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E-grāmata: Human Preimplantation Embryo Selection [Taylor & Francis e-book]

Edited by (Bourn Hall Clinic, Cambridge, UK), Edited by (Tyho-Galileo Research Laboratories, West Orange, NJ, USA)
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The most profound dilemma in assisted reproduction to date is the inability to recognize potentially viable embryos before their replacement into the reproductive tract. Application of increasingly advanced new technology has allowed the field of embryo evaluation to evolve rapidly and dramatically over the past five years.

Human Preimplantation Embryo Selection assembles the leaders in the field of assisted reproduction to discuss their visions of dealing with the topic of embryo selection in the light of the limitations involving the fragility of the early human embryo.

The purpose of this book is to shed light on the ever-expanding techniques that are being employed and evaluated with regard to embryo selection. A comprehensive overview may guide the ART practitioner in choice of techniques and evaluation of benefits and drawbacks.

This book will provide an up-to-date overview and reference source: an invaluable tool for assisted reproductive practice worldwide.
List of contributors
vii
Preface xi
Acknowledgments xiii
Section I: Morphology
Human oocyte and embryo assessment for ART
1(14)
A Henry Sathananthan
Sulochana Gunasheela
The zona pellucida and markers of oocyte and embryo viability
15(6)
Anette Gabrielsen
Svend Lindenberg
Morphology and kinetics of human pronuclei
21(10)
Jan Tesarik
Raquel Mendoza-Tesarik
Ermanno Greco
Carmen Mendoza
Human pronuclei as a mode of predicting viability
31(10)
Aidita N James
Multinucleation and mosaicism in the human preimplantation embryo
41(10)
Renee Walmsley
The origins and consequences of fragmentation in mammalian eggs and embryos
51(28)
Mina Alikani
Analysis of blastocyst morphology
79(10)
David K Gardner
John Stevens
Courtney B Sheehan
William B Schoolcraft
Morphometric analysis of human embryos
89(12)
Christina Hnida
Søren Ziebe
Development rate, cumulative scoring, and embryonic viability
101(22)
Christine C Skiadas
Catherine Racowsky
Human embryo cryopreservation and its effects on embryo morphology
123(12)
James J Stachecki
Klaus Wiemer
Manipulating embryo development
135(10)
Jacques Cohen
Section II: Metabolism and Immunolgoy
Assessment of soluble human leukocyte antigen G in human embryos
145(10)
Jeffrey D Fisch
Levent Keskintepe
Geoffrey Sher
Immunological aspects of embryo development
155(14)
Carol M Warner
Nitric oxide regulation of the preimplantation embryo
169(10)
Yvette M Huet-Hudson
Uptake and release of metabolites in human preimplantation embryos
179(12)
Fabienne Devreker
Preimplantation embryo metabolism and embryo interaction with the in vitro environment
191(10)
Yves J R Menezo
Pierre Guerin
Section III: Genetic Aberrations and Embryo Selection
Polar body chromosome abnormalities and their consequences for human embryo development
201(8)
Anver Kuliev
Yury Verlinsky
Chromosomal status of human embryos
209(26)
Santiago Munne
Luca Gianaroli
Genomic imprinting and consequences for embryonic development
235(10)
Henry E Malter
Selection of viable embryos and gametes by rapid, non-invasive metabolomic profiling of oxidative stress biomarkers
245(18)
James T Posillico
Gene expression analysis in the human oocyte and embryo
263(12)
Nury M Steuerwald
Mitochondria in reproduction: future assays for embryo selection
275(12)
Brian Dale
Loredana Di Matteo
Martin Wilding
Future genetic and other technologies for assessing embryos
287(14)
Dagan Wells
Section IV: Pre-Fertilization Parameters
Oocyte selection in contemporary clinical IVF: do follicular markers of oocyte competence exist?
301(24)
Jonathan Van Blerkom
Susan W Trout
Sperm DNA and embryo development
325(12)
Denny Sakkas
Emre Seli
The sperm centriole: its effect on the developing embryo
337(18)
Calvin R Simerly
Christopher S Navara
Index 355


Jacques Cohen, Kay Elder