical Process Technology Series xi
Chapter 1 Introduction
1(6)
1.1 Introduction
1(1)
1.2 Advantages and Challenges of Fluidized Bed Granulation
2(5)
Chapter 2 Fluidization Theory
7(8)
2.1 How Does Fluidization Take Place?
7(2)
2.2 Understanding the Particles
9(1)
2.3 Types of Fluid Beds
9(3)
2.4 Controlling Gas Velocity
12(1)
2.5 Addressing Fluidization Challenges
12(2)
2.6 Summary
14(1)
References
14(1)
Chapter 3 Fluid Bed Processor Equipment and Its Functionality
15(10)
3.1 Introduction
15(1)
3.2 Questions Before Specifying the Equipment
16(2)
3.3 Fluid Bed Processor Components
18(6)
3.4 Summary
24(1)
Chapter 4 Process Development
25(12)
4.1 Process Selection
25(1)
4.2 Quality by Design
26(2)
4.3 Processing in Fluid Bed
28(2)
4.4 Risk Assessment and Management
30(1)
4.5 Process Control
31(1)
4.6 Case Study
32(2)
4.7 Summary
34(3)
Reference
36(1)
Chapter 5 Granulation
37(18)
5.1 Theory
37(1)
5.2 Binders
37(3)
5.3 Nozzles
40(5)
5.4 Process Parameters
45(1)
5.5 Challenges in Fluid Bed Granulation
46(3)
5.6 Granulation End Point
49(2)
5.7 Granulation Characterization
51(1)
5.8 Summary
52(3)
References
53(2)
Chapter 6 Drying
55(10)
6.1 Theory
55(1)
6.2 Drying Granulated Product
56(6)
6.3 Summary
62(3)
References
63(2)
Chapter 7 Coating
65(16)
7.1 Introduction
65(1)
7.2 Top-Spray Coating
65(2)
7.3 Wurster Coating
67(3)
7.4 Other Coating Modules
70(4)
7.5 Dry Powder Coating
74(1)
7.6 Problems in Coating in Fluid Bed
75(1)
7.7 Case Studies
76(1)
7.8 Characterization of the Coating
76(2)
7.9 Selection of the Process for Coating
78(1)
7.10 Summary
79(2)
References
79(2)
Chapter 8 Pelletization
81(16)
8.1 Introduction
81(1)
8.2 Pelletization With Wurster Coating Module
82(3)
8.3 Pelletization in Rotary Fluid Bed
85(6)
8.4 Case Studies
91(3)
8.5 Characterization of Pellets
94(1)
8.6 Summary
94(3)
References
95(2)
Chapter 9 Other Fluid Bed Processes and Applications
97(16)
9.1 Introduction
97(1)
9.2 Fluidized Hot Melt Granulation (FHMG)
97(4)
9.3 Spray Congealing
101(1)
9.4 Pressure Swing Granulation (PSG)
102(1)
9.5 Wurster Module for Granulation
102(2)
9.6 Foam Granulation
104(1)
9.7 Steam Granulation
104(1)
9.8 Rotary Fluid Bed Agglomeration
105(1)
9.9 Spray-Drying Granulation
106(1)
9.10 Continuous Granulation
107(6)
References
109(4)
Chapter 10 Process Control and PAT
113(14)
10.1 Background
113(1)
10.2 Process Control
113(2)
10.3 Temperature Measurement
115(1)
10.4 NIR
116(2)
10.5 Chord Length Determination (FBRM and SFV)
118(3)
10.6 The Lighthouse Probe
121(1)
10.7 Image Analysis
122(2)
10.8 Other Methods
124(1)
10.9 Summary
124(3)
References
125(2)
Chapter 11 Process Scale-Up
127(24)
11.1 Introduction
127(2)
11.2 Various Scale-Up Considerations and Approaches
129(4)
11.3 Scale-Up of Fluid Bed Granulation and Drying
133(3)
11.4 Case Studies---Granulation Scale-Up
136(5)
11.5 Fluid Bed Coating Scale-Up
141(5)
11.6 Rotary Fluid Bed Coating
146(2)
11.7 Summary
148(3)
References
148(3)
Chapter 12 Integrated Systems
151(16)
12.1 Material Handling
151(6)
12.2 Integrated Systems for Nonpotent Compounds
157(3)
12.3 Integrated Systems for Potent Compounds
160(5)
12.4 Summary
165(2)
Reference
165(2)
Chapter 13 Process Troubleshooting
167(14)
13.1 Troubleshooting the Granulation Process
167(8)
13.2 Troubleshooting the Drying Process
175(3)
13.3 Troubleshooting the Coating Process
178(2)
13.4 Summary
180(1)
References
180(1)
Chapter 14 Fluid Bed Safety
181(10)
14.1 Introduction
181(5)
14.2 Safety From Solvents
186(5)
References
189(2)
Appendix: Acknowledgments 191(2)
Index 193
Dilip M. Parikh is president of the pharmaceutical technology consulting group DPharma Group Inc. in the USA. As an industrial pharmacist, Parikh has more than 40 years of industrial experience in solid dosage technologies, cGMP complaint facility planning, process engineering and manufacturing and operational management at various major pharmaceutical companies in Canada and the U.S. Prior to starting DPharma Group, he held the position of vice president of operations and technology at Synthon Pharmaceuticals in North Carolina and vice president and general manager at Atlantic Pharmaceuticals Services in Maryland. He has authored several book chapters and articles on various pharmaceutical technologies, including quality by design, continuous manufacturing, process optimization and contract manufacturing. He has been an invited speaker at scientific conferences worldwide on solid-dosage technologies development and manufacturing.