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Introduction to Nanomedicine and Nanobioengineering [Hardback]

(State University of New York, Buffalo)
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Introduction to Nanomedicine and NanobioengineeringPalielināt
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Permanent link: https://www.kriso.lv/db/9781118093436.html
Keywords:
This book is an introduction to the emerging field of nanomedicine and its applications to health care. It describes the many multidisciplinary challenges facing nanomedicine and discusses the required collaboration between chemists, physicists, engineers and clinicians. The book introduces the reader to nanomedicine's vast potential to improve and extend human life through the application of nanomaterials in diagnosis and treatment of disease.

Recenzijas

This volume is most handy for those in the physics, chemistry, or materials science fields who are interested in biomedical applications of nanotechnology; it would also be useful for those in the biological or medical fields who are interested in learning how nanotechnology would be beneficial to their research.  Summing Up: Recommended.  Upper-division undergraduates and above.  (Choice, 1 January 2013)

Preface xiii
Acknowledgments xv
1 Introduction
1(14)
1.1 Nanomedicine: A Global Vision
1(2)
1.2 The Nanotechnology Revolution: Realization of Asimov's Fiction
3(4)
1.3 Nanomedicine: A New Era in Personalized Medicine
7(2)
1.4 Nanomedicine: A Promise or Reality?
9(1)
1.5 A New Frontier: Multidisciplinary Challenges and Opportunities
10(2)
1.6 Scope of the Book: Multidisciplinary Education, Training, and Research
12(1)
References
13(2)
2 The Human Body
15(36)
2.1 Introductory Concepts
16(2)
2.2 Cellular Structure
18(5)
2.3 Various Types of Cells
23(2)
2.4 Biochemical Makeup of Cells
25(4)
2.5 Other Important Cellular Components
29(1)
2.6 Cellular Processes
30(7)
2.7 Organization of Cells into Tissues
37(2)
2.8 Types of Tissues and Their Functions
39(1)
2.9 Various Organs and Organ Systems in the Body
40(5)
2.10 Tumors and Cancers
45(1)
Highlights of the
Chapter
46(2)
Exercises
48(1)
References
49(2)
3 Nanocarriers
51(26)
3.1 Nanocarriers: Delivering Payloads to Needed Sites
52(1)
3.2 The Various Nanoformulations for Nanomedicine
53(2)
3.3 Viruses as Nanocarriers
55(1)
3.4 Polymeric Nanocarriers
56(2)
3.5 Lipid-Based Nanocarriers
58(1)
3.6 Dendrimers
59(2)
3.7 Carbon Nanostructures
61(2)
3.8 Inorganic Nanoparticles
63(2)
3.9 Pebble
65(1)
3.10 Nanoclinics
66(2)
3.11 Nanoplexes
68(1)
3.12 New-Generation Nanocarriers
69(1)
Highlights of the
Chapter
70(2)
Exercises
72(1)
References
73(4)
4 Nanochemistry Of Nanocarriers
77(26)
4.1 Nanochemistry and Nanomedicine
78(1)
4.2 Top-Down Approaches
78(5)
4.2.1 Mechanical Milling
79(1)
4.2.2 Dip-Pen Nanolithography
79(2)
4.2.3 Print Process
81(1)
4.2.4 Laser Ablation
81(2)
4.3 Bottom-Up Approaches
83(9)
4.3.1 Dendrimers
83(3)
4.3.2 Microemulsion Chemistry
86(1)
4.3.3 Hot-Colloidal Synthesis
87(3)
4.3.4 Seed-Mediated Synthesis of Anisotropic Metallic Nanostructures
90(1)
4.3.5 Reprecipitation Method
90(2)
4.4 Combination of Bottom-Up and Top-Down Approaches
92(1)
4.5 Nanoparticle Surface Modification
93(2)
4.6 Functionalization and Bioconjugation
95(2)
Highlights of the
Chapter
97(2)
Exercises
99(1)
References
100(3)
5 Multifunctionalities For Diagnostics And Therapy
103(32)
5.1 The Various Functionalities
104(1)
5.2 Optical Functionalities
105(5)
5.3 Optical Nanoprobes
110(6)
5.4 Magnetic Functionality
116(4)
5.5 Thermal Functionality
120(1)
5.6 Radioactive Functionality
121(3)
5.7 Biological Functionality
124(1)
5.8 Multifunctionality
125(3)
Highlights of the
Chapter
128(2)
Exercises
130(1)
References
131(4)
6 Crossing The Biological Barriers
135(14)
6.1 Various Delivery Pathways
135(2)
6.2 Various Biological Barriers
137(3)
6.3 Stealth Nanoparticles
140(1)
