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Inflammation and Natural Products [Mīkstie vāki]

Edited by (Indian Institute of T), Edited by (Senior Scientist, Department of Research and Development, Molecules Food Solutions Private Limited, Kerala, India), Edited by , Edited by (Co-Founder and Director of Molecules Food Solutions Pvt Ltd, Zingon Naturals Pvt Ltd., India)
  • Formāts: Paperback / softback, 462 pages, height x width: 235x191 mm, weight: 930 g
  • Izdošanas datums: 21-Jan-2021
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0128192186
  • ISBN-13: 9780128192184
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  • Mīkstie vāki
  • Cena: 178,26 €
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  • Formāts: Paperback / softback, 462 pages, height x width: 235x191 mm, weight: 930 g
  • Izdošanas datums: 21-Jan-2021
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0128192186
  • ISBN-13: 9780128192184
Citas grāmatas par šo tēmu:

Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.

  • Increases the knowledge of anti-inflammatory activities of natural products and their mechanism of action
  • Provides a new perspective and forward-thinking ideas to researchers, the scientific community and industry
  • Intensifies the understanding of synergistic action of biologically active naturally occurring molecules and their biological activities against inflammation
Contributors xiii
Chapter 1 Inflammation, symptoms, benefits, reaction, and biochemistry
1(20)
Akhila Nair
Roshin U. Thankachen
Jithin Raj
Sreeraj Gopi
1.1 Introduction
1(1)
1.2 Causes and symptoms of inflammation
1(1)
1.3 Types of inflammation
2(2)
1.4 Benefits of inflammation
4(6)
1.5 Reactions and biochemistry
10(6)
1.6 Conclusion
16(1)
References
17(4)
Chapter 2 Molecular pharmacology of inflammation: Medicinal plants as antiinflammatory agents
21(44)
Muhammad Daniyal
Wei Wang
2.1 Introduction
21(1)
2.2 Antiinflammatory agent molecular targets
22(1)
2.3 Inflammatory mediators, receptors, and major signaling pathways
23(10)
2.4 Cell signaling pathways involved in inflammation
33(2)
2.5 Antiinflammatory potential of medicinal plants and their active constituents
35(7)
2.6 Inflammatory pathways as potential targets for natural bioactive compounds
42(2)
2.7 Antiinflammatory activity of natural bioactive compounds
44(7)
2.8 Conclusion
51(1)
Acknowledgments
52(1)
Conflict of interest
53(1)
References
53(12)
Chapter 3 Natural products with antiinflammatory activities against autoimmune myocarditis
65(18)
Akhila Nairand Sreeraj Gopi
3.1 Introduction
65(1)
3.2 Myocarditis
66(1)
3.3 Etiology and pathogenesis of autoimmune myocarditis
67(2)
3.4 Antiinflammatory mechanism for autoimmune myocarditis
69(3)
3.5 Natural products renowned for antiinflammatory activity
72(7)
3.6 Conclusion
79(1)
References
80(3)
Chapter 4 Multitarget approach for natural products in inflammation
83(30)
Shintu Jude
Sreeraj Gopi
4.1 Introduction
83(1)
4.2 Mechanisms: Mediators and pathways behind inflammation
84(9)
4.3 Distinct pathways behind neuroinflammation; Alzheimer's disease as a case
93(2)
4.4 Multitarget approach for antiinflammatory action
95(1)
4.5 Natural compounds with multitarget in antiinflammation
96(7)
4.6 Combination of phytochemicals
103(1)
4.7 Conclusion
104(1)
References
105(8)
Chapter 5 Antiinflammatory activity of natural dietary flavonoids
113(14)
Matheus Chiaradia de Souza
Ana Laura Tironi de Castilho
Carolina Mendes Tarran
Mateus Souza Zabeu
Leonardo de Liori Teixeira
Ariane Leite Rozza
5.1 Introduction
113(2)
5.2 Flavonoids and cardiovascular diseases
115(1)
5.3 Flavonoids and diabetes mellitus
116(4)
5.4 Flavonoids and gastrointestinal diseases
120(2)
5.5 Conclusion and perspectives
122(1)
References
122(5)
Chapter 6 Antiinflammatory effects of turmeric (Curcuma longa) and ginger (Zingiber officinale)
127(20)
Thahira Banu Azeez
Janeline Lunghar
6.1 Introduction
127(1)
6.2 Turmeric
128(8)
6.3 Ginger (Zingiber officinale)
136(6)
6.4 Conclusion
142(1)
References
142(5)
Chapter 7 Antiinflammatory activity of Boswellia
147(14)
Karthik Varma
Jozef T. Haponiuk
Sreeraj Gopi
7.1 Introduction
147(1)
7.2 Taxonomy and phytochemistry
148(1)
7.3 Pharmacological activities of Boswellia
148(2)
7.4 Preclinical studies
150(2)
7.5 Clinical studies of the antiinflammatory action
152(2)
