This book brings together experts from leading global institutions with diverse backgrounds and experiences for clinical perspectives on Infectious Endocarditis (IE) in all stages. In the past, this disease claimed lives within as little as 2-3 months; advanced diagnostics, pharmacological treatments, and team-based care have significantly improved patient outcomes, yet there are very few resources available for physicians who need to work together to make this possible. This book bridges this gap, exploring medical and surgical treatments in a wider portion of the medical community. The clinical presentation and management of patients with IE is the starting point for significant change in how physicians approach this problem.
Infectious Endocarditis is an excellent multidisciplinary resource for infectious disease specialists, primary care physicians, neurologists, cardiologists, radiology, emergency medicine, addiction medicine specialists, surgeons, and all others who may encounter this condition.
Part I: Epidemiology and Team-Based Care.- Introduction.- Natural
history and evolution of the Treatment of Endocarditis.- Epidemiology of
endocarditis, past and present.- Pathogens and virulence and virulence
factor.- Pathology.- Multidisciplinary Team Approach to Management of
Endocarditis: A Team of Teams.- Part II: Clinical Presentation and
Diagnosis.- Common and Uncommon Pathogens causing Infectious Endocarditis.-
Basic Science aspects on the Pathophysiology of Infectious
Endocarditis.- Pathology and Histopathology of Infective
Endocarditis.- Infective Endocarditis: Which are the differences related to
affected valve and organism.- Clinical Presentation of Infecive
Endocarditis.- Microbiological Testing.- Cardiac Imaging in the diagnosis of
Infective endocarditis.- Neurologic Complications, presentation and
diagnosis.- Role of neuro-interventions and surgery for infectious brain
complications.- Renal manifestations in the setting of infective
endocarditis.- Part III: Management for Infectious Endocarditis.- Guidelines
for Infective Endocarditis.- Combined Antimicrobial Therapy for Infective
Endocarditis.- Indications and timing of surgery (including indications for
extra cardiac infectious foci).- Medical Management of Prosthetic Valve
Endocarditis.- Pre-operative Evaluation and Work-up and of the patient with
Infective Endocarditis requiring Surgery.- Non-surgical treatment of large
tricuspid valve vegetations.- Part IV: Surgery for Infectious
Endocarditis.- Pre-operative check list in endocarditis
patients.- Intraoperative Transesophageal Echocardiography in the Cardiac
Surgical Patient with Infective Endocarditis.- Perioperative Hemodynamic and
Hemostasis Management.- Cardiopulmonary Bypass Approach for
Endocarditis.- General Principles for Surgical Treatment of Infective
Endocarditis.- Aortic root replacement with cryopreserved allograft for
endocarditis.- Alternatives to Allografts for Aortic Endocarditis:
Bioprosthetic and Mechanical Valves.- Surgery for Mitral Valve Endocarditis
with Focus on Repair and Reconstruction.- Reconstruction of the Left
Ventricular Outflow Tract in patients with destruction of the Intervalvular
Fibrosa, the Commando Operation.- The Hemi-Commando Procedure for
Endocarditis of the Aortic Root & Aortomitral Fibrosa.- Surgery for
right-sided endocarditis - How to avoid replacing the tricuspid valve.- Role
of pulmonary vegetectomy in right sided endocarditis. Lessons learned from a
tertiary center experience.- Lead Management for Cardiovascular Implantable
Electronic Devices in Pa-tients Requiring Cardiac Surgery for Infective
Endocarditis.- Postoperative intensive care after surgery for infectious
endocarditis.- Part V: Follow up and Prevention of infectious
endocarditis.- Prognosis and Follow up in Infective Endocarditis.- Infectious
Endocarditis: Prevention and antibiotic prophylaxis.- Should the risk of
infectious endocarditis impact the choice of prosthesis for non-infectious
valve pathologies?.- Part VI: Special Populations.- 'Treating Substance Use
Disorder Problems in the Endocarditis Patient.- Surgery for infectious
endocarditis in patients on dialysis.- Lead Management for Cardiovascular
Implantable Electronic Devices in Patients Requiring Cardiac Surgery for
Infective Endocarditis.- Thoracic Aorta and Graft Infections.- Management of
peripheral mycotic aneurysms and Use of deep femoral vein in patients with
aortic infections.- Management of Splenic Abscess in Patients with Infective
Endocarditis.- Endocarditis in Children and Patients with Congenital Heart
Disease.- Infectious Endocarditis after TAVR.- Ventricular assist device
infections.- Mycobacterium chimaera: Infections after Open Heart
Surgery.- Part VII: Past and Future directions.- The Evolution of Surgical
Treatment of Infective Endocarditis. My personal perspective!.
Gosta Pettersson, MD
Vice Chairman and Section Head Department of Cardiovascular Surgery
Heart and Vascular Institute
Cleveland Clinic
Paul Cremer, MD
Staff Cardiovascular Medicine
Heart and Vascular Institute
Cleveland Clinic
Steven Gordon, MD
Chairman Infectious Disease
Medicine Institute
Cleveland Clinic
Brian Griffin, MD
Staff and Section Head Cardiovascular Medicine
Heart and Vascular Institute
Cleveland Clinic
Nabin Shrestha, MD
Infectious Disease
Medicine Institute
Cleveland Clinic
Shinya Unai, MD
Cardiovascular Surgery
Cleveland Clinic