6.4 The Various In Vitro Barrier Models
141(3)
Highlights of the
Chapter
144(1)
Exercises
145(1)
References
146(3)
7 Biotargeting
149(14)
7.1 Biotargeting: Why We Need It
149(1)
7.2 Targeted Biological Sites
150(1)
7.3 Intracellular Uptake
151(2)
7.4 Targeting Strategies
153(2)
7.5 Targeting Groups
155(4)
Highlights of the
Chapter
159(1)
Exercises
160(1)
References
161(2)
8 Multimodal Biomedical Imaging
163(44)
8.1 Biomedical Imaging Techniques
164(6)
8.2 Optical Bioimaging
170(15)
8.2.1 Fluorescence Microscopy
170(2)
8.2.2 Quantitative FRET Microscopy
172(3)
8.2.3 Technical Challenges for In Vitro Imaging
175(2)
8.2.4 In Vivo Optical Imaging
177(1)
8.2.5 Optical Coherence Tomography
177(4)
8.2.6 Super-Resolution Fluorescence Microscopy
181(4)
8.3 Magnetic Resonance Imaging
185(3)
8.4 X-Ray CT Imaging
188(2)
8.5 Radio Imaging
190(1)
8.6 Ultrasound Imaging
190(1)
8.7 Photoacoustic Imaging
191(1)
8.8 Multimodal Imaging
192(1)
Highlights of the
Chapter
193(7)
Exercises
200(1)
References
201(6)
9 Biosensing
207(46)
9.1 Principles of Biosensing
208(3)
9.2 Optical Biosensors
211(17)
9.2.1 Fluorescencs Sensors
211(7)
9.2.2 Plasmonic Sensors
218(9)
9.2.3 Photonic Crystal Sensors
227(1)
9.3 Magnetic Biosensors
228(6)
9.4 Electrical Biosensing
234(2)
9.5 Electrochemical Biosensing
236(2)
9.6 Electrochemiluminescence Biosensing
238(1)
9.7 In Vivo Bioelectronic Sensors
239(2)
Highlights of the
Chapter
241(4)
Exercises
245(2)
References
247(6)
10 High-Throughput Multiplexed Diagnostics
253(38)
10.1 Comprehensive Diagnostic Strategy
254(1)
10.2 Flow Cytometry
255(9)
10.3 Enzyme-Linked Immunosorbent Assay (ELISA)
264(5)
10.4 Microarrays Technology
269(8)
10.5 Suspension Bead Assay
277(4)
Highlights of the
Chapter
281(4)
Exercises
285(1)
References
286(5)
11 Nanopharmacotherapy
291(14)
11.1 Nanopharmacotherapy: An Overview
292(2)
11.2 Modes of Nanoformulation for Nanopharmacotherapy
294(2)
11.3 Pharmacokinetics
296(1)
11.4 Biodistribution
297(1)
11.5 Pharmacodynamics
298(1)
11.6 Controlled Release by External Activation
299(1)
Highlights of the
Chapter
300(2)
Exercises
302(1)
References
303(2)
12 The Human Circulatory System And Theranostics
305(26)
12.1 Blood Fluidics and Cardiovascular System
306(3)
12.2 Circulatory-System-Based Disease Profiling
309(3)
12.3 Methods to Monitor Blood Flow
312(6)
12.4 Therapeutic Approaches Utilizing Manipulation of Blood Flow
318(2)
12.5 Lymph Node Mapping
320(2)
12.6 Lymphatic Drug Delivery
322(1)
Highlights of the
Chapter
322(4)
Exercises
326(1)
References
327(4)
13 Nanotechnology For Cancer
331(40)
13.1 Benefits of Cancer Nanotechnology
332(3)
13.2 Chemotherapy
335(4)
13.3 Cancer Gene Therapy
339(1)
13.4 Photodynamic Therapy
340(9)
13.5 Magnetic Therapy
349(4)
13.6 Photothermal Therapy
353(4)
13.7 Neutron Capture Therapy
357(2)
13.8 Circulating Tumor Cells
359(1)
13.9 NCI Alliance for Cancer Nanotechnology
360(1)
Highlights of the
Chapter
360(2)
Exercises
362(2)
References
364(7)
14 Gene Therapy
371(22)
14.1 The Principles, Steps, and Impact of Gene Therapy
372(2)
14.2 Methods of Gene Delivery
374(7)
14.3 Gene Augmentation Therapy
381(1)
14.4 Gene Silencing Therapy
381(3)
14.5 Indirect Gene Therapy Modulating Innate Immune Response
384(1)
14.6 Transmucosal Gene Delivery
385(1)
Highlights of the
Chapter
386(2)
Exercises
388(2)
References
390(3)
15 Nanotechnology For Infectious Diseases
393(40)
15.1 Pathogen Infections and Nanoparticle-Based Approaches
394(7)
15.2 HIV
401(7)
15.2.1 Diagnosis
402(2)
15.2.2 Vaccines and Antimicrobial Drugs
404(1)
15.2.3 Therapy
405(3)
15.3 Influenza
408(2)
15.3.1 Diagnosis
408(1)
15.3.2 Vaccines
409(1)
15.3.3 Therapy
409(1)
15.4 Tuberculosis
410(6)
15.4.1 Diagnosis
410(2)
15.4.2 TB Vaccine
412(1)
15.4.3 Therapy
412(4)
15.5 Malaria
416(6)
15.5.1 Vaccines
418(2)
15.5.2 Therapy
420(2)
Highlights of the
Chapter
422(2)
Exercises
424(2)
References
426(7)
16 Rejuvenation Therapy
433(14)
