Imaging Neuroinflammation provides an overview of the molecular and cellular basis of inflammation and its effects on neuroanatomy, reviews state-of-the-art imaging tools available to measure neuroinflammation, and describes the application of those tools to both preclinical animal disease models and human disease.This book is an authoritative reference on imaging neuroinflammation, MRI, neuroinflammation, MR Spectroscopy of inflammation, Iron imaging in inflammation, and more.
- Explains how inflammation in the central nervous system impacts tissue microstructure
- Presents imaging methods that are useful for assessing neuroinflammation
- Describes preclinical models of neuroinflammation
- Reviews the role of neuroinflammation in human injury and disease states
1. Molecular and tissue basis of inflammation in health and disease
(Marion Tible, Thomas Tourdias)
Imaging Approaches to Inflammation
2. Sensitivity and specificity of diffusion MRI to neuroinflammatory
processes (Ileana O. Jelescu, Els Fieremans)
3. Iron imaging in neuroinflammation (Vanessa Wiggermann)
4. MRS in neuroinflammation (Ashley D. Harris, Erin L. MacMillan)
5. Magnetization transfer and chemical exchange saturation transfer in
neuroinflammation (Seth A. Smith, Kristin P. OGrady, Anna J.E. Combes, Colin
McKnight, Francesca R. Bagnato)
6. Gadolinium based imaging of the blood brain barrier and of the brain
waste clearance pathways (Nivedita Agarwal, Daniel M. Harrison)
7. Magnetic particle imaging (Natasha N. Knier, Olivia C. Sehl, Julia J.
Gevaert, Ashley V. Makela, Paula J. Foster)
8. Positron Emission Tomography Tracers for Detecting Inflammation (Shalini
Sharma, Mukesh K. Pandey)
Animal Models
9. The use of animal models of neuroinflammation for imaging studies (Jeff
Dunn, Qandeel Shafqat)
Human inflammation-based diseases
10. Stroke (Jennifer K. Ferris, Lucero Aceves-Serrano, Justin W. Andrushko,
Lara A. Boyd)
11. Central Nervous System Vasculitis (Wenjie Yang, Bruce A. Wasserman)
12. Dementia (Maura Malpetti, James B Rowe, Li Su, John T OBrien)
13. Parkinsons Disease (Shu-Ying Liu, Vesna Sossi)
14. Amyotrophic lateral sclerosis (Sicong Tu, Matthew Kiernan)
15. Multiple sclerosis (Nara Miriam Michaelson, Neha Vijayvargiya Safi,
Ulrike W. Kaunzner, Susan A. Gauthier)
16. Pediatric Leukodystrophies (Deborah L. Renaud)
17. Lupus (Theodor Rumetshofer, Efrosini Papadaki, Andreas Jönsen, Pia C.
Sundgren)
18. Autoimmune Encephalitis (Vyanka Redenbaugh, Eoin P. Flanagan)
19. Neuroinflammation and schizophrenia spectrum disorders (S. Andrea
Wijtenburg, Laura M. Rowland)
Dr. Cornelia (Corree) Laule is a physicist who has been involved with nuclear magnetic resonance and magnetic resonance imaging research for more than 25 years. She completed a postdoctoral fellowship in neuropathology focusing on MRI pathology correlation studies in multiple sclerosis brain tissue. She has been a faculty member at the University of British Columbia since 2013. Dr. Laules main interests are the development, validation, and application of quantitative magnetic resonance methods for brain and spinal cord imaging with emphasis on myelin, axons, and inflammation.
Dr. John D. Port received his BS in electrical engineering and computer science from MIT in 1986, then attended the University of Illinois at Chicago for his MD and PhD training. He completed his radiology residency and fellowship at Johns Hopkins Hospital in 2000 and has been working at Mayo Clinic since. Dr. Ports main interests are the applications of novel magnetic resonance spectroscopy and imaging techniques to numerous psychiatric and neurological diseases, including demyelinating disorders.
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