| Preface |
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vii | |
| Acknowledgments |
|
ix | |
| To the Reader |
|
xi | |
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Introduction to Immunity and the Nonspecific Immune System |
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1 | (18) |
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1 | (2) |
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Mechanical, chemical, and physiologic factors |
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3 | (1) |
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4 | (6) |
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10 | (2) |
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12 | (7) |
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Immunogens and Immunizations |
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19 | (14) |
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19 | (2) |
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21 | (1) |
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22 | (1) |
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22 | (1) |
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23 | (2) |
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25 | (2) |
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Experimental immunization procedures |
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27 | (6) |
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33 | (20) |
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33 | (1) |
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General immunoglobulin structure |
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33 | (5) |
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Structure and function of specific immunoglobulins |
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38 | (3) |
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41 | (6) |
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47 | (6) |
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53 | (18) |
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53 | (2) |
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Pathways of complement activation |
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55 | (5) |
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The membrane attack pathway (the common pathway) |
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60 | (1) |
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Biologic consequences of complement activation |
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61 | (3) |
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64 | (7) |
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The Immune Response System and Its Regulation |
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71 | (28) |
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71 | (1) |
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72 | (1) |
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73 | (3) |
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General characteristics of T cells |
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76 | (7) |
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General characteristics of B cells |
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83 | (1) |
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Exposure to an antigenic substance |
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84 | (3) |
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Phases of the humoral immune response |
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87 | (1) |
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Regulation of the immune response |
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88 | (1) |
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89 | (2) |
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91 | (1) |
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92 | (7) |
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99 | (10) |
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In vitro antigen-antibody reactions |
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99 | (1) |
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Procedures involving direct demonstration and observation of reactions |
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99 | (3) |
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Complex serologic procedures |
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102 | (2) |
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Assays of immune competence |
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104 | (1) |
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Identification of immediate (type I) hypersensitivity reactions due to lgE |
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105 | (1) |
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Production and use of monoclonal antibodies |
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106 | (3) |
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Immunologic Mechanisms of Tissue Damage |
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109 | (20) |
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109 | (1) |
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Immediate hypersensitivity (type I) reactions |
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109 | (5) |
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Cytotoxic (type II) reactions |
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114 | (2) |
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Immune complex-mediated (type III) reactions |
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116 | (3) |
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Cell-mediated reactions (type IV): delayed hypersensitivity and cell-mediated cytotoxicity |
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119 | (10) |
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129 | (20) |
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129 | (5) |
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Representative autoimmune diseases |
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134 | (15) |
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Immunodeficiency Disorders |
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149 | (18) |
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150 | (1) |
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151 | (2) |
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B-cell deficiency disorders |
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153 | (2) |
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T-cell deficiency disorders |
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155 | (1) |
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Combined B-cell and T-cell deficiency disorders |
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156 | (2) |
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Secondary immunodeficiency conditions |
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158 | (1) |
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159 | (8) |
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Transplantation and Tumor Immunology |
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167 | (28) |
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167 | (13) |
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180 | (15) |
| Case Studies |
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195 | (20) |
| Comprehensive Examination |
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215 | (38) |
| Appendix---Normal Values |
|
253 | (2) |
| Index |
|
255 | |
