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mmunopathology, Diagnosis and Treatment of HPV induced Malignancies focuses on the human papilloma virus infection and associated cancers. In ten chapters, the book explains the deep knowledge about molecular mechanism in HPV pathogenesis and recent advanced tools applied in the field of HPV induced cancer and cures. In a nutshell, the book gives new insights and the associated challenges involved in the identification of promising drug and vaccine targets, current diagnostic tools, and advancements in current therapies against HPV induced cancers and other malignancies.
- Highlights the concept of Human papilloma virus infection, its pathogenesis, mechanisms involved in host immune response, clinical manifestations, prophylactic and therapeutic strategies, and recent advancements for the cure of HPV induced cancer
- Delineates new insights and challenges involved in the identification of promising drug and vaccine targets, current diagnostic tools, and advancements in current therapies against HPV induced cancer
- Provides comprehensive and conceptual knowledge that could be a milestone not only in the field of infectious cancers but also for researchers and scientists working on infectious cancer
1. An overview of HPV: cause, symptoms and clinical manifestation
2. Pathogenesis and immune response against HPV infection
3. Malignancies associated with HPV infection
4. Immunological aspects of HPV/HIV co-infection and risk of gynaecological diseases
5. Cervico-vaginal microbiota and HPV induced cervical cancer
6. Current diagnostic tools for HPV
7. Animal models for the discovery of therapeutic and prophylactic measures against HPV induced malignancies
8. Potential drug targets against HPV and repurposing of existing drugs
9. Recent advances and strategies in vaccine development against HPV
10. Available immunotherapies and future opportunities to prevent HPV-associated cancers
Dr. Prashant Khare is a Vice President (R&D) at Xenesis Institute, Absolute in Gurugram (Haryana), India. Previously, he was a Ramalingaswami Fellow and Scientist D in the Department of Microbiology at the All India Institute of Medical Sciences, Bhopal, India. He completed his PhD from the Division of Parasitology at the Central Drug Research Institute in Lucknow, (Uttar Pradesh), India. He has almost five years of postdoctoral experience from the Baylor Institute for Immunology Research and UT Southwestern Medical Center in Dallas, Texas, USA, and more than 15 years of research experience in the field of infectious biology, immunology, vaccine, and drug development. He has published more than 30 research papers in highly reputable international journals such as Nature Immunology and Nature Communication. He has reviewed publications and served in an editorial role for several international journals as well. Dr. Ashish Jain is working as an Assistant Professor (senior scale) since last eleven years in the Department of Microbiology, Smt. CHM College Ulhasnagar; affiliated with the University of Mumbai (Maharashtra), India. He has completed his PhD from Division of Endocrinology, Central Drug Research Institute, Lucknow (Uttar Pradesh) India on spermicides and anti-Trichomonas molecules and their mode of action. He has published more than 20 reputed international research papers and reference books in the field of Sexually transmitted infections and reproductive biology and credited international patents in his account. He is a recognized postgraduate teacher and PhD guide of University of Mumbai in Microbiology subject. Presently he is working to investigate the role of vaginal microbiota on reproductive health.
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