E-grāmata: Information Technology Framework for Predictive, Preventive and Personalised Medicine: A Use-Case with Hepatocellular Carcinoma

This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determine how a clinical liver cancer center can contribute; and, (4) examine the enhancements and impact that the first three tasks will have on the management of HCC. An IT System for Personalized Medicine (ITS-PM) for HCC will provide the means to identify and determine the relative value of the wide number of variables, including clinical assessment of the patient -- functional status, liver function, degree of cirrhosis, and comorbidities; tumor biology, at a molecular, genetic and anatomic level; tumor burden and individual patient response; medical and operative treatments and their outcomes

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PrefaceChapter 1 IntroductionLeonard Berliner and Heinz U. LemkeChapter 2 The Digital Patient Model and Model Guided TherapyLeonard Berliner and Heinz U. LemkeChapter 3 Hepatocellular Carcinoma and Patient AssessmentSmruti Mohanty, Sid Verma, David Dosik, Hesham Hazin and Leonard BerlinerChapter 4 Imaging in Hepatocellular Carcinoma: Radiologic AssessmentIrene Bargellini, Valentina Battaglia, Davide Caramella and Carlo BartolozziChapter 5 Imaging in Hepatocellular Carcinoma: PET/CTGiuseppe EspositoChapter 6 Personalized Chemotherapy for Hepatocellular CarcinomaHesham Hazin and David DosikChapter 7 Surgical Treatment for Hepatocellular Carcinoma Smruti Mohanty, Leonard Berliner and Syed ShahChapter 8 Minimally Invasive Therapies for Hepatocellular Cancer: Ablation TechnologiesPaul Morrison and Eric vanSonnenbergChapter 9 Minimally Invasive Therapies for Hepatocellular Cancer: Ablation TherapiesEric vanSonnenberg and Leonard BerlinerChapter 10 Minimally I

nvasive Therapies for Hepatocellular Cancer: Catheter-Directed TherapiesLeonard Berliner and Smruti MohantyChapter 11 Radiation Oncology in the Treatment of Hepatocellular CarcinomaHani Ashamalla and Malcom D. MattesChapter 12 Design of an IT System for Hepatocellular CarcinomaLeonard Berliner and Heinz U. LemkeChapter 13 Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocellular CarcinomaLeonard Berliner, Heinz U. Lemke, Hani Ashamalla and Smruti Moha