7.6 Toxicity and side effects in clinical evaluations
154(1)
7.7 Conclusion
155(1)
References
155(6)
Chapter 8 Antiinflammatory activity of galangal
161(14)
Karthik Varma
Jozef T. Haponiuk
Sreeraj Gopi
8.1 Introduction
161(1)
8.2 Phytochemistry
162(2)
8.3 Mechanism of antiinflammatory pathway
164(1)
8.4 Pharmacological activities
165(3)
8.5 Usage in traditional systems
168(1)
8.6 Toxicity studies
169(1)
8.7 Conclusion
169(1)
References
170(5)
Chapter 9 Antiinflammatory natural products from marine algae
175(30)
Ayman M. Mahmoud
May Bin-Jumah
Mohammad H. Abukhalil
9.1 Introduction
175(2)
9.2 Inflammation
177(2)
9.3 Algal natural products with antiinflammatory activity
179(13)
9.4 Conclusions
192(1)
Conflict of interest
192(1)
References
192(13)
Chapter 10 Medicinal plants and their potential use in the treatment of rheumatic diseases
205(30)
Diego P. de Oliveira
Fernao C. Braga
Mauro M. Teixeira
10.1 Introduction
205(1)
10.2 Herbal products currently used in antiarthritic therapy
206(19)
10.3 Conclusion and perspectives
225(1)
References
226(9)
Chapter 11 Natural product-derived drugs for the treatment of inflammatory bowel diseases (IBD)
235(26)
Cristina C. Salibay
Tooba Mahboob
Ajoy Kumar Verma
Jonnacar S. San Sebastian
Hazel Anne Tabo
Chandramathi Samudi Raju
Veeranoot Nissapatorn
11.1 Introduction
235(1)
11.2 Epidemiology
236(1)
11.3 Pathogenesis
236(4)
11.4 The role of natural products on IBD
240(2)
11.5 Natural products for ulcerative colitis and Crohn's disease
242(11)
11.6 Conclusion remarks and future perspective
253(1)
References
254(7)
Chapter 12 Smart drug delivery systems of natural products for inflammation: From fundamentals to the clinic
261(22)
Akhila Nair
Bincicil Annie Varghese
Sreeraj Gopi
Joby Jacob
12.1 Introduction
261(1)
12.2 Stimuli-responsive drug delivery system
262(17)
12.3 Conclusion
279(1)
References
280(3)
Chapter 13 Systems pharmacology and molecular docking strategies prioritize natural molecules as antiinflammatory agents
283(38)
Anjana S. Nair
Anupam Paliwal
13.1 Introduction
283(6)
13.2 Systems pharmacology and anti-inflammatory agents
289(2)
13.3 Computational methodologies and molecular docking studies with natural compounds
291(1)
13.4 Inflammatory pathway network and key node targets of antiinflammatory agents
292(3)
13.5 Prioritization strategy and systems pharmacology approach for screening of potential therapeutic agents
295(2)
13.6 Natural compounds and their interactions in the inflammatory pathway network and prioritization as antiinflammatory agents
297(14)
13.7 Conclusion
311(1)
References
312(9)
Chapter 14 Bioavailability, pharmacokinetic, pharmacodynamic, and clinical studies of natural products on their antiinflammatory activities
321(38)
Akhila Nair
Sreeraj Gopi
Joby Jacob
14.1 Introduction
321(1)
14.2 Antiinflammatory activities of natural products
322(31)
14.3 Conclusion
353(1)
References
354(5)
Chapter 15 Supplements and diets for antiinflammation
359(18)
A. Thahira Banu
Janeline Lunghar
15.1 Introduction
359(1)
15.2 Types of inflammatory
359(2)
15.3 Antiinflammatory supplements
361(6)
15.4 Role of diet in body inflammation
367(2)
15.5 Nutrient effects on chronic inflammation
369(1)
15.6 Conclusion
370(1)
References
371(6)
Chapter 16 Values of natural products to future anti-inflammatory pharmaceutical discovery
377(30)
Augustine Amalraj
Sreeraj Gopi
16.1 Introduction
377(2)
16.2 Inflammatory mediators
379(1)
16.3 Antiinflammatory therapy and response
379(1)
16.4 Nonsteroidal antiinflammatory drugs vs inflammation
380(1)
16.5 Biodiversity of plant natural products
381(1)
16.6 Medicinal plants as gift of nature
381(2)
16.7 Herbal remedies in traditional medication for inflammation
383(1)
16.8 Ayurvedic formulation for inflammation
384(1)
16.9 Natural products--A promising antiinflammatory pharmaceutical drug discovery
385(9)
16.10 Major challenges in upgrading natural products
394(1)
16.11 Future prospective and conclusions
395(1)
References
395(12)
Chapter 17 Identification of toxicology biomarker and evaluation of toxicity of natural products by metabolomic applications
407(30)
N.S.K. Gowthaman
H.N. Lim
Sreeraj Gopi
Augustine Amalraj
17.1 Background
407(3)
17.2 Metabolomic technology
410(1)
17.3 Sample preparation
411(1)
17.4 Data analysis
412(3)
17.5 Metabolomics in toxicity evaluation and biomarker identification of natural products
