This text is derived from an international symposium held in Nagoya, Japan, in December 2005, on pathogenesis and therapy development for neurological and psychiatric disorders. Twenty contributions are organized into sections on motor neuron diseases, Alzheimer's disease and related neurodegenerative disorders, neuroprotective strategy for neurodegenerative diseases, neuronal polarity and psychiatric disorders, and novel targets for cancer therapy. A sampling of topics: gene expression profiling toward understanding of ALS pathogenesis, brain keratan sulfate and glial scar formation, molecular mechanisms of axon specification and neuronal disorders, and involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells. No subject index. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)
Neurodegenerative disorders and malignant tumors are usually resistant to any treatment, and the mortality rate is very high for persons with these conditions. Accordingly, finding effective treatments for these diseases is one of the most serious issues for medicine in the 21st century.
In this volume, the molecular mechanisms of neurodegenerative disorders and malignant tumors are addressed, as are new therapeutic tools that exploit our understanding of these disease mechanisms. Substantial evidence for the existence of common molecular pathways for both neurodegeneration and tumor growth has been found, and many novel molecules related to both of them have also been discovered.
Because integrated research on neuronal and neoplastic disorders is singularly effective in overcoming these disorders, this volume will be an excellent source of information on the state of the research in this field and on the development of its applications in human disease therapy.
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