16.1 Rejuvenation Therapy: Fantasy or Reality?
433(3)
16.2 Free Radical Scavenging
436(3)
16.3 Chelation Therapy
439(2)
16.4 Hormone Therapy
441(1)
Highlights of the
Chapter
442(1)
Exercises
443(1)
References
444(3)
17 Stem Cell Biotechnology
447(14)
17.1 Stem Cell Biotechnology: Overview
448(1)
17.2 Cell Reprogramming
449(3)
17.3 Gene Transfection
452(1)
17.4 Somatic Cell Transdifferentiation
453(1)
17.5 Stem Cell Sorting
454(1)
17.6 Stem Cell Tracking
454(2)
Highlights of the
Chapter
456(1)
Exercises
456(1)
References
457(4)
18 Tissue Engineering
461(26)
18.1 Tissue Engineering: Overview
462(2)
18.2 Tissue Regeneration
464(3)
18.3 Nanotechnology in Tissue Engineering
467(5)
18.4 Nanofibers for Tissue Engineering
472(1)
18.5 Nanoparticle Delivery of Biomolecules
473(1)
18.6 Magnetically Assisted Tissue Engineering
474(1)
18.7 Tissue/Organ Printing
475(2)
18.8 Tissue Bonding
477(2)
Highlights of the
Chapter
479(3)
Exercises
482(2)
References
484(3)
19 Nanodermatology And Nanocosmetics
487(16)
19.1 Delivery Through Skin
487(1)
19.2 Skin Care and Nanotechnology
488(3)
19.3 Various Nanoparticles for Dermatology and Cosmetics
491(1)
19.4 Nanodermatology
492(2)
19.5 Nanocosmetics
494(3)
19.6 Nanotoxicology of the Skin
497(1)
Highlights of the
Chapter
497(1)
Exercises
498(1)
References
499(4)
20 Nanodentistry
503(26)
20.1 Nanotechnology for Dental Care
504(3)
20.2 Nanoparticles for Preventive Dentistry
507(2)
20.3 Nanomaterials for Restorative Dentistry
509(7)
20.4 Regenerative Dentistry
516(3)
20.5 Nanoparticle-Enhanced Dental Imaging and Oral Diagnostics
519(3)
20.6 Nanorobotics for Dentistry
522(1)
Highlights of the
Chapter
522(2)
Exercises
524(1)
References
525(4)
21 Nanotoxicity
529(26)
21.1 Toxicity of Nanoparticles
529(4)
21.2 Cytotoxicity
533(2)
21.3 In Vitro Cytotoxicity Assays
535(4)
21.4 In Vivo Toxicity
539(3)
21.5 In Vivo Toxicity Evaluation
542(1)
21.6 Nanotoxicity Studies on Selected Nanoparticles
542(5)
Highlights of the
Chapter
547(3)
Exercises
550(1)
References
551(4)
Index 555
PARAS N. PRASAD, PHD, is the SUNY Distinguished Professor of Chemistry, Physics, Electrical Engineering, and Medicine; the Samuel P. Capen Chair of Chemistry; and the Executive Director of the Institute for Lasers, Photonics, and Biophotonics at the University at Buffalo. He was named among the top 50 science and technology leaders in the world by Scientific American in 2005. He has published 700 scientific and technical papers in high-impact journals, three monographs that practically defined the fields of organic nonlinear optics, biophotonics, and nanophotonics, eight edited books, and holds numerous patents. He is the recipient of many scientific awards and honors (Morley Medal; Schoellkopf Medal; Guggenheim Fellowship; Sloan Fellowship; Western New York Health Care Industries Technology/Discovery Award; Fellow of the APS, OSA, and SPIE). He is a pioneer in nanomedicine and nanobioengineering, and has been giving plenary, opening, and keynote lectures worldwide in this field.