415(15)
17.6 Concluding remarks and perspectives
430(1)
References
431(6)
Index 437
Dr. Sreeraj Gopi is the Co-Founder and Director of Molecules Food solutions Pvt Ltd, Zingon Naturals Pvt Ltd. He was the Chief Scientist at Plant Lipids Pvt Ltd. and Chief Scientific Officer at Aurea Biolabs Pvt Ltd., He has also served as an adjunct professor at universities including Stockholm University, Sweden, Siberian Federal University, Russia, and Mahatma Gandhi University, India. He completed his doctorate in organic chemistry and nanotechnology, and nano drug delivery working in the area of natural products, isolation, and biological activities. He published more than 175 international articles and filed more than 75 patents, in the US and Europe. At Plant Lipids, he developed many innovative products and technologies, and is responsible for driving the research team to excellence, as well as, implementing new projects, presenting scientific seminars to various customers. He was listed world's top 2% scientist list by Standford University.

Dr. Augustine Amalraj is currently working as a Senior Scientist in the Department of Research and Development at Molecules Food Solutions Private Limited, Koratty, Thrissur, Kerala, India. He was worked as a Deputy Manager in the Department of Research and Development at Plant Lipids Private Limited and Aurea Biolabs Private Limited, Cochin, India. He obtained his Doctoral degree in Chemistry from Gandhigram Rural Institute Deemed University, Gandhigram, Tamil Nadu, India. His research interests are in applied chemistry, food chemistry, natural product chemistry, environmental chemistry, chemosensors, and polymer and nanocomposite materials. He has published more than 60 research articles in international journals, as well as 22 book chapters, co-edited 10 books and filed 3 patents. He was listed among the top 2% of scientists in the world by Stanford University. Prof. Ajaikumar Kunnumakkara, is a faculty member in the Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India. He is also an Honorary Chair Professor in Nanoscience and Nanotechnology. He is the principal investigator of Unit of Excellence in cancer drug discovery (DBT, Govt. of India) and the coordinator of DBT (India) - AIST (Japan) International Laboratory for Advanced Biomedicine. He earned his doctorate in 2006 from Amala Cancer Research Center, Thrissur, affiliated with University of Calicut, Kerala, India. Dr. Kunnumakkara did postdoctoral work at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA (20052008) and the National Cancer Institute of National Institutes of Health (20082010) where he was subsequently employed as an NIH Scientist until 2012. Dr. Kunnumakkara has also edited four monographs. He is an elected Fellow of Royal Society of Medicine, UK as well as belonging to many other esteemed institutions. Dr. Sabu Thomas (Ph.D.) is the Director of the School of Energy Materials, School of Nanoscience and Nanotechnology of Mahatma Gandhi University, India. He received his Ph. D. in 1987 in Polymer Engineering from the Indian Institute of Technology (IIT), Kharagpur, India. He is a fellow of the Royal Society of Chemistry, London, and a member of the American Chemical Society. He has been ranked no.1 in India about the number of publications (most productive scientists). Prof. Thomass research group specialized areas of polymers which includes Polymer blends, Fiber filled polymer composites, Particulate-filled polymer composites and their morphological characterization, Ageing and degradation, Pervaporation phenomena, sorption and diffusion, Interpenetrating polymer systems, Recyclability and reuse of waste plastics and rubbers, Elastomer cross-linking, Dual porous nanocomposite scaffolds for tissue engineering, etc. Prof. Thomass research group has extensive exchange programs with different industries, research, and academic institutions all over the world and is performing world-class collaborative research in various fields. Professors Centre is equipped with various sophisticated instruments and has established state-of-the-art experimental facilities which cater to the needs of researchers within the country and abroad. His H Index- 133, Google Citations- 86424, Number of Publications- 1300, and Books-160.